Seaweed Prevents Breast Cancer?

Funahashi, Hiroomi; Imai, Tsuneo; Mase, T.; Sekiya, Masanori; Yokoi, Kakeru; Hayashi, Hiromichi; Shibata, Arihiro; Hayashi, Takako; Nishikawa, Masaya; Suda, Namiko; Hibi, Yatsuka; Mizuno, Yutaka; Tsukamura, Kyosuke; Hayakawa, Akihiro; Tanuma, Sei–ichi

doi:10.1111/j.1349-7006.2001.tb01119.x

Cited by 130 publications

(92 citation statements)

References 15 publications

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“…Furthermore, there are several reports regarding the preventive effect of seaweed consumption against breast cancer (Teas, 1983;Kang et al, 2004). However, it is important to recognize that to increase seaweed intake beyond current levels in Japan does not necessarily mean enhanced health benefits; indeed some researchers have shown disadvantages, for example, stimulatory effects upon cancers (Ashi et al, 1978;Watanabe et al, 1978;Reddy et al, 1985;Funahashi et al, 2001). Fiber intake pattern S Fukuda et al…”

Section: Fiber Intake Pattern S Fukuda Et Almentioning

confidence: 99%

Pattern of dietary fiber intake among the Japanese general population

et al. 2006

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Objectives: To evaluate the dietary fiber (DF) intake pattern among the Japanese general population. Design: We performed a dietary survey among the general population in northern Japan to evaluate the intake patterns. DF intake was calculated by substituting the DF content of each food in the Dietary Fiber Table for the intake of each food from this dietary survey. Subjects: Five hundred and seventy-seven subjects participated in the study, 198 men and 379 women. Results: In subjects with higher DF intakes the origins of the DF that were from all food groups, but with the notable exception of rice. The contribution of the seaweed group was of particular interest. From multiple regression analysis, as for food group, seaweeds showed the highest positive correlation with DF intake in both genders, followed by vegetables, pulses, fruits. On the other hand, rice showed the negative correlation with DF intake in both genders. As for life factor, body mass index showed the negative correlation with DF intake in women. Conclusion: Seaweed, a typical Japanese food, was most related to the increase in DF intake for the Japanese general population, whereas rice, the Japanese staple, had a small influence on decreased DF intake.

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Section: Fiber Intake Pattern S Fukuda Et Almentioning

confidence: 99%

Pattern of dietary fiber intake among the Japanese general population

et al. 2006

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“…The putative protective effect of seaweed on breast cancer is in accord with the relatively low breast cancer rates in Japan (19) , where seaweed-rich diets are consumed and with the increasing breast cancer rates in Japanese women who emigrate (20) or consume a Western style diet (21) . Animal studies (10,22,23) and in vitro studies (23 -25) demonstrated the anticarcinogenic effects of seaweeds against mammary carcinogenesis. Iodine as well as other components of seaweeds have been suggested to act as antioxidants (26) and induce apoptosis in human breast cancer cell lines (23) .…”

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confidence: 99%

“…Animal studies (10,22,23) and in vitro studies (23 -25) demonstrated the anticarcinogenic effects of seaweeds against mammary carcinogenesis. Iodine as well as other components of seaweeds have been suggested to act as antioxidants (26) and induce apoptosis in human breast cancer cell lines (23) . In an ecological study, the regions where iodine intake was low had higher breast cancer mortality rates (27) .…”

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confidence: 99%

A case–control study on seaweed consumption and the risk of breast cancer

et al. 2009

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Gim (Porphyra sp.) and miyeok (Undaria pinnatifida) are the seaweeds most consumed by Koreans. We investigated the association between the intake of gim and miyeok and the risk of breast cancer in a case -control study. Cases were 362 women aged 30 -65 years old, who were histologically confirmed to have breast cancer. Controls visiting the same hospital were matched to cases according to their age (SD 2 years) and menopausal status. Food intake was estimated by the quantitative FFQ with 121 items, including gim and miyeok. Conditional logistic regression analysis was used to obtain the OR and corresponding 95 % CI. The average intake and consumption frequency of gim in cases were lower than in controls. The daily intake of gim was inversely associated with the risk of breast cancer (5th v. 1st quintile, OR, 0·48; 95 % CI, 0·27, 0·86; P for trend, 0·026) after adjustment for potential confounders. After stratification analysis was performed according to menopausal status, premenopausal women (5th v. 1st quintile, OR, 0·44; 95 % CI, 0·24, 0·80; P for trend, 0·007) and postmenopausal women (5th v. 1st quintile, OR, 0·32; 95 % CI, 0·13, 0·80; P for trend, 0·06) showed similar inverse associations between gim intake and the risk of breast cancer after an adjustment for potential confounders except dietary factors. Miyeok consumption did not have any significant associations with breast cancer. These results suggest that high intake of gim may decrease the risk of breast cancer.

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“…Funahashi et al reported recently that both Japanese edible Wakame seaweed and also a direct uptake of inorganic iodine [26] by tumor have experimentally a suppressive effect on DMBA-induced breast tumors growth in the rat. NIS expression is inversely related to undifferentiation, malignity and it is directly related to likelihood of therapeutic effectiveness of radioiodine therapy.…”

Section: Iodine and Thyroid Hormone In The Therapy Of Breast Diseasesmentioning

confidence: 99%

Iodine Deficieency and Its Proliferation in Cancer Increase

Emmanuel¹,

Oliver²,

Angela³

2016

AJLSR

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Iodine is an essential element in human physiology. It's well known to play vital role in thyroid functions. However it has been updated to be the most important element with the highest percentage of demand by the human body. This is because iodine is the heaviest and richest in electrons among required elements in the animal diet. Inorganic iodides are necessary for all living vegetable and animal cells, but only the vertebrates have the thyroid gland and its iodinated hormones. In humans, the total amount of iodine is about 30-50 mg and less than 30% is present in thyroid gland and its hormones. About 60-80% of total iodine is non-hormonal as contained in its extrathyroidal tissues. Dietary iodine deficiency is associated with the development of mammary pathology and cancer. Mammary gland embryogenetically derived from primitive iodide-concentrating ectoderma, and alveolar and ductular cells of the breast specialize in uptake and secretion of iodine in milk in order to supply offsrings with this important trace-element. Breast and thyroid share an important iodide-concentrating ability and an efficient peroxidase activity, which transfers electrons from iodides to the oxygen of hydrogen peroxide, forming iodoproteins and iodolipids, and so protect the cells from peroxidative damage. Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid nodules and differentiated thyroid cancer.

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Seaweed Prevents Breast Cancer?

Cited by 130 publications

References 15 publications

Pattern of dietary fiber intake among the Japanese general population

Pattern of dietary fiber intake among the Japanese general population

A case–control study on seaweed consumption and the risk of breast cancer

Iodine Deficieency and Its Proliferation in Cancer Increase

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