Climate change-induced alterations in temperature variation, ozone
exposure, water salinity and acidification, and hypoxia might influence
immunity in diverse animal groups from fish to mammals. Pyroptosis is a
type of lytic pro-inflammatory programmed cell death, which participates
in the innate immune response, and is involved in multiple diseases
characterized by inflammation and cell death, mostly studied in human
cells. Here, I review previous research pointing to the potential impact
of climate change on pyroptotic cell death in different animal cells. I
propose that temperature-, ozone exposure-, salinity-, acidification-
and hypoxia-induced pyroptotic cell death should be better understood to
be able to mitigate the adverse effects of climate change on animal
physiology. This is of high importance considering the increasing
frequency of climate-based changes in these environmental parameters,
and the critical function of pyroptosis in immune responses of animals.