Seasons but not ethnicity influence urinary iodine concentrations in Belgian adults

Moreno‐Reyes, Rodrigo; Carpentier, Yvon; Macours, Pascale; Gulbis, Béatrice; Corvilain, Bernard; Glinoer, Daniel; Goldman, Serge

doi:10.1007/s00394-010-0137-4

Cited by 34 publications

(27 citation statements)

References 27 publications

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“…Median fasting morning urinary iodine levels in our cohort are in agreement with acknowledged mild iodine deficiency in Belgium (53,54). Uncorrected urinary iodine levels were not associated to thyroid parameters in this cohort, in line with a previous large study (NHANES III) (35).…”

Section: Pz009supporting

confidence: 92%

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Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men

Roef¹,

Taes

Toye

et al. 2013

European Journal of Endocrinology

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Objective: Variation in thyroid hormone (TH) concentrations between subjects is greater than in a single subject over a prolonged period of time, suggesting an individual set point for thyroid function. We have previously shown that TH levels within normal range are associated with clinical indices such as bone mass, BMI, and heart rate. The aim of this study on young men was therefore to gain insight into the determinants of variation in TH levels among healthy subjects. Methods: Healthy male siblings (nZ941, 25-45 years) were recruited in a cross-sectional, populationbased study; a history or treatment of thyroid disease and thyroid auto-immunity were exclusion criteria. A complete assessment of TH status was performed (TSH, free thyroxine (FT 4 ), free triiodothyronine (FT 3 ), thyroperoxidase, and thyroglobulin antibodies, reverse T 3 (rT 3 ), thyroidbinding globulin (TBG), and urinary iodine levels). Genotyping was performed by TaqMan and KASP (KBiosciences) genotyping assays. Results: (F)T 4 , rT 3 , and TBG had heritability estimates between 80 and 90%. Estimates were lower for (F)T 3 (60%) and lowest for TSH (49%). Significant associations were observed between different single-nucleotide polymorphisms (SNPs) in the thyroid pathway and TSH, FT 4 , ratio FT 3 :FT 4 , and rT 3 . Nevertheless, these SNPs only explain a limited part of the heredity. As to age and lifestyle-related factors, (F)T 3 was negatively related to age and education level, positively to smoking and BMI (all P!0.0001) but not substantially to urinary iodine concentrations. Smoking was also negatively related to TSH and positively to FT 4 . Conclusion: Both genetic and lifestyle-related factors play a role in determining between-subject variation in TH levels in euthyroid young men, although genetic factors seem most important.

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Section: Pz009supporting

confidence: 92%

“…Iodine intake is related to the consumption of dairy products in our population, in agreement with a previous study suggesting that milk is the main source of iodine in Belgium (54). However, we do not observe seasonal variation in urinary iodine or TH levels, in contrast with a recent study of Moreno-Reyes et al (53).…”

Section: Pz009supporting

confidence: 91%

Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men

Roef¹,

Taes

Toye

et al. 2013

European Journal of Endocrinology

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“…The UIC was found to be at the lower end of the normal range (107.3 µg/g) (Konrade et al, 2014), which can be considered an improvement compared with results of the previous nationwide cross-sectional school study (Selga et al, 2000). Similar to the results of other studies conducted in mild iodinedeficient regions of Europe (Als et al, 2003;Moreno-Reyes et al, 2011;Arrizabalaga et al, 2012), we found seasonal UIC fluctuations. In autumn, the UIC was at the lower end of the normal range (129.7 µg/g Cr), but it was significantly lower during the spring sampling (78.3 µg/g Cr) (Konrade et al, 2014).…”

Section: Iodine Status In Childrensupporting

confidence: 91%

Iodine Deficiency in Latvia: Current Status and Need for National Recommendations

Konrāde

Kalere

Strēle

et al. 2017

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…This heterogeneity may instead reflect the heterogeneity of cellular density from one nodule to another due to various decreases in colloid space, the difficulty of estimating the actual weight of the active nodule (19) or the presence of an impaired iodide organification as observed in 60% of AFTNs (20). Similar to several other countries, Belgium is an area with mild iodine deficiency (21,22), and the goitrogenic role of pregnancy is observed only in iodine-deficient areas (23). Therefore, we cannot claim that our observation is valid for patients from areas with optimal iodine intake.…”

Section: Discussionmentioning

confidence: 99%

TSH measurement is not an appropriate screening test for autonomous functioning thyroid nodules: a retrospective study of 368 patients

Chami

Moreno‐Reyes

Corvilain

2014

European Journal of Endocrinology

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Objective: Based on the assumption that normal TSH concentration rules out the presence of autonomous functioning thyroid nodules (AFTNs), clinical guidelines on the management of thyroid nodules only recommend a thyroid scan if TSH concentration is subnormal. However, the proportion of AFTN presenting with a normal TSH is unknown. Our objective is therefore to determine the proportion of AFTNs with a normal TSH level to ascertain whether a normal TSH really rules out an AFTN. Design: Retrospective study on 368 patients with an AFTN. Methods: Thyroid scans with a diagnosis of AFTN were reviewed retrospectively by one of us (R Moreno-Reyes), blinded to the clinical data. The diagnosis of solitary AFTN was confirmed in 368 patients. Among them, we selected 217 patients based on the absence of another thyroid nodule O10 mm, the absence of medical conditions able to interfere with thyroid function, and the completeness of the data. Results: The proportion of AFTNs with normal TSH was 49%. This proportion increased to 71% in patients for whom thyroid scan was performed in the workup of a thyroid nodule. Conclusions: Our data suggest that serum TSH is not an effective screening tool to diagnose AFTNs. Using 'TSH-only' screening, as recommended by the majority of guidelines, the diagnosis of AFTN would have been missed in 71% of our patients in the workup of a thyroid nodule. Thyroid scan remains the gold standard for detecting AFTN and should be considered before performing fine-needle aspiration cytology (FNAC), as the reliability of FNAC in an unsuspected AFTN remains unclear.

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Seasons but not ethnicity influence urinary iodine concentrations in Belgian adults

Abstract: Seasonal fluctuations in UIC suggest that the risk of iodine deficiency among adults living in Brussels is higher in fall-winter than in spring-summer. The prevalence of MID in Brussels is high among adults but ethnicity does not appear to influence iodine status.

Cited by 34 publications

References 27 publications

Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men

Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men

Iodine Deficiency in Latvia: Current Status and Need for National Recommendations

TSH measurement is not an appropriate screening test for autonomous functioning thyroid nodules: a retrospective study of 368 patients

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