Seasonality of disease in Kuwait

Douglas, A. S.; Rawles, John; Al‐Sayer, H.; Allan, T.M.

doi:10.1016/0140-6736(91)93069-l

Cited by 91 publications

(50 citation statements)

References 8 publications

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“…Climatic factors have also been observed to influence coronary artery disease. [46][47][48] During the winter, sudden cardiac death is increased compared with the summer months, as shown in a recent population-based study (Figure 10). …”

Section: Other Possible Triggersmentioning

confidence: 83%

“…[31][32][33] Two approaches appear to be possible in overcoming the limitation of obtaining first hand historical data on the event preceding sudden cardiac death. 34 First, patients successfully resuscitated from sudden cardiac death may be interviewed in order to evaluate possible triggering events of the disease similar to the method used on studies on the Vascular Medicine 1999; 4: [41][42][43][44][45][46][47][48][49] triggering of non-fatal myocardial infarction. To include a sufficient number of subjects in such studies, it is necessary to monitor the rescue services in a large area.…”

Section: Physical Exertionmentioning

confidence: 99%

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Circadian variation and triggering of cardiovascular events

Willich

1999

Vasc Med

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Myocardial infarction and sudden cardiac death demonstrate a marked circadian variation with an increased risk during the morning after awakening and arising. The recognition of the morning increase of acute cardiovascular events has convinced many that they may be triggered by morning activities. It is of note, however, that cardiovascular events occur throughout the day -even if at lower frequency compared with the morning.There is a strong association between external triggers and the onset of myocardial infarction and sudden cardiac death beyond what is to be expected by chance alone. The magnitude of this association (relative risk two-to threefold) is comparable with the known long-term risk factors of cardiac disease. Trigger factors occur relatively frequently and may play a causative role in up to 20% of cases of acute coronary syndromes. Physical exertion, bursts of anger and sexual activity have been proved to have triggering potential. Other possible triggers include external and environmental events such as earthquakes, war threat and climatic factors.The pathophysiological links between external triggers and the onset of cardiovascular events are important in addressing the question of a causal relationship between triggers and disease onset and in perhaps improving preventive strategies.

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Section: Other Possible Triggersmentioning

confidence: 83%

Section: Physical Exertionmentioning

confidence: 99%

Circadian variation and triggering of cardiovascular events

Willich

1999

Vasc Med

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“…In these lines, most of reports, but not all, have demonstrated a significant winter increase in cardiovascular abnormalities and cardiac death, especially in the northern hemisphere, where there are winter temperature extremes 14,15 . Quite interesting, sudden cardiac death have been also reported in regions with most comfortable winter 16,17 , 2) During the winter, increases in haemoconcentration (erythrocyte count, plasma cholesterol and plasma fibrinogen levels) have been reported, which could contribute to arterial thrombosis 18 . In this way, rapid coronary deaths could result from rupture of atheromatous plaques during hypertension and cold-induced coronary spasm 19,20 .…”

Section: Discussionmentioning

confidence: 99%

Is cold the new hot in sudden unexpected death in epilepsy? Effect of low temperature on heart rate of rats with epilepsy

Sonoda

Colugnati

Scorza

et al. 2008

Arq. Neuro-Psiquiatr.

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-Sudden unexpected death in epilepsy (SUDEP) is the commonest cause of seizure-related mortality in people with refractory epilepsy. Several risk factors for SUDEP are described; however, the importance of including low temperatures as risk factor for SUDEP was never explored. Based on this, the aim of this study was to evaluate the heart rate of rats with epilepsy during low temperature exposure. Our results showed that low temperature clearly increased the heart rate of rats with epilepsy. Taken together, we concluded that exposure to low temperatures could be considered important risk factors from cardiovascular abnormalities and hence sudden cardiac death in epilepsy.KEy wOrDS: epilepsy, seizure, SUDEP, low temperatures, heart. É o frio responsável por mortes inesperadas em epilepsia ? Efeito de temperaturas baixas na frequência cardíaca de ratos com epilepsia.Resumo -A morte súbita e inesperada nas epilepsias (SUDEP) é considerada a maior causa de morte em indivíduos com epilepsia refratária. Vários fatores de risco para SUDEP têm sido descritos, no entanto, a inclusão das baixas temperaturas como um possível fator de risco para SUDEP não foi verificada até o momento. Nesse sentido, o objetivo desse estudo foi verificar a freqüência cardíaca de animais com epilepsia expostos as temperaturas baixas. Nossos resultados demonstraram que as baixas temperaturas são capazes de aumentar significativamente a freqüência cardíaca de animais com epilepsia. Dessa forma, concluímos que as baixas temperaturas podem ser consideradas um importante fator de risco de possíveis alterações cardiovasculares e até mesmo morte súbita cardíaca nas epilepsias.PAlAVrAS-chAVE: epilepsia, crises epilépticas, SUDEP, baixas temperaturas, coração. The epilepsies are the most common serious neurological condition. In developed countries, the incidence of epilepsy is around 50 per 100 000 people per year, and is higher in infants and elderly people 1,2 . The most commonly reported etiological factors are tumors, head injuries, stroke, genetic inheritance and infections of the central nervous system 1,3 . In resource-poor countries, endemic infections, such as neurocysticercosis and malaria seem to be major risk factors 1 . Moreover, people with epilepsy are two-to three-fold increase to die prematurely than those without epilepsy and the most common epilepsyrelated category of death is sudden unexpected death in epilepsy (SUDEP).SUDEP is defined as sudden, unexpected, witnessed or unwitnessed, nontraumatic and nondrowning deaths in patients with epilepsy, with or without evidence of a seizure and excluding documented status epilepticus (SE), in which post mortem examination does not reveal a toxicological or anatomical cause of death 4 . Information concerning risk factors for SUDEP is conflicting, but potential risk factors include: age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure frequency, seizure type and antiepileptic drugs number 5 . The exact pathophysiological causes of SUDEP are unknown, b...

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“…3 More patients sustain infarcts on colder days in winter or summer, 21 and in Kuwait the same pattern of cardiovascular death was seen as in Scotland, suggesting that it is the relative, not the absolute temperature change which is important. 22 …”

Section: Winter (Circannual Variation)mentioning

confidence: 99%

New insights into the mechanisms of temporal variation in the incidence of acute coronary syndromes

Strike

Steptoe

2003

Clinical Cardiology

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Summary:Over the last few years, patterns have emerged regarding the daily (circadian), weekly (circaseptan), and yearly (circannual) variation in the incidence of acute coronary syndromes (ACS). Peaks of incidence occur in the morning, on Mondays, and in winter. There is a difference in the pattern of incidence in different subgroups such as diabetics and smokers, which, along with the incidence alteration seen with aspirin and beta blockers, gives us some potential understanding of underlying mechanisms. Recent advances in the study of endothelial function, cytokine biology, and adhesion molecules have led to new insights into the way that natural fluctuations in these systems may affect ACS incidence. It is hoped that understanding these developments will lead to therapeutic advances in ACS prevention.

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Seasonality of disease in Kuwait

Cited by 91 publications

References 8 publications

Circadian variation and triggering of cardiovascular events

Circadian variation and triggering of cardiovascular events

Is cold the new hot in sudden unexpected death in epilepsy? Effect of low temperature on heart rate of rats with epilepsy

New insights into the mechanisms of temporal variation in the incidence of acute coronary syndromes

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