Seasonality of clinical isolation of rapidly growing mycobacteria

Han, Xiang-Yang

doi:10.1017/s095026880700982x

Cited by 12 publications

(11 citation statements)

References 12 publications

(19 reference statements)

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“…Rainfall is a reported risk factor for legionellosis (31,32). We previously noted that the clinical recovery of rapidly growing mycobacteria, also of an environmental origin, followed the seasonal rise and fall of rainfall in Houston (33). Thus, future studies of Legionella species in the Houston area environment may be revealing.…”

Section: Discussionmentioning

confidence: 92%

Microbiological and Clinical Studies of Legionellosis in 33 Patients with Cancer

et al. 2015

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Section: Discussionmentioning

confidence: 92%

Microbiological and Clinical Studies of Legionellosis in 33 Patients with Cancer

et al. 2015

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“…It is noteworthy that human NTM illness is more frequently reported during the summer and autumn seasons [36]. …”

Section: Discussionmentioning

confidence: 99%

Occurrence of potentially pathogenic nontuberculous mycobacteria in Mexican household potable water: a pilot study

et al. 2013

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BackgroundNontuberculous mycobacteria (NTM) are environmental opportunistic pathogens found in natural and human-engineered waters, including drinking water distribution systems and household plumbing. This pilot study examined the frequency of occurrence of NTM in household potable water samples in Mexico City. Potable water samples were collected from the “main house faucet” and kitchen faucet. The presence of aerobic-mesophilic bacteria (AMB), total coliforms (TC), fecal coliforms (FC) and NTM species were determined. Mycobacteria species were identified by PCR restriction enzyme pattern analysis (PRA) of the 65-kDa heat shock protein gene (hsp65) and sequencing of the hypervariable region 2 (V2) of the 16S rRNA gene and of the rpoB gene.ResultsAMB (<100 CFU/ml) were present in 118 out of 120 samples; only two samples were outside guidelines ranges (>100 CFU/ml). TC and FC were detected in four and one samples, respectively. NTM species were recovered from 16% samples (19/120) and included M. mucogenicum (nine), M. porcinum (three), M. avium (three), M. gordonae (one), M. cosmeticum (one), M. fortuitum (one), and Mycobacterium sp (one). All household water samples that contained NTM complied with the standards required to grade the water as “good quality” potable water.ConclusionHousehold potable water may be a potential source of NTM infection in Mexico City.

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“…16,17 Within the United States, human infections (and outbreaks) due to RGM have been reported more frequently in southern coastal states (Florida to Texas). 13,18 Whether this truly represents a difference in disease prevalence or rather reflects other factors, such as heightened awareness or reporting bias, is not yet clear due to the aforementioned difficulty in determining exact prevalence. A recent study conducted at a large cancer center in Texas, an area considered endemic for RGM, noted seasonal fluctuations in the number of RGM isolated, corresponding to periods of increased temperature and following heavy rainfall, suggesting that those climatic conditions affect RGM activity and may possibly factor into infection risk.…”

Section: Epidemiologymentioning

confidence: 99%

“…A recent study conducted at a large cancer center in Texas, an area considered endemic for RGM, noted seasonal fluctuations in the number of RGM isolated, corresponding to periods of increased temperature and following heavy rainfall, suggesting that those climatic conditions affect RGM activity and may possibly factor into infection risk. 18 Infection can occur in both immunocompetent and immunocompromised hosts. The spectrum of disease caused by RGM is large, ranging from localized cutaneous to pulmonary to disseminated infection.…”

Section: Epidemiologymentioning

confidence: 99%

Diagnosis and Treatment of Infections Caused by Rapidly Growing Mycobacteria

Colombo

Olivier

2008

Semin Respir Crit Care Med

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Rapidly growing mycobacteria (RGM) are ubiquitous environmental organisms capable of causing a wide variety of infections in humans. The prevalence of RGM infections appears to be increasing, although exact incidence rates are unknown. Although some risk factors for pulmonary RGM infection have been determined, the specific host factors predisposing to disease in the majority of cases are not clear. Significant advances in molecular methods of mycobacterial identification have led to isolation of more varieties, changes in taxonomy, and more rapid and accurate diagnosis of RGM from clinical isolates. Despite significant advances in the field, diagnosing and treating RGM pulmonary infections remain complicated. Current guidelines are based on the most commonly encountered NTM. Their applicability to less frequent RGM isolates has not been definitively established. Treatment often requires multiple antimicrobial agents for prolonged periods of time, with varying degrees of success and significant associated morbidity.

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Seasonality of clinical isolation of rapidly growing mycobacteria

Cited by 12 publications

References 12 publications

Microbiological and Clinical Studies of Legionellosis in 33 Patients with Cancer

Microbiological and Clinical Studies of Legionellosis in 33 Patients with Cancer

Occurrence of potentially pathogenic nontuberculous mycobacteria in Mexican household potable water: a pilot study

Diagnosis and Treatment of Infections Caused by Rapidly Growing Mycobacteria

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