Seasonality in bipolar disorder: Effect of sex and age

Fellinger, Matthäus; Waldhoer, Thomas; König, Daniel; Hinterbuchinger, Barbara; Pruckner, Nathalie; Baumgärtner, Josef; Vyssoki, Sandra; Vyssoki, Benjamin

doi:10.1016/j.jad.2018.09.073

Cited by 24 publications

(24 citation statements)

References 29 publications

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“…The later the survey participants fell asleep on school days and the later the sun rose, the more likely they were to demonstrate depressive symptoms and FA. Mood seasonality has repeatedly been noted in previous studies, with the highest frequency of depression in winter (Fellinger et al, ; Geoffroy et al, , ; Lee et al, ). A latitudinal gradient of mood seasonality, with maximum values of the incidence of depression at high latitudes has also been reported (Borisenkov et al, ; Friedman, Even, et al, ; Friedman, Gyulai, et al, ; Magnusson, ).…”

Section: Discussionsupporting

confidence: 61%

“…Previous data have shown the circadian system dysfunction and sleep disorders in persons with depression (Alloy et al, ; Borisenkov et al, ; Levandovski et al, ). Seasonal variation in the severity and frequency of depression (Fellinger et al, ; Geoffroy et al, ; Geoffroy, Bellivier, Scott, & Etain, ; Lee, Tsai, & Lin, ), as well as the prevalence of depression among residents of high latitudes (Borisenkov et al, ; Friedman et al, ; Friedman, Even, Thuile, Rouillon, & Guelfi, ; Magnusson, ) may be explained by the association between circadian system misalignment and depression. It is known that the photoperiod is the main external synchronizing signal for the circadian system (Aschoff, ).…”

Section: Introductionmentioning

confidence: 99%

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Food addiction and symptoms of depression among inhabitants of the European North of Russia: Associations with sleep characteristics and photoperiod

Borisenkov

Popov

Tserne

et al. 2020

Euro Eating Disorders Rev

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The purpose of this investigation was to study the sleep-wake rhythm characteristics of young persons with food addiction (FA) and symptoms of depression. A total of 2,360 young persons living in northern European Russia were included in the study.The average age of the respondents (± standard deviation [SD]) was 17.9 [4.6] years (66.6% female). Each participant provided personal data and filled in three questionnaires: the Munich Chronotype Questionnaire, the Zung Self-Rating Depression Scale, and the Yale Food Addiction Scale. FA was detected in 8.9% of respondents, and moderate-to-severe symptoms of depression were detected in 16.7% of respondents. FA and depressive symptoms were more often detected in females. Age and body mass index were shown to be significantly associated with FA. There were positive associations between the time of sunrise and FA and depressive symptoms. Persons who had symptoms of depression also tended to have a later chronotype, lower sleep efficiency, later sleep onset, higher sleep inertia, and greater sleep latency on school days. A positive relationship between FA and the time of sleep onset on school days was also revealed. Thus, the results indicate that prolonged wakefulness in the evening after sunset was associated with FA.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Food addiction and symptoms of depression among inhabitants of the European North of Russia: Associations with sleep characteristics and photoperiod

Borisenkov

Popov

Tserne

et al. 2020

Euro Eating Disorders Rev

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“…Separate multiple regression analyses were performed for each PRS, considered the main independent variable while controlling for sex, age, diagnostic category based on mood polarity (MDD vs. BD) and chronotype. Because of the previously described existence of external factors influencing seasonality, 19‐21 an interaction analysis was performed exploring the interaction between each PRS and all covariates (sex, age, diagnostic category and chronotype). For presentation purposes, we divided patients according to age into three groups (<40 years, 40–60 years, >60 years) to differentiate between young, middle‐aged and older adults.…”

Section: Methodsmentioning

confidence: 99%

“…This variability might be because of differences in the seasonal pattern depending on the subtype of BD as data suggest higher rates of seasonality in patients with type II BD, 19 as well as the existence of several influencing factors. For example, studies have shown that in patients with BD, the presence of a seasonal pattern is modulated by sex and age, with results suggesting higher rates of seasonality in individuals of younger ages, while gender differences are more inconsistent 20,21 . It must be noted that there are two separate components of seasonality.…”

Section: Introductionmentioning

confidence: 99%

Clock gene polygenic risk score and seasonality in major depressive disorder and bipolar disorder

Ferrer¹,

Costas

Gratacòs

et al. 2020

Genes Brain and Behavior

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Seasonal changes in mood and diurnal preference are two well‐characterized chronobiological phenotypes in major depressive disorder (MDD) and bipolar disorder (BD). The biological mechanisms regulating physiological changes related to seasonality and chronotype involve several genes known as “clock” or circadian genes. Our goal was to study the relationship between the polygenic risk score (PRS) obtained from a set of clock genes and chronobiological traits in patients with mood disorders. The sample included 445 patients with mood disorders (256 MDD; 189 BD). Seasonality was assessed using the Seasonal Pattern Assessment Questionnaire (SPAQ), and chronotype was assessed using the Horne and Östberg Morningness–Eveningness Questionnaire. We selected 248 single nucleotide polymorphisms located within 19 genes. PRS for both MDD and BD was calculated using the Psychiatric Genetics Consortium latest datasets as discovery samples. Another PRS was calculated using results from a genome‐wide association study focusing on chronotype. SPAQ results were significantly associated with MDD‐PRS (p = 0.037) and chronotype‐PRS (p = 0.019), which also showed a significant interaction with age (p = 0.039). No significant association was observed between the measured PRS and chronotype. Our results reflect that small effect variants associated with MDD and chronotype within clock genes are associated with seasonality traits in patients with mood disorders, further explaining the mechanism through which the circadian system might influence mood disorder clinical presentation. Future studies measuring PRS from specific gene sets and focusing on biological endophenotypes will help to elucidate the pathways from genetic variations to clinical outcome.

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“…Notably, NMDA-R encephalitis, an autoimmune disease in which autoimmune antibodies attack NMDA receptors at central neuronal synapses, is one of the diseases showing most prominent degrees of sex bias, and predominantly seen in young females (30,31). It is well known that several sex differences also exist in the presentation and clinical course of BD; and females with BD are more prone to develop depressive and mixed episodes, BD type II, seasonal variations and rapid cycling BD (44)(45)(46)(47)(48), as well as comorbid obesity (49), autoimmune thyroid diseases (50)(51)(52)(53) and migraine (54,55). Recent evidence show several sex specific differences in several parameters, including oxidative stress (56), cognition (57,58) and brain structures between sexes in BD (59,60).…”

Section: Introductionmentioning

confidence: 99%

Increased serum levels of NMDA receptor antibodies in female patients with bipolar disorder

Ceylan¹,

Akan²,

Doyuran³

et al. 2018

J Clin Psy

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Objective: Glutamatergic/GABAergic imbalance due to autoimmune antibodies targeting N-methyl-D-aspartate receptors (NMDA-R) is considered to be one of the shared pathways between bipolar disorder (BD) and autoimmune diseases. Evidence shows female vulnerability to autoimmune disorders, and suggests a sex-specific approach in autoimmunity research in BD. We aimed to assess serum concentrations of NMDA-R antibodies and density of NMDA and GABA receptors on platelets in euthymic patients with BD in comparison to healthy individuals; and to determine the impact of sex on serum concentrations of NMDA-R antibodies and the density of NMDA and GABA receptors on platelets. Method: NMDA antibody IgG were detected in serum samples of 27 DSM IV euthymic patients with bipolar disorder (16 females, 11 males) and 33 healthy individuals (17 females, 16 males), using ELISA method. The densities of NMDA and GABA receptors on platelets were investigated using immunocytochemical methods. Results: Patients with BD presented higher serum levels of NMDA-R antibodies in comparison to healthy individuals (p<0.001). The densities of NMDA and GABA receptor on platelets were similar in both groups. The NMDA-R antibody levels were influenced by both diagnosis and sex (F=5.813, df=1, p =0.020). Tserum lithium levels showed a significant linear association with the serum NMDA-R antibody levels even adjusting for age, sex, body mass index (F=-56.26, t=-2.52, p = 0.015, CI: -101.12/-11.40). Discussion: Our findings support a potential role of NMDA-R antibodies in the underlying pathophysiology of BD, particularly for females.

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Seasonality in bipolar disorder: Effect of sex and age

Cited by 24 publications

References 29 publications

Food addiction and symptoms of depression among inhabitants of the European North of Russia: Associations with sleep characteristics and photoperiod

Food addiction and symptoms of depression among inhabitants of the European North of Russia: Associations with sleep characteristics and photoperiod

Clock gene polygenic risk score and seasonality in major depressive disorder and bipolar disorder

Increased serum levels of NMDA receptor antibodies in female patients with bipolar disorder

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