Seasonality Effects on Antibacterial and Antibiotic Potentiating Activity against Multidrug-Resistant Strains of Escherichia coli and Staphylococcus aureus and ATR-FTIR Spectra of Essential Oils from Vitex gardneriana Leaves

Pereira, Raimundo Luiz Silva; Freitas, Thiago Sampaio de; Freitas, Priscilla Ramos; Araújo, Ana Carolina Justino de; Campina, Fábia F.; Fidelis, Kleber Ribeiro; Vale, Jean Parcelli Costa do; Barreto, A. L. H.; Coutinho, Henrique Douglas Melo; Bandeira, Paulo Nogueira; Teixeira, Alexandre Magno Rodrigues; Santos, Hélcio Silva dos

doi:10.1007/s00284-020-02226-6

Cited by 2 publications

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“…However, they had little effects on fluoroquinolone antibiotics ofloxacin and ciprofloxacin ( Figs. S2E and S2F ), in contrast to earlier reports showing that ofloxacin was potentiated by ascorbic acid against Staphylococcus aureus ( Dey & Bishayi, 2018 ) and certain oils could reduce the MIC of ofloxacin against E. coli and S. aureus ( Pereira et al, 2020 ). In addition, we found that none of 5-methylindole, 2-methylindole and indole could potentiate tobramycin and other types of aminoglycosides against S. aureus cells in exponential-phase ( Figs.…”

Section: Resultscontrasting

confidence: 72%

5-Methylindole kills various bacterial pathogens and potentiates aminoglycoside against methicillin-resistant Staphylococcus aureus

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Sun²,

Fu³

et al. 2022

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Antibiotic resistance of bacterial pathogens has become a severe threat to human health. To counteract antibiotic resistance, it is of significance to discover new antibiotics and also improve the efficacy of existing antibiotics. Here we show that 5-methylindole, a derivative of the interspecies signaling molecule indole, is able to directly kill various Gram-positive pathogens (e.g., Staphylococcus aureus and Enterococcus faecalis) and also Gram-negative ones (e.g., Escherichia coli and Pseudomonas aeruginosa), with 2-methylindole being less potent. Particularly, 5-methylindole can kill methicillin-resistant S. aureus, multidrug-resistant Klebsiella pneumoniae, Mycobacterium tuberculosis, and antibiotic-tolerant S. aureus persisters. Furthermore, 5-methylindole significantly potentiates aminoglycoside antibiotics, but not fluoroquinolones, killing of S. aureus. In addition, 5-iodoindole also potentiates aminoglycosides. Our findings open a new avenue to develop indole derivatives like 5-methylindole as antibacterial agents or adjuvants of aminoglycoside.

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Section: Resultscontrasting

confidence: 72%