Seasonal variations of DNA synthesis in intestinal epithelial cells of hibernating animals—I. DNA synthesis in intestinal epithelial cells of ground squirrel (Citellus undulatus) during deep hibernation

Kruman, Inna I.; Kolaeva, S. G.; Iljasova, E.N.; Зубрихина, Г Н; Khachko, V.N.; Petrova, Andreana

doi:10.1016/0305-0491(86)90349-4

Cited by 11 publications

(7 citation statements)

References 8 publications

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“…Proliferation and/or replacement of cells are clearly energy-expensive biosynthetic processes, so it would make sense that these activities are suppressed to a minimum under conditions of severe oxygen restriction. Taking into account the findings presented in Chapter 2, along with reports by (Kruman et al 1986;Kolaeva et al, 1980). These results suggest that DNA synthesis is markedly reduced during the hibernation period.…”

Section: Introductionsupporting

confidence: 55%

Cell Cycle Regulation by Post-Translational and Post-Transcriptional Mechanisms in an Anaerobic Extremist- the Anoxia Tolerant Turtle, Trachemys Scripta Elegans

Biggar¹

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As a model for vertebrate long-term survival in oxygen restricted environments, the red-eared slider turtle (T. s. elegans) can adapt at the biochemical level to deal with hibernation occurring in oxygen-free (anoxic) cold water (<10°C). In this thesis I hypothesized that the mechanisms which suppress ATP-expensive cell cycle activity, would contribute to establishing an hypometabolic state. To explore this possibility, this thesis studied the post-transcriptional and post-translational mechanisms of cell cycle arrest during anoxic stress in the freshwater turtle.

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Section: Introductionsupporting

confidence: 55%

Cell Cycle Regulation by Post-Translational and Post-Transcriptional Mechanisms in an Anaerobic Extremist- the Anoxia Tolerant Turtle, Trachemys Scripta Elegans

Biggar¹

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“…Abstr. 1999, 25, 550. actively divide become relatively quiescent [83]. Attenuation of cellular proliferation in various tissues during torpor occurs in the G1 phase [84], the premitotic phase [85], or in other phases of the cell cycle as reviewed by Lyman [86].…”

Section: Other Mechanisms Related To Decreased Energy Demandmentioning

confidence: 99%

Potential for Discovery of Neuroprotective Factors in Serum and Tissue from Hibernating Species

Ross¹,

Drew²

2006

MRMC

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“…Hibernators appear facultatively to prevent mitosis at low temperatures to avoid chromosome damage (Jaroslow et al 1976; Kolaeva et al 1980; Kruman et al 1988a). DNA synthesis is also inhibited in ground squirrels throughout the hibernation season, even in the absence of torpor (Kruman et al 1986). In contrast, mitotic activity during intertorpor euthermic bouts may be higher than normal (Vinogradova 1988).…”

Section: Introductionmentioning

confidence: 99%

Does immune challenge affect torpor duration?

Burton

Reichman

1999

Functional Ecology

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Summary 1.Hibernation may alter the relationship between pathogens and their hosts; low host temperatures can prevent pathogen replication. Therefore, manipulating the timing and duration of torpor bouts could allow animals to gain an advantage over pathogens. 2. Thirty-two Turkish Hamsters (Mesocricetus brandti) were placed in short-day, cold conditions. After 10 weeks, 20 animals were challenged with an antigen to simulate a pathogen infection. Ten of these animals were returned to the cold ('cold-challenged'). The other 10 animals were placed in warm conditions ('warm-challenged'). Twelve animals received saline injections and were returned to the cold ('cold-control'). Coldchallenged animals spent significantly more time in torpor than did cold-control animals. 3. After 6·5 weeks, all animals were housed in warm conditions and ceased torpor. Both cold-challenged and warm-challenged animals received a second injection of antigen. There was no correlation between time spent euthermic and level of secondary humoral response of cold-challenged animals. The secondary humoral response of the cold-challenged animals was significantly lower than that of warm-challenged animals. 4. In this study immune status influenced torpor duration, and torpor caused immunosuppression. Hibernators may manipulate body temperature in order to combat pathogens while their own immune systems are suppressed.

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Seasonal variations of DNA synthesis in intestinal epithelial cells of hibernating animals—I. DNA synthesis in intestinal epithelial cells of ground squirrel (Citellus undulatus) during deep hibernation

Cited by 11 publications

References 8 publications

Cell Cycle Regulation by Post-Translational and Post-Transcriptional Mechanisms in an Anaerobic Extremist- the Anoxia Tolerant Turtle, Trachemys Scripta Elegans

Cell Cycle Regulation by Post-Translational and Post-Transcriptional Mechanisms in an Anaerobic Extremist- the Anoxia Tolerant Turtle, Trachemys Scripta Elegans

Potential for Discovery of Neuroprotective Factors in Serum and Tissue from Hibernating Species

Does immune challenge affect torpor duration?

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