Seasonal variations of adipose tissue in <i>Tupaia belangeri</i> (Mammalia: Scandentia: Tupaiidae)

Li, M.; Zhang, Hao; Zhu, Weiming; Wang, Zhengkun

doi:10.1080/24750263.2019.1572798

Cited by 11 publications

(7 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…WAT is the major energy reserve and will be mobilized to supply energy metabolism during increased physiological demand, such as prolonged cold acclimation. In addition, inguinal WAT will undergo browning, with increased UCP1 expression to produce heat uncoupling from ATP production, when animals are stimulated by cold [50]. Loss of classic iBAT in mice enhanced WAT browning [51], our research has similar results, which means iBAT removal induced browning of WAT.…”

Section: Effect Of Cold and Removal On Metabolic Phenotype Thermogene...supporting

confidence: 69%

Recruitment of Muscle Genes as an Effect of Brown Adipose Tissue Ablation in Cold-Acclimated Brandt’s Voles (Lasiopodomys brandtii)

Liu

Zhang

Wang

et al. 2022

IJMS

View full text Add to dashboard Cite

Skeletal muscle-based nonshivering thermogenesis (NST) plays an important role in the regulation and maintenance of body temperature in birds and large mammals, which do not contain brown adipose tissue (BAT). However, the relative contribution of muscle-based NST to thermoregulation is not clearly elucidated in wild small mammals, which have evolved an obligate thermogenic organ of BAT. In this study, we investigated whether muscle would become an important site of NST when BAT function is conditionally minimized in Brandt’s voles (Lasiopodomys brandtii). We surgically removed interscapular BAT (iBAT, which constitutes 52%~56% of total BAT) and exposed the voles to prolonged cold (4 °C) for 28 days. The iBAT-ablated voles were able to maintain the same levels of NST and body temperature (~37.9 °C) during the entire period of cold acclimation as sham voles. The expression of uncoupling protein 1 (UCP1) and its transcriptional regulators at both protein and mRNA levels in the iBAT of cold-acclimated voles was higher than that in the warm group. However, no difference was observed in the protein or mRNA levels of these thermogenesis-related markers except for PGC-1α in other sites of BAT (including infrascapular region, neck, and axilla) between warm and cold groups either in sham or iBAT-ablated voles. The iBAT-ablated voles showed higher UCP1 expression in white adipose tissue (WAT) than sham voles during cold acclimation. The expression of sarcolipin (SLN) and sarcoplasmic endoplasmic reticulum Ca2+-dependent adenosine triphosphatase (SERCA) in skeletal muscles was higher in cold than in warm, but no alteration in phospholamban (PLB) and phosphorylated-PLB (P-PLB) was observed. Additionally, there was increased in iBAT-ablated voles compared to that in the sham group in cold. Moreover, these iBAT-ablated voles underwent extensive remodeling of mitochondria and genes of key components related with mitochondrial metabolism. These data collectively indicate that recruitment of skeletal muscle-based thermogenesis may compensate for BAT impairment and suggest a functional interaction between the two forms of thermogenic processes of iBAT and skeletal muscle in wild small mammals for coping cold stress.

show abstract

Section: Effect Of Cold and Removal On Metabolic Phenotype Thermogene...supporting

confidence: 69%

Recruitment of Muscle Genes as an Effect of Brown Adipose Tissue Ablation in Cold-Acclimated Brandt’s Voles (Lasiopodomys brandtii)

Liu

Zhang

Wang

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…The study about Tupaia belangeri shows that RMR and the expression levels of pparα , pgc-1α , and PRDM16 increase significantly under cold acclimation, suggesting that browning may appear in WAT ( Hou et al, 2020 ). A genomic, proteomic, and morphological study of energy metabolism in highland pikas and Tupaia belangeri in summer and winter studies revealed that subcutaneous WAT in winter show BAT morphological and histological features ( Li et al, 2019 ). Furthermore, BAT-specific genes, such as UCP1 , Cox4 , and pgc-1α , are highly expressed in WAT in winter ( Li J. et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have found that at different altitudes, the life history strategies and personalities of plateau pika varied significantly ( Liu et al, 2012 ; Qu et al, 2013 ; Qu et al, 2019 ; Tan et al, 2020 ), accompanied by differences in fat accumulation and metabolic rate ( Yang et al, 2006 ). As ambient temperatures decrease, subcutaneous WAT “browned”, and adipose tissue heat production increased ( Bai et al, 2015 ; Li et al, 2019 ). However, studies on the expression of thermogenic genes in adipose tissue and other thermogenic tissues of plateau pika at different altitudes are limited.…”

Section: Introductionmentioning

confidence: 99%

Differential Expression of Metabolism-Related Genes in Plateau Pika (Ochotona curzoniae) at Different Altitudes on the Qinghai–Tibet Plateau

Zhu

Zhong

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

According to life history theory, animals living in extreme environments have evolved specific behavioral and physiological strategies for survival. However, the genetic mechanisms underpinning these strategies are unclear. As the highest geographical unit on Earth, the Qinghai–Tibet Plateau is characterized by an extreme environment and climate. During long-term evolutionary processes, animals that inhabit the plateau have evolved specialized morphological and physiological traits. The plateau pika (Ochotona curzoniae), one of the native small mammals that evolved on the Qinghai–Tibet Plateau, has adapted well to this cold and hypoxic environment. To explore the genetic mechanisms underlying the physiological adaptations of plateau pika to extremely cold ambient temperatures, we measured the differences in resting metabolic rate (RMR) and metabolism-related gene expression in individuals inhabiting three distinct altitudes (i.e., 3,321, 3,663, and 4,194 m). Results showed that the body mass and RMR of plateau pika at high- and medium-altitudes were significantly higher than those at the low-altitude. The expression levels of peroxisome proliferator-activated receptor α (pparα), peroxisome proliferator-activated receptor-γ coactivator-1α (pgc-1α), and the PR domain-containing 16 (PRDM16) in white (WAT) and brown (BAT) adipose tissues of plateau pika from high- and medium-altitudes were significantly higher than in pika from the low-altitude region. The enhanced expression levels of pgc-1α and pparα genes in the WAT of pika at high-altitude showed that WAT underwent “browning” and increased thermogenic properties. An increase in the expression of uncoupling protein 1 (UCP1) in the BAT of pika at high altitude indicated that BAT increased their thermogenic properties. The gene expression levels of pparα and pgc-1α in skeletal muscles were significantly higher in high-altitude pika. Simultaneously, the expression of the sarcolipin (SLN) gene in skeletal muscles significantly increased in high-altitude pika. Our results suggest that plateau pika adapted to an extremely cold environment via browning WAT, thereby activating BAT and enhancing SLN expression to increase non-shivering thermogenesis. This study demonstrates that plateau pika can increase thermogenic gene expression and energy metabolism to adapt to the extreme environments on the plateau.

show abstract

“…Traditionally, mammalian adipose tissue was classified as white and brown adipose tissues, but in recent years another adipose tissue called ‘beige’ was found, which differs from white adipose tissue (e.g., Li et al., 2019; Wang et al., 2014). White adipocytes have larger lipid drops and store energy in the form of triacylglycerols, secreting hormones and cytokines to regulate energy metabolism (Nedergaard et al., 2007); in contrast, brown adipocytes have smaller lipid drops and a greater number of mitochondria with UCP1, a mitochondrial carrier protein in their inner membrane, involved in the processes of generating heat.…”

Section: Discussionmentioning

confidence: 99%

The double skin of the pink fairy armadillo, the peculiar integumentary system of Chlamyphorus truncatus Cingulata (Mammalia, Xenarthra)

Krmpotic,

Scarano,

Andrés Laube

et al. 2023

Journal of Zoology

View full text Add to dashboard Cite

Chlamyphorus truncatus is the smallest known armadillo, weighing about 100 grams and measuring less than 15 cm from head to tail. It is endemic to central Argentina and the species is named after its unique carapace. This armadillo has almost completely subterranean habits and, unlike all other subterranean mammals, C. truncatus has a carapace composed of osteoderms and cornified scales. Furthermore, the skin and carapace show unique characteristics compared even with other armadillos. Owing to the reduced development of its eyes, it is important to analyse the skin morphology of this species, as well as specialized sensory organs like vibrissae. The aim of this contribution is to describe the histomorphology of the integumentary system of C. truncatus. For this, histological sections of the skin with and without osteoderms were made, and routine histological and immunohistochemical techniques were performed. Furthermore, microCTs were performed on osteoderms to describe their micromorphology. Our results show that the integumentary system presents unique characteristics compared to other armadillos, such as the peculiar skin under the dorsal shield and the flexibility of almost all of its carapace. Furthermore, the modification of the arrangement of hairs in the first pelvic buckler osteoderms may suggest biomechanical adaptations, such as an improvement in the displacement through the tunnels of sandy soils. The skin without osteoderms presents convergent characteristics with that of other subterranean mammals. Furthermore, the vibrissae conserve the structure of the armadillos (the cavernous sinuses extend throughout the follicle‐sinus complex) with a thinning and shortening of the hairs, which are probably linked to passive monitoring of the surrounding environment. Evidently, the adaptations of subterranean mammals to their environment imply structural and functional changes, which are both regressive and progressive in nature.

show abstract

Seasonal variations of adipose tissue in Tupaia belangeri (Mammalia: Scandentia: Tupaiidae)

Cited by 11 publications

References 44 publications

Recruitment of Muscle Genes as an Effect of Brown Adipose Tissue Ablation in Cold-Acclimated Brandt’s Voles (Lasiopodomys brandtii)

Recruitment of Muscle Genes as an Effect of Brown Adipose Tissue Ablation in Cold-Acclimated Brandt’s Voles (Lasiopodomys brandtii)

Differential Expression of Metabolism-Related Genes in Plateau Pika (Ochotona curzoniae) at Different Altitudes on the Qinghai–Tibet Plateau

The double skin of the pink fairy armadillo, the peculiar integumentary system of Chlamyphorus truncatus Cingulata (Mammalia, Xenarthra)

Contact Info

Product

Resources

About