Seasonal Variations in Haematological and Biochemical Parameters

Gidlow, David A; Church, John F; Clayton, Barbara E.

doi:10.1177/000456328602300311

Cited by 14 publications

(4 citation statements)

References 22 publications

(9 reference statements)

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“…In the elderly, T-Bil increases in the summer only in men, which is quite consistent with the findings of the current study. 24 The TP and Alb levels show inconsistent results, including no seasonal change 12,13 and a reduction in the spring and elevation in the summer has only been observed in women. 14,24 In addition to the drawbacks of the methods used in previous studies, inconsistencies in seasonal variation may be further attributable to various confounding factors.…”

Section: Discussionmentioning

confidence: 99%

“…In male workers undergoing medical checkups, however, the γ GT levels show a peak in March to May and a nadir in August to December, with a fluctuation range of 29%. 13 This seasonal variation may be caused by business-related alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

“…The AST levels showed no seasonal variation in male workers undergoing health checkups whereas the ALT levels showed a peak in April to June and a nadir in October to December, with 13% variation. 13 Neither AST nor ALT show any significant seasonal variation in young adults and elderly persons. 14 However, these studies measured only the AST and ALT three or four times a year.…”

Section: Fitted Functionmentioning

confidence: 93%

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Seasonal variation in liver function tests: a time-series analysis of outpatient data

Miyake¹,

Miyake²,

Kondo³

et al. 2009

Ann Clin Biochem

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Background: Long-term physiological variations, such as seasonal variations, affect the screening efficiency at medical checkups. This study examined the seasonal variation in liver function tests using recently described data-mining methods. Methods: The 'latent reference values' of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyltransferase (gGT), cholinesterase (ChE) and total bilirubin (T-Bil) were extracted from a seven-year database of outpatients (aged 20-79 yr; comprising approximately 1,270,000 test results). After calculating the monthly means for each variable, the time-series data were separated into trend and seasonal components using a local regression model (Loess method). Then, a cosine function model (cosinor method) was applied to the seasonal component to determine the periodicity and fluctuation range. A two-year outpatient database (215,000 results) from another hospital was also analysed to confirm the reproducibility of these methods. Results: The serum levels of test results tended to increase in the winter. The increase in AST and ALT was about 6% in men and women, and was greater than that in ChE, ALP (in men and women) and gGT (in men). In contrast, T-Bil increased by 3.6% (men) and 5.0% (women) in the summer. The total protein and albumin concentrations did not change significantly. AST and ALT showed similar seasonal variation in both institutions in the comparative analysis. Conclusions: The liver function tests were observed to show seasonal variations. These seasonal variations should therefore be taken into consideration when establishing either reference intervals or cut-off values, which are especially important regarding aminotransferases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Fitted Functionmentioning

confidence: 93%

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Seasonal variation in liver function tests: a time-series analysis of outpatient data

Miyake¹,

Miyake²,

Kondo³

et al. 2009

Ann Clin Biochem

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“…), individual's factors (exercise, physical activity, diet, etc.) [28][29][30][31][32][33][34]. Of note that is, the rainy season is the favorable time in diseases increase like malaria and other parasitic diseases not screen in this study.…”

Section: Biomed Research Internationalmentioning

confidence: 99%

Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea

Béavogui

Touré

Camara

et al. 2020

BioMed Research International

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Guinea’s reference ranges for biological parameters rely on those of Caucasian values. Variability in reference ranges according to the context is well-documented. We conducted this study for the purpose of future malaria clinical trials that assess the efficacy and safety of malaria drugs. A repeated cross-sectional study was carried out, in an apparently healthy cohort population. Surveys took place in Maferinyah rural community, which is located at 75 km from the capital. The 2.5th and 97.5th percentiles were determined nonparametrically and stood for reference intervals. Reference values were determined separately for males and females according to ranges of age (6-10 years of age; 11-15 years of age; 16-45 years of age). Differences between genders were tested using the Mann-Whitney test, while the Friedman test was performed to test differences within each gender group according to the seasons. A total of 450 volunteers were enrolled. The median age was 13. Males 16-45 years of age had significantly higher hematologic and biochemical values compared to a female of the same age (for hematological parameters: Mean Cell Hemoglobin Concentration MCHC p≤0.001, Platelets p≤0.001, monocytes p=0.0305, eosinophils p=0.0225; for biochemical parameters: Aspartate aminotransferase AST p≤0.001, Alanine Aminotransferase ALT p≤0.001, creatinine p≤0.001). We noticed significant seasonal variations for all the biochemical parameters and some hematologic parameters (Mean Corpuscular Hemoglobin MCH, MCHC, Mean Cell volume). This is the first study establishing hematologic and biochemical parameters in Guinea. These findings provide a useful guide for the clinical researchers and care providers. Studies on large scale and in different settings would be also desirable.

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Critical limits to define a lab adverse event during phase I studies: a study in 1134 subjects

Sibille¹,

Bresson

Janin

et al. 1997

European Journal of Clinical Pharmacology

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Seasonal Variations in Haematological and Biochemical Parameters

Cited by 14 publications

References 22 publications

Seasonal variation in liver function tests: a time-series analysis of outpatient data

Seasonal variation in liver function tests: a time-series analysis of outpatient data

Haematological and Biochemical Reference Values for Healthy Population of Maferinyah Rural Community in Guinea

Critical limits to define a lab adverse event during phase I studies: a study in 1134 subjects

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