Seasonal Variations in Atmospheric Pressure, Partial Oxygen Density, and Geomagnetic Activity as Additional Synchronizers of Circannual Rhythms

Kuzmenko, N. V.

doi:10.1134/s0006350919040080

Cited by 6 publications

(5 citation statements)

References 89 publications

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“…Our data also show that the assay is readily applicable to be performed in a hypoxia chamber and prove the O 2 level as a potential factor affecting the assay performance. Interestingly, according to the annual dynamics in the area, partial density of atmospheric O 2 noticeably decreases during the transition from winter to summer months ( Figure S4 ), similarly to the meteorological data for other cities [ 49 ]. Repetitive analysis of the cells showed that the GSH level in 3T3 fibroblasts but not in LN-229 cells was also significantly lowered in spring–summer compared to the winter period (data not shown).…”

Section: Discussionsupporting

confidence: 71%

Probing Cell Redox State and Glutathione-Modulating Factors Using a Monochlorobimane-Based Microplate Assay

et al. 2022

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Thiol compounds including predominantly glutathione (GSH) are key components of redox homeostasis, which are involved in the protection and regulation of mammalian cells. The assessment of cell redox status by means of in situ analysis of GSH in living cells is often preferable over established assays in cell lysates due to fluctuations of the GSH pool. For this purpose, we propose a microplate assay with monochlorobimane (MCB) as an available fluorescent probe for GSH, although poorly detected in the microplate format. In addition to the new procedure for improved MCB-assisted GSH detection in plate-grown cells and its verification with GSH modulators, this study provides a useful methodology for the evaluation of cell redox status probed through relative GSH content and responsiveness to both supplemented thiols and variation in oxygen pressure. The roles of extracellular interactions of thiols and natural variability of cellular glutathione on the assay performance were emphasized and discussed. The results are of broad interest in cell biology research and should be particularly useful for the characterization of pathological cells with decreased GSH status and increased oxidative status as well as redox-modulating factors.

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Section: Discussionsupporting

confidence: 71%

Probing Cell Redox State and Glutathione-Modulating Factors Using a Monochlorobimane-Based Microplate Assay

et al. 2022

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“…Our meta-analysis revealed a link between the seasonal dynamics of IS with annual fluctuations in atmospheric pressure, relative humidity, and ρO 2 . Moreover, ρO 2 in air (Mendeleev–Сlapeyron equation) as well as the partial pressure of alveolar oxygen 7,44 and oxygen saturation of hemoglobin depends on atmospheric pressure and relative humidity. 45,46 In regions where there is a significant decrease in atmospheric pressure in summer, the likelihood of IS in this season increases significantly compared to winter.…”

Section: Discussionmentioning

confidence: 99%

“…In regions with low humidity and stable low atmospheric pressure in summer, the risk of IS still shows a shift toward summer. 31,33 Based on Mendeleev–Сlapeyron equation, 7 atmospheric pressure largely, than humidity, determines ρO 2 in air. In addition, it has been found that a decrease in atmospheric pressure by 10 hPa is associated with an increase in the relative risk of deep vein thrombosis by 2.1%.…”

Section: Discussionmentioning

confidence: 99%

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Dependence of seasonal dynamics of hemorrhagic and ischemic strokes on the climate of a region: A meta-analysis

Kuzmenko

Galagudza

2021

International Journal of Stroke

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Background Cardiovascular events (CVEs) occur more often in winter than in summer; however, the dependence of strokes on various meteorological factors remains unclear . Aims The purpose of this meta-analysis was to determine the dependence of the circannual dynamics of hospitalizations for hemorrhagic stroke (HS) and ischemic stroke (IS) on seasonal fluctuations in meteorological factors. Summary of review and conclusions For our meta-analysis, we selected 20 and 26 publications examining the seasonal dynamics of HS and IS, respectively . The meta-analysis showed that HS occurs more often in winter than in other seasons and does not depend on a regionâs climate. The seasonal dynamics of IS are not clearly expressed and are determined by the characteristics of a regionâs climate. In a climate without pronounced seasonal dynamics of atmospheric pressure and in wet winters, the vector of IS incidents will not be expressed or slightly shifted toward winter. Low atmospheric pressure in summer is associated with an increased likelihood of IS during this season compared to winter. There was also a relation between IS risk with high relative humidity and a significant decrease in ÏO2 in summer, but there is not enough evidence regarding this association. We did not reveal dependence of the seasonal dynamics of strokes on the amplitude of annual fluctuations in air temperature. Keywords: ischemic stroke, hemorrhagic stroke, season, meteorological factors, climate

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“…Interestingly, alpine bumble bees were recorded above 5600 m, and they were shown to have the ability to maintain hovering flight under barometric pressures that occur above 9000-m elevations [ 92 ]. Analysis of latitudinal and seasonal variation in the partial density of oxygen in the air suggests that insects can also experience varying oxygen conditions on geographic and temporal timescales [ 94 ], but the biological significance of this type of variance needs to be studied. It is important to note here that prolonged exposure to hypoxia can affect insects in different ways than the acute hypoxia studied here, changing profiles of gene expression and protein production, the efficiency of ATP production, growth rates, development, the architecture of the tracheal system, cell size, and body size, among other features [ 48 , 95 ].…”

Section: Discussionmentioning

confidence: 99%

Oxygen Dependence of Flight Performance in Ageing Drosophila melanogaster

Privalova

Szlachcic

Sobczyk

et al. 2021

Biology

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Similar to humans, insects lose their physical and physiological capacities with age, which makes them a convenient study system for human ageing. Although insects have an efficient oxygen-transport system, we know little about how their flight capacity changes with age and environmental oxygen conditions. We measured two types of locomotor performance in ageing Drosophila melanogaster flies: the frequency of wing beats and the capacity to climb vertical surfaces. Flight performance was measured under normoxia and hypoxia. As anticipated, ageing flies showed systematic deterioration of climbing performance, and low oxygen impeded flight performance. Against predictions, flight performance did not deteriorate with age, and younger and older flies showed similar levels of tolerance to low oxygen during flight. We suggest that among different insect locomotory activities, flight performance deteriorates slowly with age, which is surprising, given that insect flight is one of the most energy-demanding activities in animals. Apparently, the superior capacity of insects to rapidly deliver oxygen to flight muscles remains little altered by ageing, but we showed that insects can become oxygen limited in habitats with a poor oxygen supply (e.g., those at high elevations) during highly oxygen-demanding activities such as flight.

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Seasonal Variations in Atmospheric Pressure, Partial Oxygen Density, and Geomagnetic Activity as Additional Synchronizers of Circannual Rhythms

Cited by 6 publications

References 89 publications

Probing Cell Redox State and Glutathione-Modulating Factors Using a Monochlorobimane-Based Microplate Assay

Probing Cell Redox State and Glutathione-Modulating Factors Using a Monochlorobimane-Based Microplate Assay

Dependence of seasonal dynamics of hemorrhagic and ischemic strokes on the climate of a region: A meta-analysis

Oxygen Dependence of Flight Performance in Ageing Drosophila melanogaster

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