Seasonal variation of serum vitamin D levels in Romania

Niculescu, D; Căpățînă, Cristina; Duşceac, Roxana; Caragheorgheopol, Andra; Ghemigian, Adina; Poiană, Cătălina

doi:10.1007/s11657-017-0407-3

“…As we all know, vitamin D3 is needed from not only adequate intake from diet or supplements but also biosynthesis in the skin in response to su cient exposure to sunlight. Several studies have concerned seasonal variation in serum 25(OH)D concentrations [29,30,31]. This study also found that serum 25(OH)D concentration was the lowest in January and the highest in July and August.…”

Section: General Characteristics Of Participant Womensupporting

confidence: 58%

Serum 25 hydroxyvitamin D levels and affecting factors among preconception fertile women

Fan

¹

,

Hui

²

,

Yan

³

et al. 2020

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0

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Background: Recent study found that vitamin D before conception was considered as a potential additional determinant for achieving pregnancy and live births. The study aimed to evaluate the serum 25 hydroxyvitamin D (25(OH)D) levels and its affecting factors among preconception fertile women. Methods: This cross-sectional study enrolled 410 women aged 22-44 years who attended a preconception genetic counseling clinic from January 2018 to May 2019. Sociodemographic characteristics and reproductive history of women were collected, and height and weight were measured. Serum 25(OH)D concentration was assayed with chemiluminescence immunoassay. Descriptive statistics were used to examine serum 25(OH)D concentration, and socio-demographic characteristics and reproductive history among preconception women. Determinants of vitamin D deficiency and its affecting factors were assessed using χ2 test. Results: Findings showed 84.4% of women had serum 25(OH)D concentration below 20 ng/mL. Women working indoors as well as without a history of childbirth had significantly lower 25(OH)D levels compared with those non-working individuals and having delivered a previous child (both P <0.05). The 25(OH)D levels were the lowest in winter than in spring, summer, and autumn (all P <0.001). Women in winter have significantly elevated OR of 5.00 (95%CI 1.75–14.25) to develop vitamin D deficiency. Seasonal variation in serum 25(OH)D levels was not present in non-working individuals and women aged 31-44 years. Conclusions: Vitamin D deficiency is common among preconception women especially nulliparous women and working women, which propose to screen serum 25(OH)D on preconception evaluation and emphasize need vitamin D supplements and get sunshine exposure.

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“…As we all know, vitamin D3 is needed from not only adequate intake from diet or supplements but also biosynthesis in the skin in response to sufficient exposure to sunlight. Several studies have concerned seasonal variation in serum 25(OH)D concentrations [29,30,31]. This study also found that serum 25 intake of vitamin D compensated for decreased ultraviolet radiation B exposure [34].…”

Section: General Characteristics Of Participant Womensupporting

confidence: 56%

Serum 25 hydroxyvitamin D levels and affecting factors among preconception fertile women

Fan

¹

,

Hui

²

,

Yan

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background: Recent study found that vitamin D before conception was considered as a potential additional determinant for achieving pregnancy and live births. The study aimed to evaluate the serum 25 hydroxyvitamin D (25(OH)D) levels and its affecting factors among preconception fertile women. Methods: This cross-sectional study enrolled 410 women aged 22-44 years who attended a preconception genetic counseling clinic from January 2018 to May 2019. Sociodemographic characteristics and reproductive history of women were collected, and height and weight were measured. Serum 25(OH)D concentration was assayed with chemiluminescence immunoassay. Descriptive statistics were used to examine serum 25(OH)D concentration, and socio-demographic characteristics and reproductive history among preconception women. Determinants of vitamin D deficiency and its affecting factors were assessed using χ2 test. Results: Findings showed 84.4% of women had serum 25(OH)D concentration below 20 ng/mL. Women working indoors as well as without a history of childbirth had significantly lower 25(OH)D levels compared with those non-working individuals and having delivered a previous child (both P <0.05). The 25(OH)D levels were the lowest in winter than in spring, summer, and autumn (all P <0.001). Women in winter have significantly elevated OR of 5.00 (95%CI 1.75–14.25) to develop vitamin D deficiency. Seasonal variation in serum 25(OH)D levels was not present in non-working individuals and women aged 31-44 years. Conclusions: Vitamin D deficiency is common among preconception women especially nulliparous women and working women, which propose to screen serum 25(OH)D on preconception evaluation and emphasize need vitamin D supplements and get sunshine exposure.

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“…(a) comparison of the vitamin D levels in cases without ED versus with ED (subgroup vitamin D detection methods); (b) comparison of the vitamin D levels in cases without ED versus with ED (subgroup sample size >1,000 and sample size <1,000); (c) comparison of IIEF-5 score in cases without vitamin D deficiency versus with vitamin D deficiency (subgroup vitamin D detection methods); (d) comparison of IIEF-5 score in cases without vitamin D deficiency versus with vitamin D deficiency (subgroup sample size >100 and sample size <100) intake and sun exposure (latitude, climate, personal or cultural habits of sun bathing, clothing). Generally, the serum vitamin D concentrations vary with season in subjects of all age, being lowest during winter and early spring, highest in summer (Niculescu et al, 2017). Only one study has provided the differential seasonal data (Sudarevic et al, 2017); we were unable to perform this specific analysis based on this seasonal variation, because most study failed to provide the related data.…”

Section: Discussionmentioning

confidence: 94%

“…Generally, the serum vitamin D concentrations vary with season in subjects of all age, being lowest during winter and early spring, highest in summer (Niculescu et al, 2017). (a) comparison of the vitamin D levels in cases without ED versus with ED (subgroup vitamin D detection methods); (b) comparison of the vitamin D levels in cases without ED versus with ED (subgroup sample size >1,000 and sample size <1,000); (c) comparison of IIEF-5 score in cases without vitamin D deficiency versus with vitamin D deficiency (subgroup vitamin D detection methods); (d) comparison of IIEF-5 score in cases without vitamin D deficiency versus with vitamin D deficiency (subgroup sample size >100 and sample size <100) intake and sun exposure (latitude, climate, personal or cultural habits of sun bathing, clothing).…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D levels and erectile dysfunction: A systematic review and meta-analysis

Wei

¹

,

Chen

²

,

Zhu

³

2018

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Suboptimal levels of serum vitamin D levels have been implied to be associated with cardiovascular diseases and endothelial dysfunction, conditions closely associated with erectile dysfunction (ED). The present systematic review and meta-analysis was performed to evaluate the vitamin D levels in subjects with ED compared to controls and the 5-item version of the international index of erectile function (IIEF-5) score in subjects with vitamin D deficiency compared to those without vitamin D deficiency in order to elucidate the role of vitamin D in the pathogenesis of ED. Studies evaluating the possible association between vitamin D levels and ED were initially screened and thus included following electronic literature search of database Cochrane Library, PUBMED, EMBASE and MEDLINE. Essential article information including outcome measures was extracted from the qualified studies by two independent authors, and STATA 12.0 software was used conducted the meta-analysis. Subgroup analyses were conducted by vitamin D detection methods and sample size. The standard mean difference (SMD) as well as the 95% confidence intervals (95% CIs) was applied to estimate the outcome measures. A total of seven articles were included in our meta-analysis with a total of 4,132 subjects. Pooled estimate was in favour of increased vitamin D levels in subjects without ED with a SMD of 3.027 ng/ml, 95%CI 2.290-3.314, p = 0.000. However, subgroup analysis showed an opposite trend, after one study with a sample size over 1,000 that could possibly influence the weight balance was excluded, with a SMD of 0.267, 95%CI −0.052 to 0.585, p = 0.101. We also identified about 0.320 higher in IIEF-5 score (95%CI = 0.146-0.494, p = 0.000) in subjects without vitamin D deficiency versus with vitamin D deficiency. Nevertheless, subgroup analysis based on vitamin D detection methods obtained differential results (radioimmunoassay subgroup, SMD(95%CI) = 0.573 (0.275-0.870), p = 0.000; immunoassay subgroup, SMD(95%CI) = 0.189 (−0.025 to 0.404), p = 0.084). In conclusion, results from the present meta-analysis did not provide a strong relationship between vitamin D and the risk of ED. However, the results should be interpreted with caution and more high quality studies are warranted. K E Y W O R D S5-item version of the international index of erection function, erectile dysfunction, metaanalysis of VD and ED, meta-analysis, vitamin D

show abstract

Seasonal variation of serum vitamin D levels in Romania

Abstract: The prevalence of vitamin D deficiency is high, particularly in the elderly. The data show a strong seasonal variation of serum 25(OH)D in all subgroups of our Romanian population with highest levels in September and lowest levels in March.

Cited by 57 publications

References 26 publications

Serum 25 hydroxyvitamin D levels and affecting factors among preconception fertile women

Serum 25 hydroxyvitamin D levels and affecting factors among preconception fertile women

Serum 25 hydroxyvitamin D levels and affecting factors among preconception fertile women

Serum vitamin D levels and erectile dysfunction: A systematic review and meta-analysis

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