Seasonal variation of metabolism in lizard Phrynocephalus vlangalii at high altitude

Liang, Shi-wei; Li, Weixin; Zhang, Yang; Tang, Xiaolong; He, Jianzheng; Bai, Yucheng; Li, Dongqin; Yan, Wang; Chen, Qiang

doi:10.1016/j.cbpa.2016.10.010

Cited by 10 publications

(5 citation statements)

References 47 publications

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“…Exposure to higher‐than‐normal temperatures can increase the ratio of mitochondrial ROS/ATP production (Roussel & Voituron, 2020) and induce oxidative damage associated with certain mitochondrial phenotypes (Pichaud et al, 2020). For example, mitochondrial function can differ across geographical thermal clines and with mitochondrial genotypes (Coyle et al, 2019; Faria et al, 2020; Fitzpatrick et al, 2019) and change through acclimation effects across seasons (Liang et al, 2017). Indeed, cold acclimation in some species increases mitochondrial enzyme activities and thus the flux through the mitochondrial electron transport chain and ATP production (increased ATP/oxygen ratio) can be elevated at low temperatures (Chung & Schulte, 2015), which would potentially increase ROS production (Loughland & Seebacher, 2020).…”

Section: Thermal Effects At the Level Of The Cell: Links To Telomere ...mentioning

confidence: 99%

“…Exposure to higher-than-normal temperatures can increase the ratio of mitochondrial ROS/ATP production (Roussel & Voituron, 2020) and induce oxidative damage associated with certain mitochondrial phenotypes (Pichaud et al, 2020). For example, mitochondrial function can differ across geographical thermal clines and with mitochondrial genotypes (Coyle et al, 2019;Faria et al, 2020;Fitzpatrick et al, 2019) and change through acclimation effects across seasons (Liang et al, 2017). Indeed, cold acclimation in F I G U R E 4 Thermal performance curves (TPCs) for several performances in within an individual organism, or the mean of a population or of a species in a particular thermal environment: antioxidant activity, mitochondrial function, telomerase activity, general cellular metabolism and growth.…”

Section: Mitochondriamentioning

confidence: 99%

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Of telomeres and temperature: Measuring thermal effects on telomeres in ectothermic animals

2021

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Ectotherms are classic models for understanding life‐history tradeoffs, including the reproduction–somatic maintenance tradeoffs that may be reflected in telomere length and their dynamics. Importantly, life‐history traits of ectotherms are tightly linked to their thermal environment, with diverse or synergistic mechanistic explanations underpinning the variation. Telomere dynamics potentially provide a mechanistic link that can be used to monitor thermal effects on individuals in response to climatic perturbations. Growth rate, age and developmental stage are all affected by temperature, which interacts with telomere dynamics in complex and intriguing ways. The physiological processes underpinning telomere dynamics can be visualized and understood using thermal performance curves (TPCs). TPCs reflect the evolutionary history and the thermal environment during an individual's ontogeny. Telomere maintenance should be enhanced at or near the thermal performance optimum of a species, population and individual. The thermal sensitivity of telomere dynamics should reflect the interacting TPCs of the processes underlying them. The key processes directly underpinning telomere dynamics are mitochondrial function (reactive oxygen production), antioxidant activity, telomerase activity and telomere endcap protein status. We argue that identifying TPCs for these processes will significantly help design robust, repeatable experiments and field studies of telomere dynamics in ectotherms. Conceptually, TPCs are a valuable framework to predict and interpret taxon‐ and population‐specific telomere dynamics across thermal regimes. The literature of thermal effects on telomeres in ectotherms is sparse and mostly limited to vertebrates, but our conclusions and recommendations are relevant across ectothermic animals.

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Section: Thermal Effects At the Level Of The Cell: Links To Telomere ...mentioning

confidence: 99%

Section: Mitochondriamentioning

confidence: 99%

Of telomeres and temperature: Measuring thermal effects on telomeres in ectothermic animals

2021

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“…In turn, the pre-adapted hump-snout whitefish after thermal exposure shows no significant changes in the FAM level (Figure 4) compared to the non-adapted hump-snout whitefish (Figure 4). This could be due to the fact that mitochondrial function may change due to membrane fluidity and remodeling of these membranes during preconditioning (homeoviscous adaptation) [84,88], as previously suggested when studying the effects of natural acclimation across different seasons [89]. In particular, abalone (genus Haliotis) and tube worms (Riftia pachyptila) exhibit enhanced mitochondrial membrane fluidity in response to brief temperature changes, which correlates with changes in the respiratory capacity of mitochondria under the influence of temperature [84,90,91].…”

Section: Effects Of Heat Shock On Mitochondria Telomerase Activity An...mentioning

confidence: 84%

“…Previous observations also show that several compounds affect mitochondrial resistance, including the telomerase protein, which provides protection against stress-induced mitochondrial loading [11,89,92,93]. Specifically, telomerase can protect cells from damage by ROS by binding to mitochondrial DNA and mitochondrial transfer RNA, since reverse transcriptase is frequently located in mitochondria, whereas telomerase RNA is often found in the cytoplasm [94][95][96].…”

Section: Effects Of Heat Shock On Mitochondria Telomerase Activity An...mentioning

confidence: 98%

Thermal Preconditioning Alters the Stability of Hump-Snout Whitefish (Coregonus fluviatilis) and Its Hybrid Form, Showing Potential for Aquaculture

Sapozhnikova,

Koroleva,

Yakhnenko

et al. 2023

Biology

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One of the little-studied ways that climate warming or temperature increases in aquaculture could affect aquatic animals is through accelerated aging. This study is dedicated to understanding the principles of molecular and cellular aging in the target tissues of juvenile whitefishes (Yenisei hump-snout whitefish and its hybrid) under the influence of acute heat stress (up to 26 °C), and the effects of thermal preconditioning as pre-adaptation. Non-adapted stressed hump-snout whitefish showed a higher induction threshold for functionally active mitochondria in the blood and a decrease in telomerase activity in the liver after heat shock exposure as a long-term compensatory response to prevent telomere shortening. However, we observed heat-induced telomere shortening in non-adapted hybrids, which can be explained by a decrease in mitochondrial membrane stability and a gradual increase in energy demand, leading to a decrease in protective telomerase activity. The pre-adapted groups of hump-snout whitefish and hybrids showed a long-term or delayed response of telomerase activity to heat shock, which served as a therapeutic mechanism against telomere shortening. We concluded that the telomerase and telomere responses to thermal stress demonstrate plasticity of tolerance limits and greater stability in hump-snout whitefish compared with hybrids.

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“…Moreover, acclimatization and adaptation to hypoxia was explored in high- and low-altitude P. vlangalii and showed that hemoglobin concentration, hematocrit, heart weight to body mass, and succinate dehydrogenase activity were all markedly higher at high altitude [ 24 ]. High-altitude P. vlangalii can also adjust energy metabolism to adapt to seasonal environmental changes, including their preferred body temperature, standard metabolic rate, mitochondrial respiration rate, and metabolic enzyme activities [ 25 ]. However, the metabolic regulation of adaptation to high altitude is not fully understood, and therefore, assessing metabolic profiles of liver via a multi-platform metabolomic analysis could expand our understanding of the adaptive phenotypes that support life at high altitude.…”

Section: Introductionmentioning

confidence: 99%

Comparative metabolomics analysis reveals high-altitude adaptations in a toad-headed viviparous lizard, Phrynocephalus vlangalii

Zhang,

Men,

Jia

et al. 2023

Front Zool

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Extreme environmental conditions at high altitude, such as hypobaric hypoxia, low temperature, and strong UV radiation, pose a great challenge to the survival of animals. Although the mechanisms of adaptation to high-altitude environments have attracted much attention for native plateau species, the underlying metabolic regulation remains unclear. Here, we used a multi-platform metabolomic analysis to compare metabolic profiles of liver between high- and low-altitude populations of toad-headed lizards, Phrynocephalus vlangalii, from the Qinghai–Tibet Plateau. A total of 191 differential metabolites were identified, consisting of 108 up-regulated and 83 down-regulated metabolites in high-altitude lizards as compared with values for low-altitude lizards. Pathway analysis revealed that the significantly different metabolites were associated with carbohydrate metabolism, amino acid metabolism, purine metabolism, and glycerolipid metabolism. Most intermediary metabolites of glycolysis and the tricarboxylic acid cycle were not significantly altered between the two altitudes, but most free fatty acids as well as β-hydroxybutyric acid were significantly lower in the high-altitude population. This may suggest that high-altitude lizards rely more on carbohydrates as their main energy fuel rather than lipids. Higher levels of phospholipids occurred in the liver of high-altitude populations, suggesting that membrane lipids may undergo adaptive remodeling in response to low-temperature stress at high altitude. In summary, this study demonstrates that metabolic profiles differ substantially between high- and low-altitude lizard populations, and that these differential metabolites and metabolic pathways can provide new insights to reveal mechanisms of adaptation to extreme environments at high altitude.

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Seasonal variation of metabolism in lizard Phrynocephalus vlangalii at high altitude

Cited by 10 publications

References 47 publications

Of telomeres and temperature: Measuring thermal effects on telomeres in ectothermic animals

Of telomeres and temperature: Measuring thermal effects on telomeres in ectothermic animals

Thermal Preconditioning Alters the Stability of Hump-Snout Whitefish (Coregonus fluviatilis) and Its Hybrid Form, Showing Potential for Aquaculture

Comparative metabolomics analysis reveals high-altitude adaptations in a toad-headed viviparous lizard, Phrynocephalus vlangalii

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