Seasonal Variation in the Incidence of Gastroesophageal Reflux Disease

Chen, Kuan-Yang; Lin, Herng‐Ching; Lou, Horng-Yuan; Lee, Shu‐Hui

doi:10.1097/maj.0b013e3181b51fbd

Cited by 17 publications

(15 citation statements)

References 22 publications

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“…The validity of findings from this large-scale nationwide survey is increased through the minimization of selection bias and complete follow-up of cases. Recall bias was avoided by using a recorded history of GERD, which requires diagnostic evidence of either endoscopy or 24-h pH-meter inspection prior to treatment with proton pump inhibitors [14][15][16]. Furthermore, data regarding cancer diagnosis can be regarded as exhaustive and reliable because it was linked to the Catastrophic Illness Registry, which requires histopathologic proof of malignancy before certification [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Acid reflux and head and neck cancer risk: A nationwide registry over 13 years

Kuo¹,

Chen²,

Shiao³

et al. 2015

Auris Nasus Larynx

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Section: Discussionmentioning

confidence: 99%

Acid reflux and head and neck cancer risk: A nationwide registry over 13 years

Kuo¹,

Chen²,

Shiao³

et al. 2015

Auris Nasus Larynx

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“…First, the diagnoses of GERD are identified using the ICD-9 codes from the database, and its prevalence may be underestimated because only subjects seeking medical evaluation can be identified by our study. This study was conducted with Taiwan's NHI database, in which the diagnosis was supposed to be confirmed clinically by the individual physicians in charge [14], [18]. Second, subtypes of AF (paroxysmal, persistent or permanent) can not be classified because of the lack of specific ICD-9 codes.…”

Section: Discussionmentioning

confidence: 99%

“…The Bureau of National Health Insurance requires that GERD patients be diagnosed by either endoscopy or 24-hour pH-meter inspection before proton pump inhibitor (PPI) can be prescribed for treatment. The diagnoses of GERD are valid, and this criteria has been used in similar studies [14], [18]. A control group was selected from patients without a history of esophageal diseases or arrhythmia.…”

Section: Methodsmentioning

confidence: 99%

Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study

et al. 2012

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ObjectivesPrecise mechanisms of atrial fibrillation (AF) are uncertain, but their association with esophageal disorders has been recently proposed. The association between gastroesophageal reflux disease (GERD), the most common gastroesophageal disorder, and AF remains undetermined. We therefore aimed to investigate the association between GERD and later development of AF.Methods and ResultsPatients with GERD were identified from the 1,000,000-person cohort dataset sampled from the Taiwan National Health Insurance database. The study cohort comprised 29,688 newly diagnosed adult GERD patients; 29,597 randomly selected age-, gender-, comobidity-matched subjects comprised the comparison cohort. Cox proportional hazard regressions were performed as a means of comparing the AF-free survival rate for the two cohorts. During a maximum three years of follow-up, a total of 351 patients experienced AF, including 184 (0.62%) patients in the GERD cohort and 167 (0.56%) in the control group. The log-rank test showed that patients with GERD had significantly higher incidence of AF than those without GERD (p = 0.024). After Cox proportional hazard regression model analysis, GERD was independently associated with the increased risk of AF (hazard ratio, 1.31; 95% confidence interval, 1.06–1.61, p = 0.013).ConclusionGERD was independently associated with an increased risk of future AF in a nationwide population-based cohort.

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“…The Bureau of National Health Insurance requires that GERD patients be diagnosed by either endoscopy or 24-hour pH-meter inspection before PPIs can be prescribed for treatment. The criteria has been used in similar studies [11], thus the diagnoses of GERD are valid. For each patient in GERD cohort, 5 subjects without GERD matched for age, gender, comorbidities, index year via propensity score matching were included as the comparison cohort.…”

Section: Methodsmentioning

confidence: 99%

Risk of acute myocardial infarction in patients with gastroesophageal reflux disease: A nationwide population-based study

et al. 2017

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ObjectiveGastroesophageal reflux disease (GERD) is a common disease which can cause troublesome symptoms and affect quality of life. In addition to esophageal complications, GERD may also be a risk factor for extra-esophageal complications. Both GERD and coronary artery disease (CAD) can cause chest pain and frequently co-exist. However, the association between GERD and acute myocardial infarction (AMI) remain unclear. The purpose of the study was to compare the incidence of acute myocardial infarction in GERD patients with an age-, gender-, and comorbidity matched population free of GERD. We also examine the association of the risk of AMI and the use of acid suppressing agents in GERD patients.MethodsWe identified patients with GERD from the Taiwan National Health Insurance Research Database. The study cohort comprised 54,422 newly diagnosed GERD patients; 269,572 randomly selected age-, gender-, comorbidity-matched subjects comprised the comparison cohort. Patients with any prior CAD, AMI or peripheral arterial disease were excluded. Incidence of new AMI was studied in both groups.ResultsA total 1,236 (0.5%) of the patients from the control group and 371 (0.7%) patients from the GERD group experienced AMI during a mean follow-up period of 3.3 years. Based on Cox proportional-hazard model analysis, GERD was independently associated with increased risk of developing AMI (hazard ratio (HR) = 1.48; 95% confidence interval (CI): 1.31–1.66, P < 0.001). Within the GERD group, patients who were prescribed proton pump inhibitors (PPIs) for more than one year had slightly decreased the risk of developing AMI, compared with those without taking PPIs (HR = 0.57; 95% CI: 0.31–1.04, P = 0.066).ConclusionsThis large population-based study demonstrates an association between GERD and future development of AMI, however, PPIs use only achieved marginal significance in reducing the occurrence of AMI in GERD patients. Further prospective studies are needed to evaluate whether anti-reflux medication may reduce the occurrence of acute ischemic event in GERD patients.

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Seasonal Variation in the Incidence of Gastroesophageal Reflux Disease

Cited by 17 publications

References 22 publications

Acid reflux and head and neck cancer risk: A nationwide registry over 13 years

Acid reflux and head and neck cancer risk: A nationwide registry over 13 years

Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study

Risk of acute myocardial infarction in patients with gastroesophageal reflux disease: A nationwide population-based study

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