Seasonal Variation in the Incidence of Deep Vein Thrombosis in Patients With Deficiency of Protein C or Protein S

Bilora, Franca; Boccioletti, Veronica; Manfredini, E.; Petrobelli, Francesco; Tormene, Daniela; Simioni, P.; Girolami, Antonio

doi:10.1177/107602960200800306

Cited by 17 publications

(23 citation statements)

References 14 publications

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“…A total of 106 among the 129 studies were excluded for the reasons as follows: five studies 15–19 failed to provide data aggregated on monthly and seasonal retrieval, seven reported insufficient data, 15 were commentary literature or reviews, and 55 cannot meet the inclusion criteria. Finally, it was identified that 23 eligible studies 7–9,20–39 met the inclusion criteria of the meta-analysis, including 40,309 patients with VTE including PE, DVT, or SVT. Figure 1 summarizes the selection flow and inclusion process of the study.…”

Section: Resultsmentioning

confidence: 99%

“…Second, many single-center studies with small population of patients were included, which could certainly influence the meta-analysis results. For instance, some of the selected studies had fewer than 100 patients, 7,35 whereas another had 19,245 patients. 31 Third, this meta-analysis results may be influenced by different definitions of the seasons in various countries.…”

Section: Discussionmentioning

confidence: 99%

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Seasonal variation in the frequency of venous thromboembolism: An updated result of a meta-analysis and systemic review

Zhao

et al. 2020

Phlebology

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Objective Venous thromboembolism, including deep vein thrombosis and pulmonary embolism, is likely to cause the death of both medical and surgical patients. Despite some evidence of seasonal variation in the incidence of venous thromboembolism, the existing studies obtain contradictory results. A temporal pattern for pulmonary embolism is known, but data on deep vein thrombosis are inconclusive. The purpose of this study is to make a meta-analysis and systematically review the literature about seasonal variations of pulmonary embolism and/or deep vein thrombosis in order to objectively diagnose venous thromboembolism. Methods According to dichotomous data, risk ratios (RRs) and 95% confidence intervals (CIs) were used to compare the incidence of venous thromboembolism in different seasons. The research was classified according to pulmonary embolism mortality, pulmonary embolism/deep vein thrombosis incidence, latitude/elevation/climatic types, and monthly incidence for four subgroup comparisons. There were a total of 23 eligible studies, in which 40,309 patients with venous thromboembolism were compared. Results The pooled total venous thromboembolism incidence was 27.2% in winter, 23.1% in spring, 24.6% in summer, and 25.1% in autumn. According to the results of pooled analysis, the incidence of venous thromboembolism in winter was much higher than that in summer (RR = 1.12, 95% CI: 1.01–1.24, adjusted P = .04), especially deep vein thrombosis. Moreover, the incidence of venous thromboembolism in summer and autumn was lower than that in winter in low-latitude (<200 m) areas and median low-latitude (0–50°-N) areas. Interestingly, the frequency of pulmonary embolism mortality was the largest in spring and smallest in summer (spring > winter ≈ autumn > summer). For monthly data, a statistically significantly lower incidence of venous thromboembolism was observed in May and July than in October. Conclusions The study revealed a significantly higher incidence of venous thromboembolism and deep vein thrombosis in winter than in summer. Pulmonary embolism mortality occurred more frequently in spring than during other seasons. A statistically significantly lower incidence of venous thromboembolism was observed in May and July compared with that in October.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Seasonal variation in the frequency of venous thromboembolism: An updated result of a meta-analysis and systemic review

Zhao

et al. 2020

Phlebology

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“…Although controversial results have been reported about the seasonal variation of LLTE incidence, most of the published studies have reported a larger incidence of LLTE during the winter season. [1][2][3][4][5][6][7][8][9] This higher risk of DVT or LLTE in winter has been suggested to result from meteorological influences, such as temperature, wind speed, air pollution, 1,13 and atmospheric pressure changes, 14 reduced physical activity, 8 birth period, 15 dehydration, 16 seasonal infections, 17 or change in lifestyle during holidays. 13 Among all parameters discussed, ambient temperature is of specific interest since blood flow in muscles (assumed to be collected by the deep veins) is not influenced by thermal regulation, whereas skin blood flow (assumed to be collected by superficial veins) is.…”

Section: Discussionmentioning

confidence: 99%

“…Seasonal variations of lower-limb venous thrombotic events (LLTE) incidence have been largely studied, and most studies suggest a higher occurrence of deep venous thrombosis (DVT) during the winter months. [1][2][3][4][5][6][7][8][9][10] In fact, for many studies, the number of diagnosed LLTE and the resulting apparent incidence is likely to be partly related to health care providers availability which is reduced during summer holidays (in the northern hemisphere). This latter factor is of particular weight in prospective studies for which patients' inclusion in experimental protocols is difficult when reduced personnel in medical care center is already responsible for tensions in the healthcare system.…”

Section: Introductionmentioning

confidence: 99%

The risk of lower-limb superficial vein thrombosis relative to lower-limb venous thrombotic events is not increased in winter months

Henni

Ramondou²,

Duval

et al. 2020

Phlebology

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Objectives Ambient temperature (that impacts differently venous flow in superficial and deep veins) could have a different effect on the risk of superficial and deep venous thrombosis. We searched for a trimestral variation of the risk of superficial venous thrombosis among all lower-limb thrombotic events (lower-limb thrombotic events = superficial venous thrombosis + deep venous thrombosis). Methods We retrospectively analyzed the results of venous ultrasound investigations performed among 11,739 patients (aged 67 ± 19 years old, 56.1% males) referred for suspected lower-limb thrombotic events over a 12-year period. Chi-square test was used to compare the superficial venous thrombosis/lower-limb thrombotic events ratio observed by trimesters to a homogeneous distribution. Results The proportion of lower-limb thrombotic events were 30.7%, 28.8%, 31.1%, and 31.4% (Chi2: 0.133; p = 0.987) of total investigations, while that of superficial venous thrombosis among all lower-limb venous thrombotic events were 27.2%, 30.0%, 31.4%, and 31.0%, for the first, second, third, and fourth trimesters respectively (Chi2: 0.357; p: 0.949). Conclusion No trimestral variation of the superficial venous thrombosis/lower-limb venous thrombotic events ratio was observed.

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“…As we know the subjects are more prone to thromboembolism. The frequency of the DVT (and/or VTE) in these subjects significantly increases in the autumn (November) (37). Results from the Korean registry (38) has shown a raised frequency in DVT diagnoses both in autumn and winter compared to the hot seasons.…”

Section: Effect Of Climatementioning

confidence: 95%

Deep vein thrombosis related to environment

Signorelli

Ferrante

Gaudio

et al. 2017

Molecular Medicine Reports

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The first-time venous thromboembolism (VTE) is less frequent than other thrombotic events, however, both the pulmonary embolism (PE) and the deep vein thrombosis (DVT) show a frequent morbidity. Many factors play as risk situations in determining VTE, and the air exposure to the fine and ultrafine particulate matter (PM) as PM10, PM2.5, PM0.1 is considered. Epidemiological studies have supported this association although both the effective burden of the association and the mechanisms are to date unclear. The PM concentrations and the exposure time are notable as emerging factors. Interestingly, the seasonal climate variations resulted as effective risk factor for appearance of VTE or DVT. There is a need to ameliorate the environment by reducing the air pollution at global scale.

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Seasonal Variation in the Incidence of Deep Vein Thrombosis in Patients With Deficiency of Protein C or Protein S

Cited by 17 publications

References 14 publications

Seasonal variation in the frequency of venous thromboembolism: An updated result of a meta-analysis and systemic review

Seasonal variation in the frequency of venous thromboembolism: An updated result of a meta-analysis and systemic review

The risk of lower-limb superficial vein thrombosis relative to lower-limb venous thrombotic events is not increased in winter months

Deep vein thrombosis related to environment

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