“…It is, however, well known that in female frogs maintained at temperatures above 15-18 C. for several weeks there is a rapid consumption of the fat bodies and even of the eggs within the ovaries (Rugh, 1935) It has been demonstrated by Sims and Bishop (1947) that the pituitary gland of Rana pipicns does undergo seasonal variations, increasing in gonadotropic potency between January and March. The possibility that pituitary hormones are increasing during the breeding season and affecting the adrenal cortical hormone balance, which in turn brings about an increase in enzyme activity, seems to be negated by the decrease in activity following pituitary injection.…”