Seasonal variation in sex-specific immunity in wild birds

Valdebenito, José O.; Halimubieke, Naerhulan; Lendvai, Ádám Z.; Figuerola, Jordi; Eichhorn, Götz; Székely, Tamás

doi:10.1038/s41598-020-80030-9

Cited by 36 publications

(49 citation statements)

References 92 publications

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“…As the immune cells differentiation and function crucially depend on mitochondrial bioenergetics ( 15 , 16 ), sex differences in mitochondrial functions have a potential to modulate immune responses. Differences in immune responses have been observed also between males and females of other mammals ( 17 – 19 ), birds ( 20 ), reptiles ( 21 ), echinoderms ( 22 ) and insects ( 23 ). Such baseline differences can contribute to sex biases in response to pathogens (24,25 and see the next section) and to vaccination ( 2 – 6 ).…”

Section: Introductionmentioning

confidence: 99%

Gene-Specific Sex Effects on Susceptibility to Infectious Diseases

Lipoldová

Démant

2021

Front. Immunol.

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Inflammation is an integral part of defense against most infectious diseases. These pathogen-induced immune responses are in very many instances strongly influenced by host’s sex. As a consequence, sexual dimorphisms were observed in susceptibility to many infectious diseases. They are pathogen dose-dependent, and their outcomes depend on pathogen and even on its species or subspecies. Sex may differentially affect pathology of various organs and its influence is modified by interaction of host’s hormonal status and genotype: sex chromosomes X and Y, as well as autosomal genes. In this Mini Review we summarize the major influences of sex in human infections and subsequently focus on 22 autosomal genes/loci that modify in a sex-dependent way the response to infectious diseases in mouse models. These genes have been observed to influence susceptibility to viruses, bacteria, parasites, fungi and worms. Some sex-dependent genes/loci affect susceptibility only in females or only in males, affect both sexes, but have stronger effect in one sex; still other genes were shown to affect the disease in both sexes, but with opposite direction of effect in females and males. The understanding of mechanisms of sex-dependent differences in the course of infectious diseases may be relevant for their personalized management.

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Section: Introductionmentioning

confidence: 99%

Gene-Specific Sex Effects on Susceptibility to Infectious Diseases

Lipoldová

Démant

2021

Front. Immunol.

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“…Differences between females and males in PHA response may occur in different stages of the annual cycle, either during breeding or non-breeding period 76 . We did not have information on the breeding status of our sampled pigeons, but the species is considered to breed almost year-round, with a reproductive peak in spring and summer 77 , 78 .…”

Section: Discussionmentioning

confidence: 99%

Population density mediates induced immune response, but not physiological condition in a well-adapted urban bird

Kamiński

Chyb

Minias

2022

Sci Rep

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Thriving under high population density is considered a major feature of urban exploiter species. Nevertheless, population density appears to be a surprisingly overlooked factor in urban ecology studies. High population numbers observed in urban species might promote pathogen transmission and negatively affect health or condition, thus requiring investments in immunocompetence. The feral pigeon Columba livia domestica is an example of a successful city-dweller, found in great abundance in large cities across the globe. We investigated the effects of population density on induced immune response (phytohaemagglutinin skin test) and body condition (blood haemoglobin concentration and size-corrected body mass) in 120 feral pigeons, captured along population density gradient in Łódź (central Poland). We found that stronger immune response was associated with higher population density, but was not related to physiological condition and physiological stress (heterophil/lymphocyte ratio). Moreover, condition indices were not associated with population density. However, since pigeon population density was highly correlated with the level of habitat urbanization, we cannot exclude that any density-dependent effects may be mediated by habitat variation. Our results indicate that urban environment, via population density, might exert different selective pressures on immunocompetence and body condition in this successful urban exploiter.

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“…Los heterófilos y los linfocitos son leucocitos predominantes asociados a estresores, infecciones, inflamación o toxicidad (Davis et al, 2008;Jones, 2015). El comportamiento dominante de la especie puede mantenerlo en estrés constante y determinar sus niveles en la relación H:L (Valdebenito et al, 2021). Las diferencias entre los cuidados, alimentación, desparasitación de cada especie pueden modificar sus parámetros hematológicos (Campbell, 2015;Lashev et al, 2015).…”

Section: Diferencial De Leucocitosunclassified

Variables hematológicas en aves deportivas, ganso común, pato doméstico, pato azteca, guajolote y pollo de engorda

Sánchez-Torres¹,

Arredondo-Castro²,

Orozco-Benítez³

et al. 2021

Abanico Agrof.

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El análisis sanguíneo en aves es una evidencia que permite evaluar su estado de salud y es una herramienta diagnóstica para el médico veterinario clínico. El objetivo de la investigación fue conocer las variables hematológicas de aves comunes, deportivas, ganso común, pato doméstico, pato azteca, guajolote y pollo de engorda por sexo, especie y la diferencia entre las especies. Se tomó una muestra de sangre a 88 aves por venopunción de la vena ulnar usando ácido etilendiaminotetraacético (EDTA) como anticoagulante. Se contaron los eritrocitos y los leucocitos totales por el método de Natt y Herriks. El diferencial de leucocitos se realizó por medio de un frotis sanguíneo, se midió la concentración de hemoglobina con la técnica de cianometahemoglobina y el porcentaje de microhematocrito. Los datos fueron comparados con un análisis de varianza en un diseño completamente al azar y las diferencias se compararon con la prueba de Tukey (P<0.05). Para eosinófilos y basófilos se utilizó la prueba de Kruskal-Wallis debido a que los datos no presentaron normalidad. Las variables hematológicas en aves deportivas, ganso común, pato doméstico, pato azteca, guajolote y pollo de engorda fueron similares para hembras y machos de la misma especie. Pero hubo diferencias en células blancas de las especies estudiadas.

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Seasonal variation in sex-specific immunity in wild birds

Cited by 36 publications

References 92 publications

Gene-Specific Sex Effects on Susceptibility to Infectious Diseases

Gene-Specific Sex Effects on Susceptibility to Infectious Diseases

Population density mediates induced immune response, but not physiological condition in a well-adapted urban bird

Variables hematológicas en aves deportivas, ganso común, pato doméstico, pato azteca, guajolote y pollo de engorda

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