Seasonal Variation in Serum Lipid Levels in Japanese Workers

Kamezaki, Fumihiko; Sonoda, Shinjo; Tomotsune, Yusuke; Yunaka, Hiromi

doi:10.5551/jat.3566

Cited by 25 publications

(15 citation statements)

References 23 publications

(18 reference statements)

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“…The question has thus arisen as to why cholesterol levels have been found to be correlated with suicide attempts in some studies and not in others. Race differences in serum lipid profiles and lipoprotein lipase activity may be a culprit [15]; nutritional habits, life style, traditions, as well as seasons and climate may play a role in explaining these differences [10, 18, 19]. …”

Section: Resultsmentioning

confidence: 99%

The association between altered lipid profile and suicide attempt among Tunisian patients with schizophrenia

et al. 2016

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BackgroundThere have been many studies on psychiatric disorders, but very little is known about the biology of suicide with schizophrenia. In the present study, we are looking for a possible connection between altered lipid profile and suicidal behavior in schizophrenic Tunisian patients.MethodsAssay of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and triglycerides (TG) has been done for 126 schizophrenic patients with and without suicide attempts and 131 healthy controls recruited in the University Hospital of Monastir.ResultsTC and LDL-c levels were significantly higher in schizophrenic patients compared to controls. TC was significantly lower in schizophrenic patients with suicide attempt compared to those without suicide attempt. Depending to the sonority of suicide attempt, TC was significantly lower in patients with recent suicide attempt compared to those with lifetime suicide attempt and without suicide attempt (p < 0.001), and no significant differences between TG, LDL-c, and HDL-c were noted.ConclusionsResults of this study showed that TC levels in schizophrenic patients after a recent suicide attempt are significantly lower than in patients without suicide attempt and with lifetime suicide attempts. TC can be one of biological markers defined suicidal risk for schizophrenic patients.

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Section: Resultsmentioning

confidence: 99%

The association between altered lipid profile and suicide attempt among Tunisian patients with schizophrenia

et al. 2016

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“…In Japan, several diseases show seasonal variation. For example, myocardial infarction (9) and stroke (10) are more frequent in the winter than in the summer, while blood pressure (11), cholesterol (12), and hemoglobin A 1 C [HbA1C (13)] levels are all higher in the winter compared to in the summer. However, little is known about the seasonal variation of severe hypoglycemia.…”

Section: Introductionmentioning

confidence: 99%

Seasonal Variation of Severe Hypoglycemia in Hospitalized Patients 60 years of Age or Older Presenting to an Emergency Center Hospital between 2004 and 2010

et al. 2013

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Objective To investigate the seasonal variation of severe hypoglycemia in hospitalized elderly patients. Methods Among the patients hospitalized in our department between 2004 and 2010, we analyzed the records of 67 patients who required emergency admission for severe hypoglycemia and were aged 60 years or older. Comparisons were made between those admitted during the warm season (April-September) and those in the cold season (October-March). Patients The mean age of the 67 patients was 76±8 years, including 45 men and 22 women. Twenty-four patients were admitted in the warm season and 43 patients were admitted in the cold season, with the average annual number being 3.4±1.9 and 6.1±2.8, respectively (p<0.05). Results Admissions for patients taking insulin showed no significant difference between the warm and cold season. In contrast, significantly fewer patients taking oral hypoglycemic agents were admitted in the warm season than in the cold season (5 vs. 22, p<0.05). Among them, 26 patients (96%) were taking sulfonylurea, and anorexia associated with acute infections was the main cause of severe hypoglycemia. In the warm season, all of the patients were discharged without complications, while 8 patients had complications in the cold season. Conclusion A seasonal variation regarding hospitalization was observed for severe hypoglycemia among the patients 60 years of age or older, with a higher incidence in the cold season than the warm season, and anorexia related to infections in patients taking sulfonylureas was responsible for this variation. Accordingly, careful management of acute illness is needed for patients using sulfonylureas, especially during the cold season.

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“…4,5 Evidence suggests that these metabolic parameters can show seasonal variations, and these variations usually tend to be on the higher end during the fall and winter than in the spring and summer. [6][7][8][9][10] Seasonal variations in these metabolic parameters could be partially driven by gene variation, lifestyle factors such as diet, physical activity and sleep duration, climate conditions such as air temperature and light exposure, and mood changes such as depressive symptoms. [11][12][13][14][15][16][17][18] These findings indicate that seasonal variations in metabolic parameters may affect the assessment of MetS.…”

Section: Introductionmentioning

confidence: 99%

Association of seasonal variation in the prevalence of metabolic syndrome with insulin resistance

et al. 2012

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The aim of this study was to examine the hypothesis that seasonal variation in the prevalence of metabolic syndrome (MetS) is associated with increased insulin resistance. Among 840 Japanese male workers who were evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR) in June (summer) 2010, we prospectively studied a total of 758 subjects (40-65 years of age) who underwent an assessment in December (winter) 2010. MetS was defined according to the criteria proposed by the International Diabetes Federation (IDF) and the Japanese Society of Internal Medicine (JSIM). The median level of HOMA-IR in the study subjects was 0.84 (interquartile range: 0.60-1.19). The prevalence rates of IDF- and JSIM-MetS significantly increased from 12.4 and 9.6% in the summer to 16.6 and 13.3% in the winter, respectively (each P<0.05). Our data suggest that these increases are mainly due to increases in blood pressure (BP) and glucose during the winter assessment. The prevalence rates of IDF-MetS in the first, second, third and fourth quartiles of HOMA-IR were 1.1, 5.8, 14.3 and 29.1% in the summer and 3.1, 10.6, 21.9, and 31.3% in the winter, respectively. Similar results were obtained when using the JSIM criteria. In the third quartile, the frequency of elevated BP increased from 42.4% in the summer to 61.2% in the winter (P<0.05), and these values were mainly correlated with significant variations in IDF- and JSIM-MetS prevalence rates. This study demonstrates that seasonal variation in MetS prevalence is associated with mildly to moderately increased insulin resistance in middle-aged Japanese men.

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Seasonal Variation in Serum Lipid Levels in Japanese Workers

Abstract: Aim: Seasonal variation in serum lipid levels in the Japanese population remains unclear. The aim of this study was to determine whether a variation in lipid levels exists in Japanese workers.

Cited by 25 publications

References 23 publications

The association between altered lipid profile and suicide attempt among Tunisian patients with schizophrenia

The association between altered lipid profile and suicide attempt among Tunisian patients with schizophrenia

Seasonal Variation of Severe Hypoglycemia in Hospitalized Patients 60 years of Age or Older Presenting to an Emergency Center Hospital between 2004 and 2010

Association of seasonal variation in the prevalence of metabolic syndrome with insulin resistance

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