Seasonal Variation and Analgesic Properties of Different Parts from Curcuma zedoaria Roscoe (Zingiberaceae) Grown in Brazil

Abstract

This work describes the seasonal variation of curcumenol (1) and dihydrocurdione (2), two active terpenoids from different parts (roots, mother rhizome and rugous rhizome) of Curcuma zedoaria grown in Brazil. The analysis was carried out by high resolution gas chromatography, using external standards for determination. The results showed that both terpenoids are present in all the parts studied. However, C. zedoaria exhibited about three times more terpenoids in the mother rhizome in autumn than in other parts and seasons studied. The antinociceptive activity of the dichloromethane extracts from different parts and collected in different seasons was studied using the acetic acid-induced abdominal constriction model in mice. The extracts obtained from mother rhizome collected in autumn and winter at doses of 10 mg/kg body weight, i.p., caused considerable antinociceptive activity inhibiting 91.1 and 93.4% of the abdominal constrictions, respectively, whereas compounds 1 and 2 caused inhibitions of 64.0 and 46.0%, respectively. These results confirm that both compounds contribute to explain the antinociceptive effect of the plant but suggest that other compounds are also acting as analgesics

Effect of different ingredients in traditional Korean medicine for human uterine leiomyoma on normal myometrial and leiomyomal smooth muscle cell proliferation

“…L. sibiricus displays analgesic and anti-inflammatory activities (Islam et al, 2005), moderate cytotoxic activity against leukemia cells (Satoh et al, 2003), and inhibits uterine adenomyosis (Nagasawa et al, 1990). C. zedoaria has been reported to act as an analgesics and an anti-inflammatory agent (Yoshioka, 1998;Pamplona et al, 2006). In addition to the effect on cell proliferation after traditional medicine treatment, cell morphological changes were also presently observed coincident with the application of treatment ingredients, indicating the positive effect of treatment on normal myometrium and leiomyoma.…”

Effect of developmental stage on total phenolics composition and anti-oxidant activities inHedychium spicatumBuch.-Ham. ex. D. Don.

“…For example, curcumenol and dihydrocurdione concentrations were four-to-five-times higher in Spring than in Autumn in the rhizomes of Curcuma zedoaria (Pamplona et al, 2006). Likewise, the concentrations of flavonoids such as hypericin and pseudohyperisin varied in H. perforatum over different seasons (Southwell and Bourke, 2001).…”

Cytotoxicity of the rhizome of medicinal plants

“…Ampicillin trihydrate was used as positive control and DMSO used as negative control. After hatching and maturation of A. salina Leach, 10 larvae were placed in each vials using a Pastuer pipette and incubated at (25)(26)(27) 曟 for 24 h under illumination.…”

“…The rhizome of C. zedoaria Rosc. has been reported to have antimicrobial [24] , antinociceptive [25] , hepatoprotective [26] and antioxidant [2] activities. The present study was undertaken to investigate the cytotoxic effect of Z. zerumbet (L) Smith.…”