Seasonal Variation and Age‐Related Changes in Human Semen Parameters

Chen, Zuying; Toth, Thomas L.; Godfrey‐Bailey, Linda; Mercedat, Nelta; Schiff, Isaac; Hauser, Russ

doi:10.1002/j.1939-4640.2003.tb02666.x

Cited by 113 publications

(81 citation statements)

References 20 publications

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“…However, in an earlier study they found inverse associations between age and sperm concentration, motility and morphology. They attributed those findings to an older population of males compared to their earlier study (63). Also, age was significantly positively correlated with the studied apoptotic markers.…”

Section: Discussionmentioning

confidence: 57%

Apoptotic markers in semen of infertile men: association with cigarette smoking

El-Melegy

Ali

2011

Int. braz j urol.

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Objectives: (i) To examine the role of apoptosis in the pathogenesis of DNA damage in semen from infertile men. (ii) To assess the effects of smoking on apoptotic markers and seminal parameters among infertile men. (iii) To assess the correlation of apoptosis with conventional semen parameters. Materials and Methods:The study was carried out on 70 men with idiopathic infertility, divided into two groups: thirty infertile non smokers and forty infertile smokers. In addition to 60 fertile men (30 non smokers and 30 smokers) as control group. Each subject provided semen for analysis of parameters, determination of % of DNA fragmentation, s-Fas, caspase-3 activity levels and cotinine levels. Results:The results revealed that infertile men, particularly smokers have significantly lower semen variables and significantly higher levels of apoptotic variables (% of DNA fragmentation, s-Fas and caspase-3 activity) in addition to cotinine. Conclusions:The present findings provide additional evidence supporting the importance of the evaluation of apoptotic markers to test male infertility particularly among smokers.

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Section: Discussionmentioning

confidence: 57%

Apoptotic markers in semen of infertile men: association with cigarette smoking

El-Melegy

Ali

2011

Int. braz j urol.

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“…On the reproductive health side, prior work suggests that exposure to extreme heat negatively affects semen quality and testosterone levels (Levine, 1991;Dada et al, 2001;Chen et al, 2003;Svartberg et al, 2003), and interferes with menstruation, ovulation, and implantation (Meade and Earickson, 2000;Ellison et al, 2005).…”

Section: IImentioning

confidence: 99%

Maybe Next Month? Temperature Shocks, Climate Change, and Dynamic Adjustments in Birth Rates

2015

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Standard-Nutzungsbedingungen:Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden.Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen.Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesen Nutzungsbedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. Dynamic adjustments could be a useful strategy for mitigating the costs of acute environmental shocks when timing is not a strictly binding constraint. To investigate whether such adjustments could apply to fertility, we estimate the effects of temperature shocks on birth rates in the United States between 1931 and 2010. Our innovative approach allows for presumably random variation in the distribution of daily temperatures to affect birth rates up to 24 months into the future. We find that additional days above 80 °F cause a large decline in birth rates approximately 8 to 10 months later. The initial decline is followed by a partial rebound in births over the next few months implying that populations can mitigate the fertility cost of temperature shocks by shifting conception month. This dynamic adjustment helps explain the observed decline in birth rates during the spring and subsequent increase during the summer. The lack of a full rebound suggests that increased temperatures due to climate change may reduce population growth rates in the coming century. As an added cost, climate change will shift even more births to the summer months when third trimester exposure to dangerously high temperatures increases. Based on our analysis of historical changes in the temperature-fertility relationship, we conclude air conditioning could be used to substantially offset the fertility costs of climate change. Terms of use: Documents in D I S C U S S I O N P A P E R S E R I EJEL Classification: I12, J13, Q54

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“…Further, the semen quality of Japanese fertile men is similar to Danish men, which has lowest values among the European males [24]. Meanwhile, a number of studies indicate the association of increased age with decline in the semen characteristics [31][32][33][34] whereas, a few reports showed no such association [35][36]. Altogether, there is a possibility that combination of genetic and environmental factors including nutritional, geographical, life style, and their interactions accounts for variations observed in the semen parameters that are studied across different populations.…”

Section: Introductionmentioning

confidence: 95%

A Comprehensive and Systematic Study of Semen Quality and Sperm Functional Status in Normozoospermic Controls and Infertile Males from South India

Hs¹,

Sreenivasa²

2015

Andrology (Los Angel)

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Objective: Despite, several global studies indicate the variations in semen characteristics that accounts for male infertility, the association of specific changes in semen quality and fertility status among different Indian communities are poorly investigated. With wide range of geographical locations, diverse lifestyle patterns, seasonal variations combined with heterogeneous population, India offers an excellent system to study genotype-to-phenotype correlation. Hence, the current study has been initiated in South Karnataka region of India, in order to examine the variations in semen quality and sperm functional status in infertile individuals compared with normozoospermic controls.Methods: WHO strict guidelines are followed for systematic semen analysis of 239 infertile and 244 normozoospermic control subjects.Results: Interestingly, compared to normozoospermic controls, higher percentage of physical abnormalities such as, low semen volume and reduced sperm count are observed in infertile men. Additionally, semen characteristics namely, vitality and motility values are significantly reduced in infertile than controls. Further, in sperm function test the lower scores are documented for hypo-osmotic swelling assay, but not for sperm chromatin decondensation and acrosome intactness examination, suggesting loss of sperm plasma membrane integrity in infertile men. Moreover, the observed changes in semen parameters and sperm function are also evident in different infertile sub-conditions with varied responses. Surprisingly, age wise analysis revealed reduction in sperm morphology scores, whereas, vitality, count, motility and volume remain unchanged with increasing age of infertile males. However, we recorded inverse relationship between age and sperm vitality as well as motility in normozoospermic control men. Together, though the scores for different semen parameters in normozoospermic control group are in accordance with WHO reference range, the infertile men displayed poor semen quality. Conclusion:Thus, our data establishes basic differences between infertile and normozoospermic control group in terms of semen characteristics and sperm functional status, but the cause may be attributable to genetic or environmental factors or interaction of the two, which necessitates further detailed examination in larger cohort among heterogeneous population.

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Seasonal Variation and Age‐Related Changes in Human Semen Parameters

Cited by 113 publications

References 20 publications

Apoptotic markers in semen of infertile men: association with cigarette smoking

Apoptotic markers in semen of infertile men: association with cigarette smoking

Maybe Next Month? Temperature Shocks, Climate Change, and Dynamic Adjustments in Birth Rates

A Comprehensive and Systematic Study of Semen Quality and Sperm Functional Status in Normozoospermic Controls and Infertile Males from South India

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