Seasonal variance in the chemical composition of essential oils from Lantana camaraaccessions and their trypanocidal activity on Phytomonas serpens

Pereira, Katily Luize Garcia; Nizio, Daniela Aparecida de Castro; Nogueira, Paulo César de Lima; Fernandes, Roberta Pereira Miranda; Arrigoni-Blank, Maria de Fátima; Filho, Jose Carlos Freitas de Sá; Nascimento, Luís Fernando de Andrade; Souza, Vinicius Trindade de; Silva, Kleiton Paulo; Blank, Arie Fitzgerald

doi:10.37360/blacpma.22.21.6.45

Cited by 3 publications

(3 citation statements)

References 34 publications

(41 reference statements)

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“…EOs from Varronia curassavica genotypes have antiprotozoal activity against Phytomonas serpens causing alterations in the permeabilization of the cytoplasmic membrane [ 33 ]. Lantana camara EOs, extracted at different harvesting times, displayed trypanocidal activity on P. serpens [ 34 ], and EOs from Hyssopus officinalis showed antiprotozoal activity on T. cruzi and P. davidi [ 35 ]. However, this is the first report on the phytomonacidal effects of the EOs studied here.…”

Section: Discussionmentioning

confidence: 99%

Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

et al. 2023

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Kinetoplastida is a group of flagellated protozoa characterized by the presence of a kinetoplast, a structure which is part of a large mitochondria and contains DNA. Parasites of this group include genera such as Leishmania, that cause disease in humans and animals, and Phytomonas, that are capable of infecting plants. Due to the lack of treatments, the low efficacy, or the high toxicity of the employed therapeutic agents there is a need to seek potential alternative treatments. In the present work, the antiparasitic activity on Leishmania infantum and Phytomonas davidi of 23 essential oils (EOs) from plants of the Lamiaceae and Asteraceae families, extracted by hydrodistillation (HD) at laboratory scale and steam distillation (SD) in a pilot plant, were evaluated. The chemical compositions of the EOs were determined by gas chromatography-mass spectrometry. Additionally, the cytotoxic activity on mammalian cells of the major components from the most active EOs was evaluated, and their anti-Phytomonas and anti-Leishmania effects analyzed. L. infantum was more sensitive to the EOs than P. davidi. The EOs with the best anti-kinetoplastid activity were S. montana, T. vulgaris, M. suaveolens, and L. luisieri. Steam distillation increased the linalyl acetate, β-caryophyllene, and trans-α-necrodyl acetate contents of the EOs, and decreased the amount of borneol and 1,8 cineol. The major active components of the EOs were tested, with thymol being the strongest anti-Phytomonas compound followed by carvacrol. Our study identified potential treatments against kinetoplastids.

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Section: Discussionmentioning

confidence: 99%

Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

et al. 2023

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“…The anti- P. serpens activity of natural products such as Varroniacuras savica and Lantana camara essential oils, as well as alkaloids including tomatine and tomatidine, have been reported [ 9 , 11 , 13 ]. Chalcones have been considered promising molecules due to their broad range of biological activities, multi-target action, simple chemistry and low toxicity [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Exploring natural products has been a good strategy to search for new candidates for the development of new drugs against protozoa, including trypanosomatids. The literature points out a wide variety of essential oils [ 8 , 9 ], plant extracts [ 10 , 11 ], and isolated compounds [ 12 , 13 , 14 ] that show anti-trypanosomatids activity. Among the main classes of active natural products are alkaloids, quinones, terpenes and phenolic compounds [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Chalcone Derivative Induces Flagellar Disruption and Autophagic Phenotype in Phytomonas serpens In Vitro

et al. 2023

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Phytomonas serpens is a trypanosomatid phytoparasite, found in a great variety of species, including tomato plants. It is a significant problem for agriculture, causing high economic loss. In order to reduce the vegetal infections, different strategies have been used. The biological activity of molecules obtained from natural sources has been widely investigated to treat trypanosomatids infections. Among these compounds, chalcones have been shown to have anti-parasitic and anti-inflammatory effects, being described as having a remarkable activity on trypanosomatids, especially in Leishmania species. Here, we evaluated the antiprotozoal activity of the chalcone derivative (NaF) on P. serpens promastigotes, while also assessing its mechanism of action. The results showed that treatment with the derivative NaF for 24 h promotes an important reduction in the parasite proliferation (IC50/24 h = 23.6 ± 4.6 µM). At IC50/24 h concentration, the compound induced an increase in reactive oxygen species (ROS) production and a shortening of the unique flagellum of the parasites. Electron microscopy evaluation reinforced the flagellar phenotype in treated promastigotes, and a dilated flagellar pocket was frequently observed. The treatment also promoted a prominent autophagic phenotype. An increased number of autophagosomes were detected, presenting different levels of cargo degradation, endoplasmic reticulum profiles surrounding different cellular structures, and the presence of concentric membranar structures inside the mitochondrion. Chalcone derivatives may present an opportunity to develop a treatment for the P. serpens infection, as they are easy to synthesize and are low in cost. In order to develop a new product, further studies are still necessary.

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Anti-Phytomonas activity of the lyophilized residues obtained from the distillation of Lantana camara L. essential oil

Soares,

de Carvalho Santos,

de Andrade Nascimento

et al. 2024

Environ Sci Pollut Res

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Seasonal variance in the chemical composition of essential oils from Lantana camaraaccessions and their trypanocidal activity on Phytomonas serpens

Cited by 3 publications

References 34 publications

Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

Chalcone Derivative Induces Flagellar Disruption and Autophagic Phenotype in Phytomonas serpens In Vitro

Anti-Phytomonas activity of the lyophilized residues obtained from the distillation of Lantana camara L. essential oil

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