Seasonal variability of oxidative biomarkers, lysosomal parameters, metallothioneins and peroxisomal enzymes in the Mediterranean mussel Mytilus galloprovincialis from Adriatic Sea

Bocchetti, Raffaella; Regoli, Francesco

doi:10.1016/j.chemosphere.2006.03.049

Cited by 201 publications

(113 citation statements)

References 41 publications

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“…higher seawater temperature, solar irra--diance, oxygen decrease) that could induce higher physiological stress as already observed for other bivalve species (Andrès et al, 1999;Baudrimont et al, 1997;Bocchetti and Regoli, 2006;Bocchetti et al, 2008;Leiniö and Lehtonen, 2005). Additionally, oxidative damage such as lipid peroxidation or DNA damage can be triggered and produce detrimental effects on the physiological status of clams (Bocchetti and Regoli, 2006;Bocchetti et al, 2008;Sobral and Widdows, 1997). The PCA for the overall data (Fig.…”

Section: Biomarkers Indicesmentioning

confidence: 78%

“…A very important aspect related to the use of a multibiomarker approach in risk assessment is the need of having a detailed knowledge of basal biomarkers response and of its seasonal vari--ation to distinguish pollution induced effects from those induced by the natural biological cycle of clams, including the reproductive cycle and spawning period (Bocchetti and Regoli, 2006;Bocchetti et al, 2008). A CI decreasing pattern was detected in summer months (Table 5), particularly from August to November, which may be due to loss of weight/body mass associated with the period of spawning (accentuated in August and September for this species).…”

Section: Biomarkers Indicesmentioning

confidence: 99%

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A multibiomarker approach in the clam Ruditapes decussatus to assess the impact of pollution in the Ria Formosa lagoon, South Coast of Portugal

Cravo

Pereira

Gomes

et al. 2012

Marine Environmental Research

104

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Section: Biomarkers Indicesmentioning

confidence: 78%

Section: Biomarkers Indicesmentioning

confidence: 99%

A multibiomarker approach in the clam Ruditapes decussatus to assess the impact of pollution in the Ria Formosa lagoon, South Coast of Portugal

Cravo

Pereira

Gomes

et al. 2012

Marine Environmental Research

104

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…CAT mainly exists in the peroxisomes of aerobic cells and serves to protect against damage from hydrogen peroxide by catalyzing it into molecular oxygen and water without producing toxic free radicals (Bocchetti and Regoli, 2006;Yilmaz et al, 2006). The metalloenzyme, SOD, can convert two molecules of superoxide, produced during the oxidative stress, to hydrogen peroxide (Bocchetti and Regoli, 2006). There are three SOD isoenzymes in mammalian cells: CuZn-SOD (copper-and zinc-containing SOD, mainly cytosolic), Mn SOD (manganese-containing SOD, located in the mitochondria), and EC SOD (extracellular SOD, actually also CuZn-SOD) (Zelko et al, 2002); of these, CuZn-SOD is probably the most important anti-oxidant enzyme (Peskin, 1997).…”

Section: Discussionmentioning

confidence: 99%

Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo

Wang

Sheng

et al. 2014

J. Zhejiang Univ. Sci. B

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Abstract:The present study is designed to investigate the protection by ferulic acid against the hepatotoxicity induced by diosbulbin B and its possible mechanism, and further observe whether ferulic acid augments diosbulbin Binduced anti-tumor activity. The results show that ferulic acid decreases diosbulbin B-increased serum alanine transaminase/aspartate transaminase (ALT/AST) levels. Ferulic acid also decreases lipid peroxide (LPO) levels which are elevated in diosbulbin B-treated mice. Histological evaluation of the liver demonstrates hydropic degeneration in diosbulbin B-treated mice, while ferulic acid reverses this injury. Moreover, the activities of copper-and zinc-containing superoxide dismutase (CuZn-SOD) and catalase (CAT) are decreased in the livers of diosbulbin B-treated mice, while ferulic acid reverses these decreases. Further results demonstrate that the mRNA expressions of CuZn-SOD and CAT in diosbulbin B-treated mouse liver are significantly decreased, while ferulic acid prevents this decrease. In addition, ferulic acid also augments diosbulbin B-induced tumor growth inhibition compared with diosbulbin B alone. Taken together, the present study shows that ferulic acid prevents diosbulbin B-induced liver injury via ameliorating diosbulbin B-induced liver oxidative stress injury and augments diosbulbin B-induced anti-tumor activity.

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“…32 The increase in these enzyme activities suggests a response toward increased ROS generation. 33,34 Moreover, it is reported that Cr(VI) often generates free radicals, which in turn activate O 2 and produce ROS, including hydroxyl radicals, singlet oxygen, superoxide and hydrogen peroxide, 23,35 and consequently lead to DNA damage.…”

mentioning

confidence: 99%

The prospective protective effect of selenium nanoparticles against chromium-induced oxidative and cellular damage in rat thyroid

Hassanin¹,

El-Kawi²,

Hashem³

2013

IJN

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Background: Nanotechnology has enabled researchers to synthesize nanosize particles that possess increased surface areas. Compared to conventional microparticles, it has resulted in increased interactions with biological targets. Objective: The objective of this study was to determine the protective ability of selenium nanoparticles against hexavalent chromium-induced thyrotoxicity. Design: Twenty male rats were used in the study, and arbitrarily assigned to four groups. Group 1 was the control group, and was given phosphate-buffered saline. Group 2 was the chromium-treated group and was given K 2 Cr 2 O 7 60 µg/kg body weight intraperitoneally as a single dose on the third day of administration. Group 3 was the nano-selenium-treated group and was given selenium nanoparticles (size 3-20 nm) 0.5 mg/kg body weight intraperitoneally daily for 5 consecutive days. Group 4 was the nano-selenium chromium-treated group, which received selenium nanoparticles for 5 days and a single dose of K 2 Cr 2 O 7 on the third day of administration. Materials and methods: Blood samples were collected from rats for measuring thyroid hormones (free triiodothyronine [T 3 ] and free thyroxine [T 4 ]) and oxidative and antioxidant parameters (malondialdehyde [MDA], reduced glutathione [GSH], catalase, and superoxide dismutase [SOD]). Upon dissection, thyroid glands were taken for histopathological examination by using paraffin preparations stained with hematoxylin and eosin (H&E) and Masson's trichrome. Immunohistochemical staining was performed for detecting cellular proliferation using Ki67 antibodies.Results: The present study shows that K 2 Cr 2 O 7 has a toxic effect on the thyroid gland as a result of inducing a marked oxidative damage and release of reactive oxygen species. This was shown by the significant decrease in free T 3 and T 4 and GSH levels, which was accompanied by significant increases in catalase, SOD, and MDA in the chromium-treated group compared to the control group. Se nanoparticles have a protective effect on K 2 Cr 2 O 7 -induced thyroid damage, as a result of correcting the free T 3 and T 4 levels and GSH, catalase, SOD, and MDA compared to the K 2 Cr 2 O 7 -treated group. Administration of nano-selenium alone in the nano-selenium-treated group had no toxic effect on rats' thyroid compared to the control group. The biochemical results were confirmed by histopathological, immunohistochemical and pathomorphological studies.

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Seasonal variability of oxidative biomarkers, lysosomal parameters, metallothioneins and peroxisomal enzymes in the Mediterranean mussel Mytilus galloprovincialis from Adriatic Sea

Cited by 201 publications

References 41 publications

A multibiomarker approach in the clam Ruditapes decussatus to assess the impact of pollution in the Ria Formosa lagoon, South Coast of Portugal

A multibiomarker approach in the clam Ruditapes decussatus to assess the impact of pollution in the Ria Formosa lagoon, South Coast of Portugal

Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo

The prospective protective effect of selenium nanoparticles against chromium-induced oxidative and cellular damage in rat thyroid

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