Seasonal variability does not impact in vitro fertilization success

Liu, Xitong; Bai, Haiyan; Mol, Ben W.; Shi, Wenhao; Gao, Ming; Shi, Juanzi

doi:10.1038/s41598-019-53919-3

Cited by 18 publications

(19 citation statements)

References 16 publications

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“…Because of the Covid-19 pandemic, we were constrained to suspend transfers between March and June 2020. We compared two similar periods between the two years to avoid a potential seasonality bias, even though no significant difference of seasonal variations in the outcomes of IVF was observed in the literature [ 70 , 71 ]. A pending question concerned pregnancies after double embryo transfers, where a 50% agreement was found.…”

Section: Discussionmentioning

confidence: 99%

Change in the Strategy of Embryo Selection with Time-Lapse System Implementation—Impact on Clinical Pregnancy Rates

Boucret

Tramon

Saulnier

et al. 2021

JCM

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Time-lapse systems (TLS) and associated algorithms are interesting tools to improve embryo selection. This study aimed to evaluate how TLS and KIDScore™ algorithm changed our practices of embryo selection, as compared to a conventional morphological evaluation, and improved clinical pregnancy rates (CPR). In the study group (year 2020, n = 303 transfers), embryos were cultured in an EmbryoScope+ time-lapse incubator. A first team observed embryos conventionally once a day, while a second team selected the embryos for transfer based on time-lapse recordings. In the control group (year 2019, n = 279 transfers), embryos were selected using the conventional method, and CPR were recorded. In 2020, disagreement between TLS and the conventional method occurred in 32.1% of transfers, more often for early embryos (34.7%) than for blastocysts (20.5%). Irregular morphokinetic events (direct or reverse cleavage, multinucleation, abnormal pronuclei) were detected in 54.9% of the discordant embryos. When it was available, KIDScore™ was decreased for 73.2% of the deselected embryos. Discordant blastocysts mainly corresponded with a decrease in KIDScore™ (90.9%), whereas discordant Day 3 embryos resulted from a decreased KIDScore™ and/or an irregular morphokinetic event. CPR was significantly improved in the TLS group (2020), as compared to the conventional group (2019) (32.3% vs. 21.9%, p = 0.005), even after multivariate analysis. In conclusion, TLS is useful to highlight some embryo development abnormalities and identify embryos with the highest potential for pregnancy.

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Section: Discussionmentioning

confidence: 99%

Change in the Strategy of Embryo Selection with Time-Lapse System Implementation—Impact on Clinical Pregnancy Rates

Boucret

Tramon

Saulnier

et al. 2021

JCM

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“…Possible limitation of our study is the fact, that AMH is a stable prognostic marker for the amount of oocytes that might be retrieved after stimulation in an IVF/ICSI cycle, but it is a poor marker for predicting a pregnancy [43], as it is only weakly associated with embryo implantation [17]. The majority of studies suggested no statistically association between clinical pregnancy rates or life birth rates [1,4,6,30,34,44], probably due to speci c framework of the studies. However, Brodin et al showed a strong association between AMH and live birth rates after ART [45].These ndings may indicate a relation between AMH, vitamin D and oocyte quality.…”

Section: Discussionmentioning

confidence: 85%

Seasonal Dynamic of Cholecalciferol (D3) And Anti-Muellerian Hormone (AMH) With Impact On Ovarian Response And IVF/ICSI

Rogenhofer¹,

Jeschke²,

Schönfeldt³

et al. 2021

Preprint

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Objective:Recent studies revealed intriguing associations between cholecalciferol (D3) and reproductive functions. Seasonal changes of D3 concentrations are well known, however they are not always considered in the context of reproductive functions. In this study, we analysed D3 serum concentration in IVF/ICSI patients with respect to seasonal 3-month quartiles and anti-Muellerian hormone (AMH) referring to the impact on Assisted Reproductive Technologies (ART) outcome. Materials and Research Methods:We studied 497 female patients, presenting between 2012 and 2018 for ART treatment in our fertility center. D3 as well as the AMH serum concentrations were measured at the beginning of the follicle stimulation (d 3-5 of menstrual cycles). Results were evaluated with respect to seasonal quartiles and outcome of the ART cycles. Results:D3 concentrations showed significant fluctuations within annual quartiles with a pronounced peak in August-October and a minimum in February-April (27.7mg/dl vs. 20.9mg/dl; p<0.0001). Similar seasonal dynamics were found for AMH (3.19ng/ml vs. 2.24ng/ml; p=0.013) and these were associated with significantly shorter stimulation periods during August-October (11.36d vs. 12.01d; p=0.044), higher number of fertilized oocytes between August-October (6.21 vs. 5.21; p=0.05) along with a trend towards higher numbers of Cumulus-Oocyte-complexes. However, no such differences were found for the numbers of MII-oocytes or pregnancy rates.Conclusion: Our data indicate, seasonal 3-month quartile variations of AMH concentrations and characteristics of ART, such as days of ovarian stimulation and number of fertilised oocytes. Highest AMH concentrations were found between August and October and this quartile was associated with highest D3 concentrations.

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“…A large retrospective cohort study conducted in China included 38,476 women who underwent either fresh or frozen embryo transfer. [ 21 ] The study groups were divided into 3 monthly groups into spring, summer, autumn, and winter. The unadjusted model showed a significant difference in clinical pregnancy rates ( P = 0.027) and embryo cleavage rate ( P = 0.033) with significantly higher rates in summer.…”

Section: Discussionmentioning

confidence: 99%

“…[ 17 18 ] In addition, some investigators further reported no significant difference in fertilization, clinical pregnancy, or LBRs following ART in different seasons. [ 19 20 21 ] The lack of consistency in the results may be attributed to the heterogeneity in study population, ART protocols, ethnicity, and regional variations in types and duration of seasons.…”

Section: Introductionmentioning

confidence: 99%

“…It is important to note that most of the studies are reported in European[ 17 18 19 ] and Middle eastern[ 15 20 ] population as well as a study from China. [ 21 ] There are no published studies on effects of seasonal variations on ART outcomes from South Asia. Considering the wide variation in seasons experienced in different countries, there is a need for studies from Asia and Australia.…”

Section: Introductionmentioning

confidence: 99%

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Seasonal influence on assisted reproductive technology outcomes: A retrospective analysis of 1409 cycles

et al. 2021

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Background: It is well known that seasonal variations influence natural conception and birth rates variably in different populations. It has been hypothesised that similar seasonal influences may affect treatment outcomes following assisted reproductive technology (ART). However, most studies report conflicting results. Aim: The aim of the study is to elucidate whether seasonality had any impact on the treatment success of the ART program. Study Setting and Design: We conducted a retrospective cohort study at a university-level tertiary care hospital in South India. Materials and Methods: All couples who underwent ART between January 2012 and December 2016 were included in the study. We divided the study population into three groups based on the seasonal differences experienced in our region. The primary outcome was live birth rate (LBR). Statistical Analysis: Univariate and multiple logistic regression models were used to compare outcomes and results reported as odds ratio (OR) and 95% confidence interval (CI). Results: Univariate analysis revealed no significant difference in LBR in monsoon season (174/651, 26.7% vs. 83/319, 26.0%; OR 1.04, 95% CI 0.77,1.41; P = 0.81) as compared to summer. However, LBR was significantly higher in winter season (114/341, 33.4% vs. 83/319, 26.0%; OR 1.43; 95% CI: 1.02, 2.00; P = 0.04). Further, multivariate analysis following adjustment for various confounding factors revealed no significant statistical difference in LBR in monsoon (adjusted odds ratio [aOR], 0.92; 95% CI: 0.66, 1.26; P = 0.59) or winter (aOR 1.32; 95% CI: 0.92, 1.88; P = 0.13) as compared to summer season. Conclusion: The current study found no significant effect of seasonal variation on LBR following ART.

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Seasonal variability does not impact in vitro fertilization success

Cited by 18 publications

References 16 publications

Change in the Strategy of Embryo Selection with Time-Lapse System Implementation—Impact on Clinical Pregnancy Rates

Change in the Strategy of Embryo Selection with Time-Lapse System Implementation—Impact on Clinical Pregnancy Rates

Seasonal Dynamic of Cholecalciferol (D3) And Anti-Muellerian Hormone (AMH) With Impact On Ovarian Response And IVF/ICSI

Seasonal influence on assisted reproductive technology outcomes: A retrospective analysis of 1409 cycles

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