Seasonal rhythms of vasopressin release and aquaporin-2 excretion assure appropriate water conservation in humans

Goswami, Nandu; Mise, Annarita Di; Centrone, Mariangela; Russo, Annamaria; Ranieri, Marianna; Reichmuth, Johann; Brix, Bianca; Santo, Natale G. De; Sasso, Ferdinando Carlo; Tamma, Grazia; Valenti, Giovanna

doi:10.1186/s12967-021-02856-9

Cited by 5 publications

(3 citation statements)

References 10 publications

(7 reference statements)

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“…The seasonal variation of VP has been largely unexplored. Two small previous studies investigated seasonal variation of VP in young, healthy volunteers in a temperate climate (Japan and Austria) [13,22]. In contrast to our current study, these studies found a higher VP in the warm season than during the cold season.…”

Section: Discussioncontrasting

confidence: 99%

Seasonal variation of vasopressin and its relevance for the winter peak of cardiometabolic disease: A pooled analysis of five cohorts

et al. 2022

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Background Vasopressin concentration is typically higher at night, during stress, and in males, but readily lowered by water intake. Vasopressin is also a causal candidate for cardiometabolic disease, which shows seasonal variation. Objective To study whether vasopressin concentration varies by season in a temperate climate. Methods The vasopressin surrogate marker copeptin was analyzed in fasting plasma samples from five population‐based cohorts in Malmö, Sweden (n = 25,907, 50.4% women, age 18–86 years). We investigated seasonal variation of copeptin concentration and adjusted for confounders in sinusoidal models. Results The predicted median copeptin level was 5.81 pmol/L (7.18 pmol/L for men and 4.44 pmol/L for women). Copeptin exhibited a distinct seasonal pattern with a peak in winter (mid‐February to mid‐March) and nadir in late summer (mid‐August to mid‐September). The adjusted absolute seasonal variation in median copeptin was 0.62 pmol/L (95% confidence interval [CI] 0.50; 0.74, 0.98 pmol/L [95% CI 0.73; 1.23] for men and 0.46 pmol/L [95% CI 0.33; 0.59] for women). The adjusted relative seasonal variation in mean log copeptin z‐score was 0.20 (95% CI 0.17; 0.24, 0.18 [95% CI 0.14; 0.23] in men and 0.24 [95% CI 0.19; 0.29] in women). The observed seasonal variation of copeptin corresponded to a risk increase of 4% for incident diabetes mellitus and 2% for incident coronary artery disease. Conclusion The seasonal variation of the vasopressin marker copeptin corresponds to increased disease risk and mirrors the known variation in cardiometabolic status across the year. Moderately increased water intake might mitigate the winter peak of cardiometabolic disease.

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Section: Discussioncontrasting

confidence: 99%

Seasonal variation of vasopressin and its relevance for the winter peak of cardiometabolic disease: A pooled analysis of five cohorts

et al. 2022

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“…A non-j-shaped increase in copeptin concentration with increased temperature resembles the conventional understanding of the vasopressin system and is congruent to past findings from smaller studies showing higher vasopressin concentration during warm compared to cold season. 24 , 25 Our current results may thus facilitate the merging of our previous finding of a seasonal effect on copeptin concentration with past findings of higher vasopressin during warm season. Speculatively, the contribution of low outdoor temperature to elevated copeptin, which disappears after adjustment for season, may be linked to more long-term mechanisms (behavioral or meteorological).…”

Section: Discussionsupporting

confidence: 80%

Short-term association between outdoor temperature and the hydration-marker copeptin: a pooled analysis in five cohorts

et al. 2023

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“…Goswami et al [ 10 ] found that concentrations of AVP and aquaporin-2 (AQP-2), a biomarker for the renal system response to AVP, were inversely correlated and significantly varied across seasons. They later concluded that the seasonal behavior of AVP and AQP-2 release is the premise of intracellular and extracellular fluid homeostasis [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Seasonality Affects Fluid Intake Behaviors among Young Adults in Hebei, China

Lin,

Zhang,

Zhang

et al. 2024

Nutrients

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Background: Evidence on the association between environmental factors and fluid intake behavior remains limited. The current study aims to explore seasonal variations in fluid intake behaviors among young adults in China. Methods: A prospective cohort of 79 healthy young adults (43 males and 36 females) aged 19–21 in Hebei, China, was assessed for fluid intake behaviors for four seasons. For each assessment, the participants’ anthropometric measurements were collected. Temperature and humidity on survey days were measured. Participants’ total drinking fluid (TDF) was recorded using a self-administrative 7 d, 24 h fluid intake questionnaire. To calculate water from food (WFF), we weighed all foods consumed by participants. Duplicates of consumed food samples were collected to measure the water content via the drying method. Results: The mean total water intake (TWI) was 2761 ± 881, 2551 ± 845, 2210 ± 551, and 1989 ± 579 for spring, summer, fall, and winter, respectively (F(2.37) = 42.29, p < 0.001). The volume and proportion of TWI from TDF and WFF varied across the four seasons. The volume of WFF in spring (1361 ± 281, F(2.61) = 17.21, p < 0.001) and TDF in summer (1218 ± 502, F(2.62) = 9.36, p < 0.001) was among the highest, while participants’ fluid intake behaviors in spring and summer were less distinct than the other pairwise comparisons. A moderate association was found between outdoor temperature and TDF (r = 0.53, p < 0.01). Different general estimating equations suggested that gender, seasonality, outdoor temperature, differences in indoor and outdoor temperature, and mean temperature were independent factors of TDF. An interactive effect was found for gender and temperature, showing that the expected TDF of males may increase more as the temperature climbs. Conclusions: Gender, seasonality, and air temperature could significantly affect fluid intake behaviors, including the amount and type of fluid intake. However, the independent effect of BMI and humidity remains unclear.

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Seasonal rhythms of vasopressin release and aquaporin-2 excretion assure appropriate water conservation in humans

Cited by 5 publications

References 10 publications

Seasonal variation of vasopressin and its relevance for the winter peak of cardiometabolic disease: A pooled analysis of five cohorts

Seasonal variation of vasopressin and its relevance for the winter peak of cardiometabolic disease: A pooled analysis of five cohorts

Short-term association between outdoor temperature and the hydration-marker copeptin: a pooled analysis in five cohorts

Seasonality Affects Fluid Intake Behaviors among Young Adults in Hebei, China

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