Seasonal photoperiodic influence of pineal melatonin on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in male rats

Li, Wenna; Li, Ting; Liu, Leilei; Han, Qi; Zhang, Hairong; Sun, Yike; Hao, Ruisen; Ma, Shuang

doi:10.1016/j.jtcms.2022.03.005

Cited by 2 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Admittedly, the current HPA model does not provide a complete representation of all the underlying dynamics regulating seasonal changes in the circadian timing system. For example, seasonal photoperiod acts on the pineal gland to secret different levels of melatonin, resulting in seasonal changes in the HPA axis receptor, which may be the pathophysiological basis for the onset of seasonal affective disorder ( 55 ). Moreover, the ultradian oscillation of the HPA axis is neglected ( 56 ).…”

Section: Methodsmentioning

confidence: 99%

Light-induced synchronization of the SCN coupled oscillators and implications for entraining the HPA axis

Androulakis

2022

Front. Endocrinol.

View full text Add to dashboard Cite

The suprachiasmatic nucleus (SCN) synchronizes the physiological rhythms to the external light-dark cycle and tunes the dynamics of circadian rhythms to photoperiod fluctuations. Changes in the neuronal network topologies are suggested to cause adaptation of the SCN in different photoperiods, resulting in the broader phase distribution of neuron activities in long photoperiods (LP) compared to short photoperiods (SP). Regulated by the SCN output, the level of glucocorticoids is elevated in short photoperiod, which is associated with peak disease incidence. The underlying coupling mechanisms of the SCN and the interplay between the SCN and the HPA axis have yet to be fully elucidated. In this work, we propose a mathematical model including a multiple-cellular SCN compartment and the HPA axis to investigate the properties of the circadian timing system under photoperiod changes. Our model predicts that the probability-dependent network is more energy-efficient than the distance-dependent network. Coupling the SCN network by intra-subpopulation and inter-subpopulation forces, we identified the negative correlation between robustness and plasticity of the oscillatory network. The HPA rhythms were predicted to be strongly entrained to the SCN rhythms with a pro-inflammatory high-amplitude glucocorticoid profile under SP. The fast temporal topology switch of the SCN network was predicted to enhance synchronization when the synchronization is not complete. These synchronization and circadian dynamics alterations might govern the seasonal variation of disease incidence and its symptom severity.

show abstract

Section: Methodsmentioning

confidence: 99%

Light-induced synchronization of the SCN coupled oscillators and implications for entraining the HPA axis

Androulakis

2022

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

Peculiarities of circadian regulation of the thyroid gland

Boichuk

Popova

2023

Mìžnarodnij endokrinologìčnij žurnal

View full text Add to dashboard Cite

Circadian rhythmicity is an autonomous period of organ cells’ functioning that is controlled by feedback mechanisms and specific genes. The thyroid gland, as a peripheral organ of the endocrine system, is subordinate to the adenohypophysis and pineal gland. Melatonin, as one of the main mediators of circadian influence, is well known for its antitumor and regulatory effects on a number of tissues, but its relationship with the hormone-producing activity of the thyroid gland has not been sufficiently studied. The purpose of the work was to analyze the current data on circadian regulation of the thyroid gland by examining evidence-based scientific publications from open databases over the past five years. Melatonin-producing pineal cells possess the homeotic genes Otx2 and Crx whose deactivation leads to a significant decrease in melatonin production by the pineal gland. In addition to pineal cells, melatonin can be synthesized by adenohypophysis-independent parafollicular cells. The effect of melatonin on thyrocytes is provided by binding to MT1 receptors and affecting the expression of thyroglobulin, RX-8, and TTF-1 (NKX2-1) genes. Under conditions of short photoperiod, melatonin inhibits the production of thyroid-stimulating hormone (TSH) β, which, in turn, acts on hypothalamic tanycytes by regulating the balance of deiodinase (Dio2/Dio3). This leads to a well-regulated seasonal control of the release of the thyroid hormone triiodothyronine. Conclusions. Circadian regulation of thyrocyte activity occurs under the influence of melatonin, which is secreted by pinealocytes and sometimes by parafollicular cells. TSH is secreted with a certain circadian periodicity under the influence of the activation of chronorhythmic genes. Hormone replacement therapy should be aimed not only at restoring the levels of pituitary hormones, but also at restoring the biological rhythm of TSH secretion. Melatonin affects the circadian work of thyrocytes, which is proven by determining the expression of the chronorhythm genes Bmal-1, Dio2, TTF-1. In thyroid pathology, there is a violation of circadian rhythms, a decrease in melatonin levels, and a decrease in the expression of Clock genes.

show abstract

Seasonal photoperiodic influence of pineal melatonin on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in male rats

Cited by 2 publications

References 35 publications

Light-induced synchronization of the SCN coupled oscillators and implications for entraining the HPA axis

Light-induced synchronization of the SCN coupled oscillators and implications for entraining the HPA axis

Peculiarities of circadian regulation of the thyroid gland

Contact Info

Product

Resources

About