Seasonal metabolic profiling of Valencia orange leaf essential oil using GC coupled with chemometrics, nano-formulation, and insecticidal evaluation: <i>in vivo</i> and <i>in silico</i>

Elghani, Eman M. Abd; Sayed, Abeer M. El; Emam, Marwa M. Abdel-Aziz; Al-mahallawi, Abdulaziz Mohsen; Tadros, Soad H.; Soliman, F. A.; Youssef, Fadia S.

doi:10.1039/d2ra06273a

Cited by 4 publications

(3 citation statements)

References 53 publications

(58 reference statements)

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“…Eighty compounds that have been identified by LC-MS from the biologically active extracts of both inspected plants have been subjected to docking simulation against five key proteins in survival and replication of influenza virus [ 37 , 38 ]. Among the docked compounds, the eight identified flavonoid di-glycosides have shown outstanding affinity toward the five examined proteins and achieved docking scores which move toward or even exceeded that achieved by reference compound (oseltamivir) and by the native ligands after re-docking in their original binding pockets ( Table S6 ).…”

Section: Resultsmentioning

confidence: 99%

Comparative metabolomics analysis of Citrus medica var. sarcodactylis Swingle and Limonia acidissima Linn. Fruits and leaves cultivated in Egypt in context to their antiviral effects

El Sayed,

El-Abd,

Afifi

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Comparative metabolomics analysis of Citrus medica var. sarcodactylis Swingle and Limonia acidissima Linn. Fruits and leaves cultivated in Egypt in context to their antiviral effects

El Sayed,

El-Abd,

Afifi

et al. 2024

Heliyon

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“…[69][70][71][72][73][74][75][76][77], and Culex sp. [78][79][80]. Also, it shows antimicrobial [64,[81][82][83], and acaricidal [84] effects.…”

Section: Plants and Nano Formulationsmentioning

confidence: 99%

Tiny Green Army: Fighting Malaria with Plants and Nanotechnology

Moraes-de-Souza,

de Moraes,

Silva

et al. 2024

Pharmaceutics

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Malaria poses a global threat to human health, with millions of cases and thousands of deaths each year, mainly affecting developing countries in tropical and subtropical regions. Malaria’s causative agent is Plasmodium species, generally transmitted in the hematophagous act of female Anopheles sp. mosquitoes. The main approaches to fighting malaria are eliminating the parasite through drug treatments and preventing transmission with vector control. However, vector and parasite resistance to current strategies set a challenge. In response to the loss of drug efficacy and the environmental impact of pesticides, the focus shifted to the search for biocompatible products that could be antimalarial. Plant derivatives have a millennial application in traditional medicine, including the treatment of malaria, and show toxic effects towards the parasite and the mosquito, aside from being accessible and affordable. Its disadvantage lies in the type of administration because green chemical compounds rapidly degrade. The nanoformulation of these compounds can improve bioavailability, solubility, and efficacy. Thus, the nanotechnology-based development of plant products represents a relevant tool in the fight against malaria. We aim to review the effects of nanoparticles synthesized with plant extracts on Anopheles and Plasmodium while outlining the nanotechnology green synthesis and current malaria prevention strategies.

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“…However, the constant and extensive use of chemical insecticides has led to the development of mosquito resistance [6,7] and posed potential toxic effects on public health and environments [8]. Meanwhile, studies have documented the resistance of mosquitoes to insecticides, which may continue to pose challenges for communities in coming decades [9].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Essential Oil from Citrus reticulata Blanco cv. Chachiensis (Chachi) and Its Anti-Mosquito Activity against Pyrethroid-Resistant Aedes albopictus

Cao,

Zheng,

Chen

et al. 2024

Insects

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The overuse of synthetic insecticides has led to various negative consequences, including insecticide resistance, environmental pollution, and harm to public health. This may be ameliorated by using insecticides derived from botanical sources. The primary objective of this study was to evaluate the anti-mosquito activity of the essential oil (EO) of Citrus reticulata Blanco cv. Chachiensis (Chachi) (referred to as CRB) at immature, semi-mature, and mature stages. The chemical compositions of the CRB EO were analyzed using GC-MS. The main components were identified to be D-limonene and γ-terpinene. The contents of D-limonene at the immature, semi-mature, and mature stages were 62.35%, 76.72%, and 73.15%, respectively; the corresponding contents of γ-terpinene were 14.26%, 11.04%, and 11.27%, respectively. In addition, the corresponding contents of a characteristic component, methyl 2-aminobenzoate, were 4.95%, 1.93%, and 2.15%, respectively. CRB EO exhibited significant larvicidal activity against Aedes albopictus (Ae. albopictus, Diptera: Culicidae), with the 50% lethal doses being 65.32, 61.47, and 65.91 mg/L for immature, semi-mature, and mature CRB EO, respectively. CRB EO was able to inhibit acetylcholinesterase and three detoxification enzymes, significantly reduce the diversity of internal microbiota in mosquitoes, and decrease the relative abundance of core species within the microbiota. The present results may provide novel insights into the utilization of plant-derived essential oils in anti-mosquitoes.

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Seasonal metabolic profiling of Valencia orange leaf essential oil using GC coupled with chemometrics, nano-formulation, and insecticidal evaluation: in vivo and in silico

Abstract: Mosquitoes and mosquito-borne infectious diseases are a global challenge, especially with increased resistance to synthetic insecticides.

Cited by 4 publications

References 53 publications

Comparative metabolomics analysis of Citrus medica var. sarcodactylis Swingle and Limonia acidissima Linn. Fruits and leaves cultivated in Egypt in context to their antiviral effects

Comparative metabolomics analysis of Citrus medica var. sarcodactylis Swingle and Limonia acidissima Linn. Fruits and leaves cultivated in Egypt in context to their antiviral effects

Tiny Green Army: Fighting Malaria with Plants and Nanotechnology

Chemical Composition of Essential Oil from Citrus reticulata Blanco cv. Chachiensis (Chachi) and Its Anti-Mosquito Activity against Pyrethroid-Resistant Aedes albopictus

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