Seasonal Influenza Vaccine and Increased Risk of Pandemic A/H1N1‐Related Illness: First Detection of the Association in British Columbia, Canada

Janjua, Naveed Z.; Skowronski, Danuta M.; Salway, Travis; Osei, William; Adams, Evan; Petric, Martin; Sabaiduc, Suzana; Chan, Tracy; Mak, Annie; Lem, Marcus; Tang, Patrick; Patrick, David M.; Serres, Gaston De; Bowering, David

doi:10.1086/656586

Cited by 71 publications

(63 citation statements)

References 18 publications

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“…A reduced HI antibody response against A/California/7/2009 (H1N1) was noted in healthy adults who had previously received a seasonal influenza vaccine. This finding has been presented before in the ferret model (17) as well as in clinical studies (18,19). The mechanism is still uncertain, but the following hypothesis may be considered.…”

Section: Discussionsupporting

confidence: 65%

Long-Term Immunogenicity of the Pandemic Influenza A/H1N1 2009 Vaccine among Health Care Workers: Influence of Prior Seasonal Influenza Vaccination

Song

Cheong

Seo

et al. 2013

Clin Vaccine Immunol

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dHealth care workers (HCWs) are at great risk of influenza infection and transmission. Vaccination for seasonal influenza is routinely recommended, but this strategy should be reconsidered in a pandemic situation. Between October 2009 and September 2010, a multicenter study was conducted to assess the long-term immunogenicity of the A/H1N1 2009 monovalent influenza vaccine among HCWs compared to non-health care workers (NHCWs). The influence of prior seasonal influenza vaccination was also assessed with respect to the immunogenicity of pandemic H1N1 influenza vaccine. Serum hemagglutinin inhibition titers were determined prevaccination and then at 1, 6, and 10 months after vaccination. Of the 360 enrolled HCW subjects, 289 participated in the study up to 10 months after H1N1 monovalent influenza vaccination, while 60 of 65 NHCW subjects were followed up. Seroprotection rates, seroconversion rates, and geometric mean titer (GMT) ratios fulfilled the European Union's licensure criteria for influenza A/California/7/2009 (H1N1) at 1 month after vaccination in both the HCWs and NHCWs, without any significant difference. At 6 months after vaccination, the seroprotection rate was more significantly lowered among the NHCWs than among the HCWs (P < 0.01). Overall, postvaccination (1, 6, and 10 months after vaccination) GMTs for A/California/7/ 2009 (H1N1) were significantly lower among the seasonal influenza vaccine recipients than among the nonrecipients (P < 0.05). In conclusion, HCWs should be encouraged to receive an annual influenza vaccination, considering the risk of repeated exposure. However, prior reception of seasonal influenza vaccine showed a negative influence on immunogenicity for the pandemic A/H1N1 2009 influenza vaccine.

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Section: Discussionsupporting

confidence: 65%

Long-Term Immunogenicity of the Pandemic Influenza A/H1N1 2009 Vaccine among Health Care Workers: Influence of Prior Seasonal Influenza Vaccination

Song

Cheong

Seo

et al. 2013

Clin Vaccine Immunol

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“…This protective effect correlated with a reduction of H5N1 virus replication in the upper respiratory tract and was prevented by vaccination against H3N2 virus infection in three of eight ferrets (38%). This scenario resembles observations made in Canada, where subjects vaccinated against seasonal influenza in previous seasons were more likely to develop severe disease caused by infection with pandemic influenza A/H1N1(2009) viruses (17,40). However, the lack of heterosubtypic immunity in these patients was not confirmed.…”

Section: Discussionsupporting

confidence: 61%

Vaccination against Seasonal Influenza A/H3N2 Virus Reduces the Induction of Heterosubtypic Immunity against Influenza A/H5N1 Virus Infection in Ferrets

Bodewes

Kreijtz

Geelhoed-Mieras

et al. 2011

J Virol

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“…[24][25][26] A recent meta-analysis found that prior receipt of seasonal influenza vaccination may have been associated with moderate protection against influenza A(H1N1)pdm09. 27 This study provides an opportunity to compare the risk of pandemic influenza infection among healthcare workers with and without a history of prior seasonal influenza vaccination.…”

Section: Resultsmentioning

confidence: 99%

Pandemic influenza A(H1N1)pdm09: risk of infection in primary healthcare workers

Hudson¹,

Toop²,

Mangin³

et al. 2013

Br J Gen Pract

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Seasonal Influenza Vaccine and Increased Risk of Pandemic A/H1N1‐Related Illness: First Detection of the Association in British Columbia, Canada

Cited by 71 publications

References 18 publications

Long-Term Immunogenicity of the Pandemic Influenza A/H1N1 2009 Vaccine among Health Care Workers: Influence of Prior Seasonal Influenza Vaccination

Long-Term Immunogenicity of the Pandemic Influenza A/H1N1 2009 Vaccine among Health Care Workers: Influence of Prior Seasonal Influenza Vaccination

Vaccination against Seasonal Influenza A/H3N2 Virus Reduces the Induction of Heterosubtypic Immunity against Influenza A/H5N1 Virus Infection in Ferrets

Pandemic influenza A(H1N1)pdm09: risk of infection in primary healthcare workers

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