Seasonal increases in peripheral innate lymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy

Lao-Araya, Mongkol; Steveling, Esther Helen; Scadding, Guy W.; Durham, Stephen R.; Shamji, Mohamed H.

doi:10.1016/j.jaci.2014.07.029

Cited by 173 publications

(147 citation statements)

References 10 publications

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“…One possible mechanism of the increase in peripheral blood ILC2s during nasal allergen exposure may be that ILC2s are recruited from the bone marrow into circulation. Another group investigated the association between seasonal allergic rhinitis (SAR) and peripheral blood ILC2 levels measured in and out of the grass pollen season from nonatopic, SAR, and SAR individuals who received subcutaneous immunotherapy (SCIT) [109]. Consistent with our findings, the group demonstrated that ILC2 levels were significantly increased in SAR individuals during grass pollen season and this increase was not present in nonatopic and SAR with SCIT individuals.…”

Section: Ilc2s In Human Airway Diseasesupporting

confidence: 78%

“…There are currently only a few human studies investigating ILC2s in allergic rhinitis in humans [108••, 109]. Our group has demonstrated a significant increase in the percent of peripheral blood ILC2s 4 h postnasal cat allergen challenge of cat-allergic individuals compared with diluent challenge in the same individuals at a separate visit [108••].…”

Section: Ilc2s In Human Airway Diseasementioning

confidence: 99%

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Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease

Karta

Broide

Doherty

2016

Curr Allergy Asthma Rep

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Recent discoveries have led to the identification of a novel group of immune cells, the innate lymphoid cells (ILCs). The members of this group are divided into three subpopulations: ILC1s, ILC2s, and ILC3s. ILC2s produce Th2 cytokines, IL-4, IL-5, and IL-13, upon activation by epithelial cell-derived cytokines, lipid mediators (cysteinyl leukotrienes and prostaglandin D2), and TNF family member TL1A and promote structural and immune cell responses in the airways after antigen exposure. In addition, ILC2 function is also influenced by inducible T cell costimulator (ICOS)/ ICOS-ligand (ICOS-L) interactions via direct contact between immune cells. The most common airway antigens are allergens and viruses which are highly linked to the induction of airway diseases with underlying type 2 inflammation including asthma and allergic rhinitis. Based on recent findings linking ILC2s and airway Th2 responses, there is intensive investigation into the role of ILC2s in human disease with the hope of a better understanding of the pathophysiology and the discovery of novel potential therapeutic targets. This review summarizes the recent advances made in elucidating ILC2 involvement in human Th2 airway disease.

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Section: Ilc2s In Human Airway Diseasesupporting

confidence: 78%

Section: Ilc2s In Human Airway Diseasementioning

confidence: 99%

Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease

Karta

Broide

Doherty

2016

Curr Allergy Asthma Rep

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“…Elevated levels of ILC2s in PBMCs of seasonal AR patients during the grass pollen season have been reported, but not outside of this season [20]. An influence on ILC2 levels has also been shown in patients sensitized to mugwort allergen [9].…”

Section: Discussionmentioning

confidence: 99%

Increased Group 2 Innate Lymphoid Cells Are Correlated with Eosinophilic Granulocytes in Patients with Allergic Airway Inflammation

Tan

Fan

et al. 2018

Int Arch Allergy Immunol

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The T helper 2 (Th2)-type response was considered the hypostasis of allergic airway diseases, including asthma and allergic rhinitis (AR). However, more recent studies have suggested that allergic airway inflammation also depends on innate immunity and is closely related to group 2 innate lymphoid cells (ILC2s). This study evaluated the ILC2 levels of asthma subjects, patients with asthma and AR, and healthy individuals, regarding how to investigate the relationship between clinical data and ILC2 levels. It was found that asthma patients and asthma with AR patients had higher ILC2 levels compared to healthy subjects. ILC2s were positively correlated with the percentage of eosinophils in patients with asthma and AR, but not with pulmonary function. ILC2 levels were higher in mild asthma subjects than in patients with severe asthma. This study provides a new interpretation of the pathogenesis of allergic airway inflammation and may provide a new direction for the diagnosis and assessment of allergic airway diseases.

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“…105 Pollen grass subcutaneous immunotherapy (SCIT) was effective in preventing ILC2 accumulation in the blood of seasonal allergic rhinitis patients, demonstrating the potential for therapeutic intervention in attenuating ILC2 responses. 116 These data broadly support a role of ILC2 in the pathogenesis of allergic rhinitis, though factors such as specificity of the antigen may influence ILC2 reactivity.…”

Section: Ilc2 In Human Allergic Diseasementioning

confidence: 52%