Seasonal impact in the frequency of isolated spina bifida

Giardini, Valentina; Russo, Francesca Maria; Ornaghi, Sara; Todyrenchuk, Lyudmyla; Vergani, Patrizia

doi:10.1002/pd.4175

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…The risk factors for MMC occurrence are: folic acid deficiency (seasonal or permanent), presence of 677C > T polymorphism in the methylenetetrahydrofolate reductase gene, hyperthermia, low economic status, antispasmodic (especially valproic acid and carbamazepinum), antihistamine, and sulfonamides drug intake, increased BMI [2].…”

Section: Introductionmentioning

confidence: 99%

“…journals.viamedica.pl/ginekologia_polska Published data concerning prenatal evolution of Chiari Malformation type II (CM II) show that as the pregnancy progresses, hindbrain hernation (HH) degree increases and the fourth ventricle and the venous sinuses are gradually being compressed [6,7]. This leads to inappropriate CSF circulation and progression of HC [2]. In more than 80% of children with CM II, the presence of HC in the postnatal period may entail the necessity of ventriculo-peritoneal shunt (VPS) implantation or endoscopic third ventriculostomy (ETV) [8].…”

Section: Introductionmentioning

confidence: 99%

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Open fetal surgery for myelomeningocele — is there the learning curve at reduction mother and fetal morbidity?

et al. 2020

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Objectives:We aimed to show how increased experience of a surgery team in fMMC repair influences maternal and fetal/neonatal outcomes. Material and methods:We compare perinatal results of fMMC repair in our Fetal Surgery Center (FSC) in cohort groups for the early period (2005)(2006)(2007)(2008)(2009)(2010)(2011) year; previous -PFSC, n = 46) and current period (2012)(2013)(2014)(2015) year; current -CFSC, n = 74) to results of the randomized Management of Myelomeningocele Study (MOMS, 78 patients). Results:The maternal morbidity due to fMMC repair was low and there was no difference comparing CFSC to PFSC and MOMS. The frequency of iatrogenic preterm labor (iPTL) ≤ 30 weeks of gestation decreased from 34.1% in PFSC to 23.9% in CFSC. Iatrogenic preterm premature rupture of membranes (iPPROM) was a common complication after fMMC repair in all cohorts. The total reduction rate of hindbrain hernation (HH) was similar in CFSC -90.3% and PFSC -82.1%. Conclusions:The increasing experience of our surgery team in fMMC repair majorly decreased the risk of iPTL.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Open fetal surgery for myelomeningocele — is there the learning curve at reduction mother and fetal morbidity?

et al. 2020

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“…It occurs if neurulation is not completed, which physiologically should happen between the 15th and 30th day after conception [1]. MMC affects about 3–4 per 10,000 live births [2].…”

Section: Introductionmentioning

confidence: 99%

Alternative Hysterotomy Technique for the Reduction of Prenatal Complications of Intrauterine Myelomeningocele Repair

et al. 2020

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Introduction: The main aim of the fetal surgery of myelomeningocele (MMC) is the improvement in prognosis for children with this defect and at the same time high safety of the procedure for mother and fetus. Objective: The aim of the study was to determine the effectiveness of alternative hysterotomy technique for fetal surgery of MMC in prevention of essential perinatal complications. Methods: Forty-nine pregnant women diagnosed with fetal MMC (fMMC) who underwent classic hysterotomy without the use of stapler formed the study cohort. Two cases of intrauterine fetal death or neonatal death in the immediate perioperative period in the study group (SG) were excluded from further analyses. In the historical control group (46 patients) from our center hysterotomy was performed according to Management of Myelomeningocele Study (MOMS) protocol. The study cohort’s outcomes were compared with the historical controls and with post-MOMS results in Children’s Hospital of Philadelphia (CHOP) and Vanderbilt University Medical Center (VUMC). Results: In the SG we did not observe delivery before 30 weeks of gestation (0/47; 0%) and the incidence of chorionamniotic membrane separation (CMS, 3/47; 6%) and preterm premature rupture of membranes (PPROM, 7/47; 15%) was lower compared to the other groups. Preterm delivery as a result of uterine contractions occurred significantly less frequently in the SG (8/47; 17%). Fetal surgery with classic hysterotomy resulted in rare use of magnesium sulfate (3/47; 6%). Conclusions: The alternative hysterotomy technique for fetal surgery of MMC results in low occurrences of CMS, PPROM, preterm delivery, and the rare use of tocolytics.

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Folate and phototherapy: What should we inform our patients?

Zhang

Goyert

Lim

2017

Journal of the American Academy of Dermatology

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Seasonal impact in the frequency of isolated spina bifida

Abstract: Seasonality affects the frequency of ISB. We hypothesize that the seasonal differences may reflect dietary and climate changes with reduced intake of folic acid in the fall.

Cited by 5 publications

References 10 publications

Open fetal surgery for myelomeningocele — is there the learning curve at reduction mother and fetal morbidity?

Open fetal surgery for myelomeningocele — is there the learning curve at reduction mother and fetal morbidity?

Alternative Hysterotomy Technique for the Reduction of Prenatal Complications of Intrauterine Myelomeningocele Repair

Folate and phototherapy: What should we inform our patients?

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