Seasonal Hay Fever and Asthma Treated with Pollen Extracts

Aw, Frankland

doi:10.1159/000228145

Cited by 18 publications

(3 citation statements)

References 1 publication

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“…Furthermore, the allergens in the dandruff extract may be more stable than the pollen allergens which also would contribute to the differences obtained. The diluted extracts lost their activity more rapidly than the more concentrated solutions which is consistent with the findings of other workers (Frankland, 1955;Augustin & Hayward, 1962;McKaba & Sussdorf, 1967). This instability of diluted allergen is probably dependent on the lower concentration of both allergenic and non-allergenic protein.…”

Section: Discussionsupporting

confidence: 91%

Studies on the stability of diluted allergen extracts using the radioallergosorbent test (RAST)

Foucard

Bennich

Johansson

1973

Clin Experimental Allergy

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Summary Allergen extracts from birch pollen, timothy pollen and horse dandruff were investigated. The influence of storage time, volume of extract in the vial and various additives on the potency of diluted extracts was tested with the radioallergosorbent test (RAST). The potency of diluted pollen extracts was found to decrease more rapidly than the potency of diluted dandruff extracts. The differences in allergen activity seen in RAST between freshly diluted extracts and stored extract dilutions were roughly reproducible in skin tests and histamine release tests from passively sensitized chopped human lung. The higher allergen stability of the dandruff extracts could, at least in part, be explained by the higher protein content of these extracts. An adsorption of allergen to the glass wall was shown to be the most probable cause to the more rapid decrease of allergen activity seen in pollen extracts stored in vials only partly filled. With addition of 0.2% Tween 20 after storage the potency of the extracts became almost equivalent to that of corresponding dilutions stored in filled vials.

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Section: Discussionsupporting

confidence: 91%

Studies on the stability of diluted allergen extracts using the radioallergosorbent test (RAST)

Foucard

Bennich

Johansson

1973

Clin Experimental Allergy

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“…DISCUSSION Freeman (10) showed as early as 1911 that there is a crossreactivity between different grass pollens, and he drew the conclusion that timothy pollen extracts used alone were sufficient for skin testing and hyposensitization of grass pollen allergies. The same opinion was presented in 1943 by Juhlin-Dannfelt (17), and in 1955 by Frankland (9).…”

Section: Resultssupporting

confidence: 54%

Cutaneous Reactions to Pollen Extracts in Patients With Hay Fever. Special References to Grass Pollen Recommended for Treatment in Fixed Combination

Löfkvist¹,

Svensson²

1975

Allergy

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“…He considered that an extract of Timothy pollen alone should be sufficient for using in intracutaneous tests and hyposensitization of grass pollen allergies. Bray (1937)) Juhlin-Dannfeldt (1944), Fitzgerald & Sherman (1949) and Frankland (1955) came to the same conclusion.…”

mentioning

confidence: 99%

The Significance of Testingand Hyposensitization With Severalgrass Pollens for Hay Fever

Heijer

Göransson

1968

Allergy

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Seasonal Hay Fever and Asthma Treated with Pollen Extracts

Cited by 18 publications

References 1 publication

Studies on the stability of diluted allergen extracts using the radioallergosorbent test (RAST)

Studies on the stability of diluted allergen extracts using the radioallergosorbent test (RAST)

Cutaneous Reactions to Pollen Extracts in Patients With Hay Fever. Special References to Grass Pollen Recommended for Treatment in Fixed Combination

The Significance of Testingand Hyposensitization With Severalgrass Pollens for Hay Fever

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