Seasonal Expression of Gonadotropin Genes in the Pituitary and Testes of Male Plateau Zokor (Eospalax baileyi)

An, Kang; Yao, Baohui; Kang, Yukun; Bao, Mingfang; Tan, Yuchen; Pu, Qiangsheng; Su, Jian

doi:10.3390/ani12060725

Cited by 9 publications

(3 citation statements)

References 56 publications

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“…This expression was also detected in spermatocytes, spermatids, spermatozoa and spermatogonia. Although this finding is different from present thoughts that Fshr is only present in Sertoli cells but not in other cell types of the testis, our finding is in line with previous works in fishes (including African catfish, zebrafish, teleosts, and Japanese eels) 40–45 , rats 46 , dogs 47 and humans 48 performed by IHC and in situ hybridization. In humans, Fshr was also highly expressed in Leydig cells, although the non-specificity of the anti-Fshr antibodies was noted.…”

Section: Discussionsupporting

confidence: 86%

Atlas of Fshr Expression from Novel Reporter Mice

Chen,

Fang,

Liu

et al. 2023

Preprint

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Section: Discussionsupporting

confidence: 86%

Atlas of Fshr Expression from Novel Reporter Mice

Chen,

Fang,

Liu

et al. 2023

Preprint

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“…For example, in Syrian hamsters, spermatogenesis stagnates at the spermatocyte stage [ 62 ]. Spermatogenesis in the plateau pika ( Ochotona curzoniae ) and plateau zokor ( Eospalax baileyi ) is blocked at the undifferentiated spermatogonia stage [ 81 , 82 ]. During the non-breeding season, the convoluted tubules of the Japanese field mouse ( Apodemus speciosus ) only contained spermatogonia and a large number of apoptotic spermatocytes [ 83 ].…”

Section: Potential Relationship Between Amh and Seasonal Reproductionmentioning

confidence: 99%

Potential Role of Anti-Müllerian Hormone in Regulating Seasonal Reproduction in Animals: The Example of Males

Yao

Tan

et al. 2023

IJMS

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Seasonal reproduction is a survival strategy by which animals adapt to environmental changes to improve their fitness. Males are often characterized by a significantly reduced testicular volume, indicating that they are in an immature state. Although many hormones, including gonadotropins, have played a role in testicular development and spermatogenesis, research on other hormones is insufficient. The anti-Müllerian hormone (AMH), which is a hormone responsible for inducing the regression of Müllerian ducts involved in male sex differentiation, was discovered in 1953. Disorders in AMH secretion are the main biomarkers of gonadal dysplasia, indicating that it may play a crucial role in reproduction regulation. A recent study has found that the AMH protein is expressed at a high level during the non-breeding period of seasonal reproduction in animals, implying that it may play a role in restricting breeding activities. In this review, we summarize the research progress on the AMH gene expression, regulatory factors of the gene’s expression, and its role in reproductive regulation. Using males as an example, we combined testicular regression and the regulatory pathway of seasonal reproduction and attempted to identify the potential relationship between AMH and seasonal reproduction, to broaden the physiological function of AMH in reproductive suppression, and to provide new ideas for understanding the regulatory pathway of seasonal reproduction.

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“…The plateau zokor ( Eospalax baileyi ) belongs to the genus Eospalax (Spalacidae, Rodentia), the species which spend most of their life in closed, underground tunnel systems at an altitude of 3200–3800 m, mainly feeding on the belowground rhizomes of forbs [ 11 , 12 ]. The plateau zokor is the dominant herbivorous, small mammal in the alpine meadow of the Qinghai-Tibet Plateau (QTP), and it plays an important role in the material cycles and energy flow of the alpine grassland ecosystem [ 13 , 14 , 15 ]. In terms of its evolution, the plateau zokor differentiated due to the uplift of the QTP (3.6 million years ago), and it developed morphological, physiological, and behavioral adaptations for foraging and living in the underground tunnel environments of high-altitude areas [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

The Complex and Well-Developed Morphological and Histological Structures of the Gastrointestinal Tract of the Plateau Zokor Improve Its Digestive Adaptability to High-Fiber Foods

Cai

Bao

et al. 2022

Animals

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The morphological and histological traits of the gastrointestinal tract (GIT) enable the animal to perform some specific functions that enhance the species’ adaptability to environments. The plateau zokor (Eospalax baileyi) is a subterranean rodent that mainly forages on plant roots in the Qinghai-Tibet Plateau, but little is known about the mechanism by which the plateau zokor digests roots that have high fiber contents. In this study, we used comparative anatomy methods to compare the morphological and histological traits of the GIT of both the plateau zokor and the plateau pika (Ochotona curzoniae), a small, fossorial lagomorph that forages aboveground plant parts, in order to clarify the traits of the plateau zokor’s GIT and to understand its adaptations to high-fiber foods. The results showed that the foods which plateau zokors eat have a higher fiber content than those which the plateau pikas eat. The plateau zokor has a double-chambered and hemi-glandular stomach (the tubular glands are only in the gastric corpus II, and the gastric fundus is keratinized), whereas the plateau pika has a simple, wholly glandular stomach. The gross morphological indicators (organ index and relative length) of the GIT were significantly lower in the plateau zokor than they were in the plateau pika (p < 0.001). However, the thickness of the gastric corpus II mucosal layer and the gastric fundus muscle layer are significantly higher in the plateau zokor than they are in the plateau pika (p < 0.001), and the thickness of each layer of intestinal tissue is higher in the plateau zokor than it is in the plateau pika. Additionally, the small intestinal villi also are higher and wider in the plateau zokor than they are in the plateau pika. Our results suggest that instead of adapting to digest the high-fiber diet by expanding the size of the GIT, the plateau zokor has evolved a complex stomach and a well-developed gastrointestinal histological structure, and that these specialized GIT structures are consistent with an optimal energy-economy evolutionary adaptation strategy.

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Seasonal Expression of Gonadotropin Genes in the Pituitary and Testes of Male Plateau Zokor (Eospalax baileyi)

Cited by 9 publications

References 56 publications

Atlas of Fshr Expression from Novel Reporter Mice

Atlas of Fshr Expression from Novel Reporter Mice

Potential Role of Anti-Müllerian Hormone in Regulating Seasonal Reproduction in Animals: The Example of Males

The Complex and Well-Developed Morphological and Histological Structures of the Gastrointestinal Tract of the Plateau Zokor Improve Its Digestive Adaptability to High-Fiber Foods

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