Seasonal effect of GnIH on gonadotrope functions in the pituitary of goldfish

Goldfish neurokinin B: Cloning, tissue distribution, and potential role in regulating reproduction

“…In the present study, we observed that only sGnRH, but not cGnRH-II, is induced by NKBs. Since our study was performed during one stage of gonadal development and many neuropeptides are known to exert gonadal stage-specific effects (Habibi et al, 1989;Moussavi et al, 2012Moussavi et al, , 2013Peng et al, 1993), we cannot exclude the possibility that NKBs may regulate cGnRH-II in other stages of reproductive cycle.…”

How to contribute to the progress of neuroendocrinology: New insights from discovering novel neuropeptides and neurosteroids regulating pituitary and brain functions

“…Goldfish GnIH precursor cDNA encodes three GnIHs, gfLPXRFa-1, -2 and -3 (Sawada et al, 2002b). Goldfish GnIH peptides, LPXRFa-1, -2 and -3, have both inhibitory and stimulatory effects on gonadotropin synthesis and release possibly depending on reproductive conditions (Amano et al, 2006;Moussavi et al, 2012Moussavi et al, , 2013Qi et al, 2013). Zebrafish GnIH peptide, zfLPXRF-3, has also an inhibitory effect on gonadotropin release (Zhang et al, 2010).…”

GnIH plays a negative role in regulating GtH expression in the common carp, Cyprinus carpio L.

“…In goldfish, injecting zebrafish LPXRFa-3 peptide decreased LH expression (Zhang et al, 2010). Physiological status may also influence the results of peptide injection or incubation experiments (Moussavi et al, 2012).…”

“…Administration of the GnIH-II peptide to tilapia pituitary cells or intraperitoneal injection of female tilapia resulted in an increase in FSH and LH proteins (Biran et al, 2014). It was also reported that regulation of LH secretion and gonadotropin subunit mRNA levels are dissociated in the presence of gGnIH and dependent on maturational status and administration route (Moussavi et al, 2012).…”