Seasonal differences and the effect of insulin on pyruvate uptake, oxidation and synthesis to glycogen by frog skeletal muscle

Gourley, D. R. H.; Suh, Tae Kyu; Brunton, Laurence L.

doi:10.1016/0010-406x(69)91603-x

Comparative Biochemistry and Physiology

1969

DOI: 10.1016/0010-406x(69)91603-x

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Seasonal differences and the effect of insulin on pyruvate uptake, oxidation and synthesis to glycogen by frog skeletal muscle

D. R. H. Gourley

Tae Kyu Suh

Laurence L. Brunton

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1970

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Cited by 20 publications

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“…It follows that hormones involved in the regulation of carbohydrate metabolism should be expected to exhibit seasonally variable effects. Insulin favors glycogen synthesis from pyruvate in frog muscle isolated from winter R. pipiens but favors pyruvate oxidation in summer frog muscle (Gourley et al, 1969). Rana temporaria often die after insulin (4 IU/kg) in summer but may show a lack of response for a few hours following the same dose in winter (Hanke and Neumann, 1972).…”

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Seasonal variation in the effects of adrenalin and glucagon in Rana pipiens

Farrar

Frye

1977

General and Comparative Endocrinology

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confidence: 99%

Seasonal variation in the effects of adrenalin and glucagon in Rana pipiens

Farrar

Frye

1977

General and Comparative Endocrinology

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Seasonal effects of hyper‐osmotic sodium chloride on urea production in the frog, Rana pipiens

Jungreis

1971

J. Exp. Zool.

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ABSTRACT1. Spring-summer frogs, Rana pipiens, acclimated at 22.5"C or 27°C were dehydrated in 0.15 M NaCl for up to 24 hours. After 10 or 24 hours of treatment, the concentration of urea in serum increases relative to the concentrations of urea measured in serum of frogs kept in tap water or 0.125 M NaC1.The increase in the concentration of urea in serum of spring-summer frogs was associated with an increase in body urea and an increased rate of urea production.When fall-winter frogs, acclimated at 20°C, were dehydrated in 0.15 M NaCl for 12.5 hours, no increase in the concentration of urea in serum was observed, relative to frogs treated with tap water or 0.125 M NaC1. After 48 hours, the concentration of urea in serum of frogs treated with 0.15 M or 0.125 M NaCl was the same, but both were significantly greater than tap water treated frogs.4. The metabolic basis for the increase in the rate of urea production observed in spring-summer but not fall-winter frogs in response to hyperosmotic sodium chloride is discussed. 2. 3.In the course of a preliminary study designed to explore the relationships between the activities of liver and kidney enzymes associated with urea production and the proportion of waste nitrogen excreted as ammonia or urea, it was observed that, following short term mild dehydration in air, leopard frogs ( R a m pipiens) in the spring and summer but not in the fall and winter had higher concentrations of urea in serum than did tap water treated frogs (Jungreis, '71). While the increased concentrations of urea in serum of spring-summer frogs were suggestive of an increased rate of urea production, the inability to quantitatively collect excreted urine made it impossible to conclude that the increased concentration represents an increase in urea production. Consequently, a different type of dehydration was employed which would permit quantitative determination of both the quantity of urea excreted as well as the quantity of urea retained in the animal's body.When frogs Rana pipiens were dehydrated in 0.15 M NaCl (hyper-osmotic to J. EXP. ZOOL., 178: 403-414 serum colloid osmotic pressure) for under 24 hours, spring-summer but not fallwinter animals were observed to have increased concentrations of urea in serum.When total urea excretion was simultaneously measured, an increase in urea production was found to have accompanied the increased concentration of urea in serum.

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Physiological responses of larval and postmetamorphic Rana pipiens to growth hormone and prolactin

Snyder¹,

Frye²

1972

J. Exp. Zool.

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Bovine prolactin stimulates growth of tadpoles, whereas bovine growth hormone stimulates growth of postmetamorphic frogs. The biochemical composition of liver, muscle, and fat body were examined to determine whether there were any changes i n carbohydrate, protein, fat, or nucleic acids which might correlate significantly with the growth effects of the hormones i n the two stages of development. In the frog, the major effect of growth hormone was to depress carbohydrate and lipid stores, with little or no effect on protein and nucleic acids in most experiments. Prolactin had similar but smaller effects on carbohydrate, and no effect on fat body lipid in the frog. I n tadpoles prolactin suppressed muscle glycogen, but otherwise did not affect tissue composition. Growth hormone had no effects i n the tadpole. Ways in which the interrelated developmental and metabolic effects of growth hormone and prolactin could increase the adaptive significance of distinct larval and postmetamorphic growth-regulating hormones in the amphibians are discussed. 3 In one exceptional case (Enmar et al., '68) both prolactin and growth hormone were effective in increasing length and weight of Rana temporaria larvae, the latter being the more effective of the two hormones.

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Seasonal differences and the effect of insulin on pyruvate uptake, oxidation and synthesis to glycogen by frog skeletal muscle

Cited by 20 publications

References 20 publications

Seasonal variation in the effects of adrenalin and glucagon in Rana pipiens

Seasonal variation in the effects of adrenalin and glucagon in Rana pipiens

Seasonal effects of hyper‐osmotic sodium chloride on urea production in the frog, Rana pipiens

Physiological responses of larval and postmetamorphic Rana pipiens to growth hormone and prolactin

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