Seasonal cocaine abuse

Sl, Satel; Fh, Gawin

doi:10.1176/ajp.146.4.534

Cited by 17 publications

(1 citation statement)

References 13 publications

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“…One of the earliest hints of an interaction between cocaine and the circadian system arose from studies of patients with seasonal affective disorder and seasonal variations in cocaine abuse [ 321 , 322 ]. Subsequent research in rodent models found that the effects of acute cocaine exposure on locomotor activity were dependent upon the time of day [ 323 ] as was cocaine-induced behavioral sensitization [ 324 – 326 ].…”

Section: Interactions Of the Circadian System With Cocainementioning

confidence: 99%

Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse

Nobrega

Lyons

2017

Neural Plasticity

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Endogenous circadian oscillators orchestrate rhythms at the cellular, physiological, and behavioral levels across species to coordinate activity, for example, sleep/wake cycles, metabolism, and learning and memory, with predictable environmental cycles. The 21st century has seen a dramatic rise in the incidence of circadian and sleep disorders with globalization, technological advances, and the use of personal electronics. The circadian clock modulates alcohol- and drug-induced behaviors with circadian misalignment contributing to increased substance use and abuse. Invertebrate models, such as Drosophila melanogaster, have proven invaluable for the identification of genetic and molecular mechanisms underlying highly conserved processes including the circadian clock, drug tolerance, and reward systems. In this review, we highlight the contributions of Drosophila as a model system for understanding the bidirectional interactions between the circadian system and the drugs of abuse, alcohol and cocaine, and illustrate the highly conserved nature of these interactions between Drosophila and mammalian systems. Research in Drosophila provides mechanistic insights into the corresponding behaviors in higher organisms and can be used as a guide for targeted inquiries in mammals.

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Section: Interactions Of the Circadian System With Cocainementioning

confidence: 99%

Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse

Nobrega

Lyons

2017

Neural Plasticity

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Daily cocaine craving in a 3-week inpatient treatment program

et al. 1993

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Fifteen male veteran cocaine addicts took simple tests of cocaine craving, mood, energy, and perceived health status for 23 consecutive days during an inpatient treatment center. Results show they experienced very little cocaine craving or other symptomatology. Multiple regression analyses show that health rating alone was the best predictor of cocaine craving. These results question solely internal sources of craving and the oft‐touted craving‐depression connection. The study delineates further implications of the findings.

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Cocaine

Brust

2004

Neurological Aspects of Substance Abuse

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Seasonal cocaine abuse

Abstract: The authors describe two patients with seasonal affective disorder characterized by fluctuations in cocaine craving that paralleled seasonal dysphoria. This extends the range of axis I disorders associated with cocaine self-administration.

Cited by 17 publications

References 13 publications

Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse

Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse

Daily cocaine craving in a 3-week inpatient treatment program

Cocaine

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