Seasonal changes in plasma testosterone and cortisol suggest an androgen mediated regulation of the pituitary adrenal axis in the Tarabul’s gerbil Gerbillus tarabuli (Thomas, 1902)

Zatra, Yamina; Aknoun-Sail, Naouel; Kheddache, Arezki; Benmouloud, Abdelouafi; Charallah, Salima; Moudilou, Elara; Exbrayat, Jean-Marie; Khammar, Farida; Amirat, Zaïna

doi:10.1016/j.ygcen.2017.08.012

Cited by 7 publications

(6 citation statements)

References 51 publications

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“…The Spearman’s correlation analysis performed between hair CORT and TEST showed an inversely proportional trend (ρ = −0.56; Figure 3 ). When discussing this finding, different factors need to be taken into consideration [ 31 ]: one being that androgens, for example, seem to inhibit the stress-induced levels of CORT [ 32 ]. This possible explanation does not hold true for the blood results, since no correlation (ρ = 0.07) between blood concentrations of CORT and TEST were noticed.…”

Section: Discussionmentioning

confidence: 99%

Hair Testosterone and Cortisol Concentrations in Pre- and Post-Rut Roe Deer Bucks: Correlations with Blood Levels and Testicular Morphometric Parameters

Ventrella

Elmi

Barone

et al. 2018

Animals

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Simple SummaryThe roe deer is a very common wild species in Italy and shows peculiar reproductive characteristics. Sexually-mature males, called bucks, show a complete interruption in spermatogenesis during the cold seasons. The mechanisms behind such interruption are still partially unknown. Hair is a good biological sample, easy to obtain while minimizing stress, for endocrinological analyses that may provide information regarding such mechanisms. The aim of the work was to quantify and compare hair concentrations of testosterone and cortisol in wild roe deer bucks hunted during the pre- and post-rut period (mating season). The secondary objective was the evaluation of possible correlations of such hair concentrations with blood and morphometric parameters of the testes. Testosterone significantly increased from the pre- to post-rut period, while cortisol significantly decreased. The correlations with blood and testicular parameters resemble what is already described in the literature. Overall, this study represents a first report of the quantification of testosterone and cortisol in roe deer hair, and may provide interesting insights into their reproductive physiology.AbstractThe roe deer is a seasonally breeding species with a reproductive cycle regulated by endogenous rhythms and photoperiod-sensitivity. Sexually mature bucks show hormonal and testicular activation during the reproductive season, with a peak in the rut period, and following gradual involution. Hair is a good matrix for non-invasive endocrinological analyses that provide long-term information without being influenced by the hormones’ pulsating release patterns in blood. The aim of the work was to quantify hair concentrations of testosterone and cortisol in wild roe deer bucks hunted during the pre- and post-rut period, using a radioimmunoassay methodology, and to look for differences between the two periods. The secondary objective was the evaluation of possible correlations of such hair concentrations with blood and morphometric parameters of the testes. Both hormones showed statistical differences, with opposing trends, when comparing the two periods: testosterone increased while cortisol decreased. The correlation analysis was in agreement with existing literature regarding metabolism/actions of these hormones and testicular morphometric parameters. This study represents the first report of the use of radioimmunoassay techniques to quantify testosterone and cortisol in roe deer hair, and may provide interesting insights into their reproductive physiology.

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Section: Discussionmentioning

confidence: 99%

Hair Testosterone and Cortisol Concentrations in Pre- and Post-Rut Roe Deer Bucks: Correlations with Blood Levels and Testicular Morphometric Parameters

Ventrella

Elmi

Barone

et al. 2018

Animals

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“…Thus, testosterone may be involved, at least in part, in determining the annual variations in adrenocortical activity. 43 Reproductive axis. Due to its seasonal reproduction, this gerbil is an important tool for studying the reproductive system.…”

Section: G Tarabuli Is An Attractive Rodent Model For Biological Rese...mentioning

confidence: 99%

“…43 The effect of gonadectomy, which induces significant weight, histological, and hormonal changes in the adrenal gland, on the pituitary–adrenal axis during the breeding season has been studied. Testosterone withdrawal activates corticosteroidogenesis, induces adrenal cortex hypertrophy, greater androgen receptor positivity, increases plasma cholesterol, and decreases ACTH, 43 –45 suggesting negative modulation of testosterone on the pituitary-adrenal axis of G. tarabuli , by acting directly on the adrenal cortex and/or probably via the central pathway by modulating the hypothalamic-pituitary hormonal activity. Thus, testosterone may be involved, at least in part, in determining the annual variations in adrenocortical activity.…”

Section: Introductionmentioning

confidence: 99%

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Advances in research on the biology of the desert rodent Gerbillus tarabuli: a review

et al. 2022

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Selection of the appropriate species and strain of laboratory animals are among the scientist’s major concerns. Tarabul’s gerbil ( Gerbillus tarabuli) is a small, seasonally breeding, desert rodent native to Africa. Despite its unique biological features, which make it an ideal model candidate for biomedical research, only a few reports have used it in research. Hence, the present review aims to provide more data about this species, covering all aspects of its biology, such as taxonomy, morphology, anatomy, ecology, wildlife biology, molecular biology, physiology, neurobiology, genetics, reproduction, development, evolutionary biology, and conservation biology, and covers current progress in exploration of G. tarabuli, discussing its valuable characteristics, which are widely useful for research in various fields. This review paper is destined for biologists, scientists, mammologists, zoologists, academics, and students.

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“…On the other hand, this pathway is regulated by gonadal hormones with probably a stimulating action of estrogen and an inhibitory action of androgens on the inner areas. The sex hormones mediate pituitary adrenal axis responsiveness to stress since the estrogen increased ACTH and corticosterone secretion in rats [28] while the androgen decreased the CRH, ACTH, and corticosterone concentrations both in the laboratory animals [23,27] and the non-laboratory animals such as Psammomys obesus [5], Meriones libycus [1] and Gerbillus tarabuli [29]. Sex hormones also act on adrenal androgens with, in particular, a stimulatory effect of estrogens in humans on the secretion of DHEA [21] and an indirect inhibitory effect by inhibiting the expression of 3β-HSD in the mouse [24].…”

Section: Discussionmentioning

confidence: 99%

Sex differences in adrenal cortex beta-catenin immunolocalisation of the Saharan gerbil, Libyan jird (Meriones libycus, Lichtenstein, 1823)

et al. 2023

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Seasonal changes in plasma testosterone and cortisol suggest an androgen mediated regulation of the pituitary adrenal axis in the Tarabul’s gerbil Gerbillus tarabuli (Thomas, 1902)

Cited by 7 publications

References 51 publications

Hair Testosterone and Cortisol Concentrations in Pre- and Post-Rut Roe Deer Bucks: Correlations with Blood Levels and Testicular Morphometric Parameters

Hair Testosterone and Cortisol Concentrations in Pre- and Post-Rut Roe Deer Bucks: Correlations with Blood Levels and Testicular Morphometric Parameters

Advances in research on the biology of the desert rodent Gerbillus tarabuli: a review

Sex differences in adrenal cortex beta-catenin immunolocalisation of the Saharan gerbil, Libyan jird (Meriones libycus, Lichtenstein, 1823)

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