Seasonal Changes in Kidney Function in CKD of Uncertain Etiology

Arora, Sahil; Priyamvada, P S; Sahoo, Jayaprakash; Vairappan, Balasubramaniyan; Parameswaran, Sreejith

doi:10.1016/j.ekir.2021.08.011

Cited by 2 publications

(2 citation statements)

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“…Also known as CKD of non-traditional cause, chronic interstitial nephritis in agricultural communities, Mesoamerican nephropathy and Uddanam Nephropathy, CKDu has been observed largely in the Global South, including India, Sri Lanka, parts of Africa, and Central and South America 49,51,52 . One study of people with CKDu in India found worsening of metabolic acidosis and hypertension in summer compared with winter, supporting the hypothesis that a warming planet also threatens kidney health 50 . Increasing salinity of drinking water in coastal areas of Bangladesh affected by rising sea levels has also been linked to increased rates of preeclampsia and gestational hypertension, in addition to hypertension and albuminuria in the general population, all of which are risk factors for subsequent kidney disease [53][54][55] .…”

Section: Environmental and Social Threats To Kidney Health Continue T...mentioning

confidence: 91%

“…This condition is characterized by the presence of a benign urinary sediment and tubulointerstitial changes on biopsy 47 . Proposed mechanisms include recurrent heat stress with repeated episodes of AKI and exposure to environmental toxins, including pesticides and heavy metals [48][49][50][51] . Also known as CKD of non-traditional cause, chronic interstitial nephritis in agricultural communities, Mesoamerican nephropathy and Uddanam Nephropathy, CKDu has been observed largely in the Global South, including India, Sri Lanka, parts of Africa, and Central and South America 49,51,52 .…”

Section: Environmental and Social Threats To Kidney Health Continue T...mentioning

confidence: 99%

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Chronic kidney disease and the global public health agenda: an international consensus

Francis,

Harhay,

Ong

et al. 2024

Nat Rev Nephrol

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Early detection is a key strategy to prevent kidney disease, its progression and related complications, but numerous studies show that awareness of kidney disease at the population level is low. Therefore, increasing knowledge and implementing sustainable solutions for early detection of kidney disease are public health priorities. Economic and epidemiological data underscore why kidney disease should be placed on the global public health agenda -kidney disease prevalence is increasing globally and it is now the seventh leading risk factor for mortality worldwide. Moreover, demographic trends, the obesity epidemic and the sequelae of climate change are all likely to increase kidney disease prevalence further, with serious implications for survival, quality of life and health care spending worldwide. Importantly, the burden of kidney disease is highest among historically disadvantaged populations that often have limited access to optimal kidney disease therapies, which greatly contributes to current socioeconomic disparities in health outcomes. This joint statement from the International Society of Nephrology, European Renal Association and American Society of Nephrology, supported by three other regional nephrology societies, advocates for the Nature Reviews Nephrology Consensus statementAfrica, Europe and Asia-Pacific, across adult and paediatric nephrology. Over several meetings, the authorship team discussed current and future challenges, as well as strategies for increasing global awareness of CKD and decreasing its global impact, to develop this Consensus Statement and recommendations. The manuscript was reviewed by various regional representative bodies (ISN Regional Boards), and consensus was attained. The ISN has established a regional board in each of its 10 regions -

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Section: Environmental and Social Threats To Kidney Health Continue T...mentioning

confidence: 91%

Section: Environmental and Social Threats To Kidney Health Continue T...mentioning

confidence: 99%

Chronic kidney disease and the global public health agenda: an international consensus

Francis,

Harhay,

Ong

et al. 2024

Nat Rev Nephrol

View full text Add to dashboard Cite

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Chronic Kidney Disease of Unknown Etiology (CKDu) – The Search for Causes and the Impact of Its Politicization

Dharma‐wardana¹

2023

Medical Geology

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Kidney disease of unknown aetiology (CKDu) has been identified in many countries extending from MesoAmerica and Egypt, to South-east Asia and China. Although CKDu has been linked by various authors to farming, it is an artifact of treating multi-modal disease distributions as unimodal. There is NO correlation of CKDu with agriculture since affected farming villages are often surrounded by other farming villages free of CKDu. Initial studies looked for a correlation of CKDu with toxic heavy metal residues of arsenic, cadmium etc., or herbicides like glyphosate that may be present in the environment, as the causative factors. There is now considerable consensus that their concentrations are below danger thresholds, be it in Mesoamerica or south-east Asia. The conceptual basis of a search for etiology within a systems approach is discussed, and attempts to name the disease to bias the identification of its etiology are reviewed. Current research has narrowed down the etiology to geochemical electrolytic contaminants like fluorides and ionic components in hard water, nanosilica (found in water as well as in the air), as well as renal toxins similar to indoxyl sulphates that may arise from interactions of ions with humic acids contained in aqueous organic matter. However, while agrochemical toxins are increasingly considered less relevant to the etiology of CKDu, it has become a firm public belief. In Sri Lanka this has spawned ideology-based agricultural policies for partial and complete banning of agrochemicals (2014-2021), followed by some back-tracking, disrupting the economy and the food supply. A farmer's uprising in 2022 was spawned by poor harvests. It triggered a larger popular uprising that led to the collapse of a government wedded to romanticized eco-extremist agricultural policies in a country already facing difficulties in the wake of Covid and Ukraine.

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Seasonal Changes in Kidney Function in CKD of Uncertain Etiology

Cited by 2 publications

References 10 publications

Chronic kidney disease and the global public health agenda: an international consensus

Chronic kidney disease and the global public health agenda: an international consensus

Chronic Kidney Disease of Unknown Etiology (CKDu) – The Search for Causes and the Impact of Its Politicization

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