Seasonal and socioeconomic influences on thyroid function among the Yakut (Sakha) of Eastern Siberia

Lévy, Stéphanie; Leonard, William R.; Tarskaia, Larissa A.; Климова, Т.М.; Федорова, В. И.; Baltakhinova, Marina E.; Krivoshapkin, Vadim G.; Snodgrass, J. Josh

doi:10.1002/ajhb.22457

Cited by 32 publications

(49 citation statements)

References 24 publications

(46 reference statements)

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“…Thyroid hormones are necessary in the adaptation to cold (Leppaluoto et al , 2005Burger 2004). Consistent with previous studies in Antarctica and other circumpolar regions Fig.…”

Section: Discussionsupporting

confidence: 87%

“…2 Comparisons of percent changes in mood between Great Wall Station and Zhongshan Station at mid-winter, end of winter and return to China. *P < 0.05, Great Wall Station versus Zhongshan Station Palinkas et al 2007a;Levy et al 2013), FT4 of the Zhongshan Station crew decreased during the austral winter. Concurrently, TSH levels increased gradually until return to China, where they became statistically significant, suggesting the presence of Polar T3 Syndrome (Sawhney et al 1995;Do et al 2004).…”

Section: Discussionmentioning

confidence: 92%

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Different adaptations of Chinese winter-over expeditioners during prolonged Antarctic and sub-Antarctic residence

Chen

et al. 2016

Int J Biometeorol

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Prolonged residence in Antarctica is characterized by exposure to isolated, confined, and extreme (ICE) environment. Winter-over expeditioners at research stations often exhibit a complex of psychophysiological symptoms, which varied by stations and sociocultural backgrounds. To understand the different patterns of psychophysiological responses provoked by environmental stress, we conducted a longitudinal assessment of mood and endocrine function in two groups of Chinese expeditioners who were deployed to sub-Antarctic (Great Wall Station, 62°S, N = 12) and Antarctic (Zhongshan Station, 66°S, N = 16) from December 2003 to 2005. Measures of mood, thyroid function, the levels of plasma catecholamine, and circulating interleukins were obtained at departure from China, mid-winter (Antarctica), end of winter (Antarctica), and return to China, respectively. The Zhongshan Station crew experienced significant increases in fatigue, anger, tension, confusion, and decrease in free thyroxine (FT4), norepinephrine (NE), and epinephrine (E) during the winter, increase in thyrotropin (TSH) and total triiodothyronine (TT3) when returning, whereas their counterparts at Great Wall Station only experienced increased TT3 after deployment. Moreover, compared with the Great Wall Station crew, the Zhongshan Station crew exhibited greater increase in anger, greater decrease in FT4, total thyroxine (TT4), NE and E over the winter, and greater increase in TSH when returning. Chinese expeditioners who lived and worked at the Antarctic station and the sub-Antarctic station for over a year showed different change patterns in mood and endocrine hormones. Negative mood and endocrine dysfunction were positively associated with the severity of environment. The study is a supplement to scientific knowledge on psychophysiological variation under ICE environment, which has certain applied value for the development of preventive countermeasures or interventions.

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“…Thyroid hormones are necessary in the adaptation to cold (Leppaluoto et al , 2005Burger 2004). Consistent with previous studies in Antarctica and other circumpolar regions Fig.…”

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 92%

Different adaptations of Chinese winter-over expeditioners during prolonged Antarctic and sub-Antarctic residence

Chen

et al. 2016

Int J Biometeorol

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“…Generally, the prohormone T4 formulation is used for therapy because it is thought that the T4 formulation is converted to the T3 formulation in the body [42]. The seasonal change in the metabolic rate between the prohormone T4 and triiodothyronine (T3) is widely recognized, including in humans [4344]. …”

Section: Discussionmentioning

confidence: 99%

Chronobiological Hypothesis about the Association Between Height Growth Seasonality and Geographical Differences in Body Height According to Effective Day Length

Yokoya

Higuchi

2016

J Circadian Rhythms

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Studies on growth hormone therapy in children have shown that height velocity is greater in summer than in winter and that this difference increases with latitude. It is hypothesized that summer daylight is a causative factor and that geographical distribution of body height will approximate the distribution of summer day length over time. This is an ecological analysis of prefecture-level data on the height of Japanese youth. Mesh climatic data of effective day length were collated. While height velocity was greatest during the summer, the height of Japanese youth was strongly and negatively correlated with the distribution of winter effective day length. Therefore, it is anticipated that summer height velocity is greater according to winter day length (dark period). This may be due to epigenetic modifications, involving reversible DNA methylation and thyroid hormone regulation found in the reproductive system of seasonal breeding vertebrates. If the function is applicable to humans, summer height growth may quantitatively increase with winter day length, and height growth seasonality can be explained by thyroid hormone activities that-induced by DNA methylation-change depending on the seasonal difference in day length. Moreover, geographical differences in body height may be caused by geographical differences in effective day length, which could influence melatonin secretion among subjects who spend a significant time indoors.

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“…The severe cold and short day lengths of arctic winters produce a distinctive set of physiological changes known as the polar T3 syndrome (see Reed et al, 1986Reed et al, , 1990aPalinkas and Suedfeld, 2008). Recent work suggests that the wintertime declines in thyroid hormones are greater in indigenous, long-term arctic residents compared to short-term sojourners (Levy et al, 2013), thus providing a mechanism for the significant increases in wintertime BMRs. Recent work suggests that the wintertime declines in thyroid hormones are greater in indigenous, long-term arctic residents compared to short-term sojourners (Levy et al, 2013), thus providing a mechanism for the significant increases in wintertime BMRs.…”

Section: Responses Among Indigenous Arctic Populationsmentioning

confidence: 99%

“…Adapted from Levy et al (2013). These groups are characterized by a pattern known as "Polar T 3 Syndrome"-marked wintertime declines in fT 3 levels associated with tissue update of thyroid hormones exceeding production.…”

Section: Figure 12mentioning

confidence: 99%

Physiological Adaptations to Environmental Stressors

Leonard

2015

Basics in Human Evolution

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Seasonal and socioeconomic influences on thyroid function among the Yakut (Sakha) of Eastern Siberia

Cited by 32 publications

References 24 publications

Different adaptations of Chinese winter-over expeditioners during prolonged Antarctic and sub-Antarctic residence

Different adaptations of Chinese winter-over expeditioners during prolonged Antarctic and sub-Antarctic residence

Chronobiological Hypothesis about the Association Between Height Growth Seasonality and Geographical Differences in Body Height According to Effective Day Length

Physiological Adaptations to Environmental Stressors

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