Seasonal and circadian evaluation of a citral-chemotype from Lippia alba essential oil displaying antibacterial activity

Júnior, Antônio Quaresma da Silva; Silva, Diana S. da; Figueiredo, Pablo Luis B.; Sarrazin, Sandra Layse Ferreira; Bouillet, Leoneide Erica M.; Oliveira, Rodrigo Santos de; Maia, José Guilherme S.; Mourão, Rosa Helena Veras

doi:10.1016/j.bse.2019.05.002

Cited by 22 publications

(13 citation statements)

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“…Another previous study investigated 91 essential oils and found that BCEO exhibited the largest inhibition zone (65.00 mm) against methicillin-resistant Staphylococcus aureus (MRSA), compared with the other EOs that were tested [ 68 ]. Recently, da Silva Júnior et al [ 69 ] found that a citral-chemotype from Lippia alba EO displayed strong antibacterial activity against S. epidermidis with an inhibition zone of >40 mm and MIC at 2.50 µL/mL. A MIC study carried out by Hayes and Markovic [ 70 ] in Australia revealed that BCEO and 100% citral displayed compatible activity against S. aureus , MRSA, E. coli , K. pneumoniae , Pseudomonas aeruginosa , Candida albicans , and Aspergillus niger in the range of 0.05% to 2.00% v/v .…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition, Antioxidant, Antibacterial, and Antibiofilm Activities of Backhousia citriodora Essential Oil

et al. 2022

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The essential oil of Backhousia citriodora, commonly known as lemon myrtle oil, possesses various beneficial properties due to its richness in bioactive compounds. This study aimed to characterize the chemical profile of the essential oil isolated from leaves of Backhousia citriodora (BCEO) and its biological properties, including antioxidant, antibacterial, and antibiofilm activities. Using gas chromatography–mass spectrometry, 21 compounds were identified in BCEO, representing 98.50% of the total oil content. The isomers of citral, geranial (52.13%), and neral (37.65%) were detected as the main constituents. The evaluation of DPPH radical scavenging activity and ferric reducing antioxidant power showed that BCEO exhibited strong antioxidant activity at IC50 of 42.57 μg/mL and EC50 of 20.03 μg/mL, respectively. The antibacterial activity results showed that BCEO exhibited stronger antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis) than against Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae). For the agar disk diffusion method, S. epidermidis was the most sensitive to BCEO with an inhibition zone diameter of 50.17 mm, followed by S. aureus (31.13 mm), E. coli (20.33 mm), and K. pneumoniae (12.67 mm). The results from the microdilution method showed that BCEO exhibited the highest activity against S. epidermidis and S. aureus, with the minimal inhibitory concentration (MIC) value of 6.25 μL/mL. BCEO acts as a potent antibiofilm agent with dual actions, inhibiting (85.10% to 96.44%) and eradicating (70.92% to 90.73%) of the biofilms formed by the four tested bacteria strains, compared with streptomycin (biofilm inhibition, 67.65% to 94.29% and biofilm eradication, 49.97% to 89.73%). This study highlights that BCEO can potentially be a natural antioxidant agent, antibacterial agent, and antibiofilm agent that could be applied in the pharmaceutical and food industries. To the best of the authors’ knowledge, this is the first report, on the antibiofilm activity of BCEO against four common nosocomial pathogens.

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Section: Discussionmentioning

confidence: 99%

Chemical Composition, Antioxidant, Antibacterial, and Antibiofilm Activities of Backhousia citriodora Essential Oil

et al. 2022

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“…Nevertheless, more long-term studies are required to conclusively establish safety. [64] Skin Sensitization: Lippia alba essential oil, similar to many essential oils, has the potential to cause skin sensitization or allergic reactions in some individuals. Recent dermatological studies have reported rare cases of skin irritation, particularly when the oil is used undiluted or in high concentrations.…”

Section: Safety Profile Of Lippia Alba Essential Oilmentioning

confidence: 99%

“…It is advisable for individuals undergoing breast cancer treat- ment to consult healthcare professionals before using essential oils, especially if they are taking medications that may interact with the oil or if they have specific contraindications, such as allergies or respiratory conditions. [67] Pregnancy and Lactation: Caution is recommended for pregnant and breastfeeding individuals when using Lippia alba essential oil. Limited safety data are available for these populations, and it is advisable to seek guidance from healthcare providers regarding the appropriateness of using essential oils during these life stages.…”

Section: Safety Profile Of Lippia Alba Essential Oilmentioning

confidence: 99%

“…Substantial evidence supports the significance of nutrition in breast cancer management, emphasizing the role of specific dietary choices in risk reduction and improved outcomes. [67] For example, a diet rich in fruits, vegetables, whole grains, and lean proteins has been associated with a lower risk of breast cancer recurrence. Conversely, diets high in processed foods, saturated fats, and added sugars may have adverse effects.…”

Section: Exploring the Clinical Evidence Of Lippia Alba Essential Oil...mentioning

confidence: 99%

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Ippia Alba Essential Oil: A Promising Complementary Therapy for Breast Cancer

Hedhili

2024

Chemistry & Biodiversity

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Breast cancer remains a pressing global health issue, spurring exploration into innovative therapies. This review focuses on Lippia alba (Mill.) essential oil's potential as a complementary breast cancer treatment. With growing interest in natural approaches, Lippia alba shows promise in breast cancer management. The review will explore Lippia alba's multifaceted role in treatment, highlighting its anticancer effects on breast cancer cells, potential synergy with conventional treatments, safety profiles, and existing clinical evidence. It will also address knowledge gaps, stressing the need for further research to unlock Lippia alba's full therapeutic potential in breast cancer therapy. In a field craving novel therapies, this review offers a timely analysis. Despite the lack of existing reviews on this topic, Lippia alba's significance cannot be understated. As research progresses, this article will be a valuable resource for researchers and healthcare practitioners seeking to augment breast cancer management through complementary therapies.

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“…Existem diversos estudos que demonstram que os constituintes químicos de OE de uma planta podem variar consideravelmente durante o ciclo dia/noite, pois nesse intervalo de tempo ocorrem flutuações na temperatura, intensidade luminosa e umidade relativa do ar LOPES, 2007;CASTELO et al, 2013;RAPOSO et al, 2018;SILVA-JUNIOR et al, 2019). Em alguns casos o maior rendimento encontrado em OE está no período da tarde (CASTELO et al,2013), no entanto, há plantas que possuem seu pico de rendimento de OE no período da manhã (RAPOSO et al, 2018;SILVA-JUNIOR et al, 2019). Em todo caso, estudos devem ser conduzidos para quantificar a variação causada pela qualidade espectral da radiação solar e, assim, seja possível modular a radiação e estabelecer padrões de cultivos que forneçam OE com alto rendimento e qualidade (GONÇALVES et al, 2003).…”

Section: Espécie Vegetalunclassified

CARACTERIZAÇÃO ANATÔMICA E HISTOQUÍMICA DA LÂMINA FOLIAR DE SIDA rhombifolia L.

Sá¹,

Magalhães²,

Randau³

2020

Avanços Científicos, Tecnológicos E De Inovação Na Botânica

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Seasonal and circadian evaluation of a citral-chemotype from Lippia alba essential oil displaying antibacterial activity

Cited by 22 publications

References 22 publications

Chemical Composition, Antioxidant, Antibacterial, and Antibiofilm Activities of Backhousia citriodora Essential Oil

Chemical Composition, Antioxidant, Antibacterial, and Antibiofilm Activities of Backhousia citriodora Essential Oil

Ippia Alba Essential Oil: A Promising Complementary Therapy for Breast Cancer

CARACTERIZAÇÃO ANATÔMICA E HISTOQUÍMICA DA LÂMINA FOLIAR DE SIDA rhombifolia L.

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