Seasonal and 2009 pandemic influenza A (H1N1) virus infection during pregnancy: a population-based study of hospitalized cases

Creanga, Andreea A.; Kamimoto, Laurie; Newsome, Kimberly; D’Mello, Tiffany; Jamieson, Denise J.; Zotti, Marianne E.; Arnold, Kathryn E.; Baumbach, Joan; Bennett, Nancy M.; Farley, Monica M.; Gershman, Ken; Kirschke, David; Lynfield, Ruth; Meek, James; Morin, Craig; Reingold, Arthur; Ryan, Patricia; Schaffner, William; Thomas, Ann; Zansky, Shelley; Finelli, Lyn; Honein, Margaret A.

doi:10.1016/j.ajog.2011.02.037

Cited by 55 publications

(51 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Physicians' role and barriers 4 and epidemics of seasonal influenza shows 4,5 that pregnant women have been more vulnerable to death due to influenza and its complications than the general population. During the recent 2009 H1N1 pandemic it was shown that pregnant women and their newborns were among the groups at risk for higher rates of hospitalization, intensive care unit (ICU) admission and morbidity or mortality compared with the general population.…”

Section: Acceptance and Rejection Of Influenza Vaccination By Pregnanmentioning

confidence: 99%

Acceptance and rejection of influenza vaccination by pregnant women in southern Iran

Honarvar¹,

Odoomi²,

Mahmoodi³

et al. 2012

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Section: Acceptance and Rejection Of Influenza Vaccination By Pregnanmentioning

confidence: 99%

Acceptance and rejection of influenza vaccination by pregnant women in southern Iran

Honarvar¹,

Odoomi²,

Mahmoodi³

et al. 2012

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

“…Pregnant women with influenza exhibit more severe symptoms and experience higher mortality than do women of the same age in the general population [6]. For pandemic H1N1, the risk of intensive care unit (ICU) admission or death was 7.0 per 100,000 for pregnant women versus 1.7 per 100,000 for non-pregnant women of reproductive age [7].…”

Section: Volume 2 | Issuementioning

confidence: 99%

“…For pandemic H1N1, the risk of intensive care unit (ICU) admission or death was 7.0 per 100,000 for pregnant women versus 1.7 per 100,000 for non-pregnant women of reproductive age [7]. Creanga et al (2011) reported that ICU admissions were more than twice as common in 2009 in pregnant women with H1N1 than among pregnant women during seasonal influenza (11.7% vs. 5.3%) [6]. The Centers for Disease Control and Prevention (CDC) in the USA found 30 (5%) of 593 reported H1N1 deaths through August 2009 were in pregnant women, who account for only about 1% of the general population [8].…”

Section: Volume 2 | Issuementioning

confidence: 99%

Descriptive Study of Exposure to Inhalation Zanamivir and Pregnancy-Related Outcomes

Am¹,

Vannappagari²,

Buus³

et al. 2014

Journal of Pharmaceutics and Drug Development

View full text Add to dashboard Cite

Purpose:To assess the effect of neuraminidase inhibitor (NI), zanamivir, on pregnancy outcomes.Keywords: Influenza; Pregnancy; Drug safety; Zanamivir; Congenital anomalies Abstract ISSN: 2348-9782 Influenza is the most common cause of serious respiratory illness worldwide [1]. In the United States, influenza causes approximately 36,000 deaths and 226,000 hospitalizations in an average season [2]. The 2009 H1N1 influenza pandemic led to greater morbidity and mortality, particularly for those aged less than 65 years. Pandemic influenza affected over 214 countries in 2009 and caused over 18,500 laboratory-confirmed deaths. Globally, there were an estimated 201,200 respiratory deaths (range: 105,700-395,600) with an additional 83,300 cardiovascular deaths (range: 46,000-179,900) associated with 2009 pandemic influenza A H1N1 [3]. Methods:The Health Improvement Network (THIN) provided data from UK General Practitioners (GPs) for 144 pregnant women who were prescribed zanamivir and 144 age-and date-matched untreated comparators with no recorded diagnosis of influenza. Groups were assessed for baseline characteristics, treatment-emergent diagnoses in the mother, pregnancy outcomes and congenital malformations diagnosed in the offspring within 28 days of birth.Results: Treatment and comparator groups were similar at baseline. Most (100/144) zanamivir prescriptions occurred during the second and third trimesters. Groups were similar in recorded smoking during pregnancy; more women in the comparator group had recorded alcohol use. The zanamivir group had more diagnoses compatible with influenza-like illness (ILI) and was more often prescribed antibiotics, analgesics and medicines for respiratory and gastrointestinal symptoms. Pregnancy outcomes other than live birth were not found in the GP record, possibly due in part to cohort entry having occurred late in most pregnancies. There was no difference between groups in the risk of any treatment-emergent diagnosis. Congenital anomalies occurred in similar proportions, but infants born to zanamivir-exposed women had substantially fewer diagnoses from the cluster of cardiac defects consisting of atrial and ventricular septal defects and patent ductus arteriosus (1 zanamivir, 6 comparators).Conclusions: Zanamivir-exposed pregnant women have a wide range of symptoms of and treatments for ILI that complicate comparisons with untreated women. There was no indication of increased risk to the mother, the pregnancy or the infant following exposure. McLean and Pebody (2010) estimated a total of 784,000 (range: 372,000 -1,638,000) clinical cases of influenza-like illness (ILI) due to pandemic H1N1 2009 in England [4]. From the beginning of the pandemic to April 2010, 2,831 patients were hospitalized with confirmed pandemic H1N1 2009 infection. While pregnant women were not at increased risk of influenza infection, once infected, they were five times more likely to be hospitalized (RR 5.1; 95%CI 4.2 -6.1) and seven times more likely to die, in comparison to healthy females of child-b...

show abstract

“…Compared to non-pregnant women, pregnant women had a lower rate of underlying chronic medical conditions [16], which points to pregnancy per se being a high-risk factor. Other significant risk factors for lethal outcome were asthma (22.9% of pregnant women with H1N1 but 43.5% among maternal deaths) obesity (13.0% and 39.1% respectively), white race (22.7% and 44.8% respectively), and more than 4 days lag between initiation of treatment and the onset of symptoms (15.9% and 80% respectively) [5].…”

Section: Pregnancy Outcomes During the 2009 H1n1 Pandemicmentioning

confidence: 99%

Pandemic H1N1 in Pregnancy

Fridman¹,

Minkoff²

2012

Virol Mycol

View full text Add to dashboard Cite

Seasonal and 2009 pandemic influenza A (H1N1) virus infection during pregnancy: a population-based study of hospitalized cases

Cited by 55 publications

References 15 publications

Acceptance and rejection of influenza vaccination by pregnant women in southern Iran

Acceptance and rejection of influenza vaccination by pregnant women in southern Iran

Descriptive Study of Exposure to Inhalation Zanamivir and Pregnancy-Related Outcomes

Pandemic H1N1 in Pregnancy

Contact Info

Product

Resources

About