Season of death and nigral neuronal density in a high‐latitude region

Heiskanen, Lauri; Kivinen, Katri; Gardberg, Maria; Wahlsten, Pia; Kaasinen, Valtteri

doi:10.1111/nan.12496

Cited by 1 publication

(1 citation statement)

References 14 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For eight cases, the measurements were not available and were retrieved from clinical records (median (range) time from recorded body measurements to death was 4.0 (0.9-10.2) years). Nineteen controls (individuals who died without known neurological diseases) were individuals who were examined by forensic pathologists at the Finnish Institute for Health and Welfare, as described [7].…”

Section: Subjects and Clinical Datamentioning

confidence: 99%

Height and nigral neuron density in Parkinson’s disease

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background The dopaminergic system modulates growth hormone secretion and previous results have suggested a link between short stature and an increased risk of Parkinson’s disease (PD). Methods In 36 Lewy body spectrum disease (LBD) cases (PD = 22) and 19 controls, nigral TH-positive neuron densities were measured postmortem from midbrain sections and corrected with the Abercrombie method. Body measurements were collected from autopsies or patient records. Our aim was to investigate the possible relationship between height and the density of neurons in the substantia nigra pars compacta (SNc). Results SNc neuron density (n/mm2) had an inverse association with height, (R2 = 0.317, p < 0.0001) in patients. The association was not explained by weight, age, sex, brain weight, medication, or disease motor severity. The association was also separately observed in patients with PD (n = 22), but not in subjects who died without diagnosed neurological diseases. Conclusions Individual adult height may be connected to nigral neuron numbers in patients with LBDs, including PD.

show abstract

Section: Subjects and Clinical Datamentioning

confidence: 99%