Season of birth and population schizotypy: Results from a large sample of the adult general population

Konrath, Lisa; Beckius, Danièle; Tran, Ulrich S.

doi:10.1016/j.psychres.2016.05.059

Cited by 17 publications

(16 citation statements)

References 42 publications

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“…recently demonstrated a similar excess of winter births in schizotypy among the general population . This study suggested that individuals born in winter might not display a ‘general deficit’ in cognitive functioning, but may show a slight increase in signs of schizophrenia proneness such as schizotypy . Previous findings concerning season of birth effects on cognitive and physical development vs. those on the risk for schizophrenia in the general population suggest that more complex mechanisms should be investigated.…”

Section: Discussionsupporting

confidence: 58%

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The association between season of birth, age at onset, and clozapine use in schizophrenia

Kim

Park

Choi

et al. 2017

Acta Psychiatr Scand

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Section: Discussionsupporting

confidence: 58%

“…However, Konrath et al. recently demonstrated a similar excess of winter births in schizotypy among the general population . This study suggested that individuals born in winter might not display a ‘general deficit’ in cognitive functioning, but may show a slight increase in signs of schizophrenia proneness such as schizotypy .…”

Section: Discussionmentioning

confidence: 65%

The association between season of birth, age at onset, and clozapine use in schizophrenia

Kim

Park

Choi

et al. 2017

Acta Psychiatr Scand

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“…Many reports have found an association of birth season with the occurrence, intensification, and clinical course of mental disorders [ 1 – 3 ]. The etiology of schizophrenia [ 4 , 5 ] and bipolar affective disorder [ 6 ] has been studied most thoroughly so far, and the importance of the virus hypothesis for their development was emphasized [ 7 ]. However, there are few publications that focus on the association between the season of birth the intensification of depressive disorders in children and adults.…”

Section: Introductionmentioning

confidence: 99%

Birth Month and Course of Recurrent Depressive Disorders in a Polish Population

et al. 2018

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BackgroundThe aim of this study was to determine whether the specific season of the year during which the first trimester of pregnancy takes place is significantly associated with the course (intensification and frequency of occurrence) of an episode of recurrent depressive disorder in adult life.Material/MethodsWe enrolled 184 patients treated for recurrent depressive disorders.ResultsAn analysis of the results obtained indicates that the greatest number of people suffering from a major depressive episode were born in the spring and summer (from April to September), meaning that the first trimester of pregnancy occurred between October and March. However, our results were not statistically significant, perhaps due to the small size of the examined group.ConclusionsThe results obtained indicate that birth month may be significantly associated with the course of recurrent depressive disorders. In patients from Central Europe, the first trimester of pregnancy falling in autumn and winter seems to be significant. These results need to be interpreted with caution due to the small size of the examined group.

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“…Both quantitative and molecular genetic studies indicate overlap of schizotypy with schizophrenia at the genetic level supporting the continuum hypothesis [ 16 , 17 , 20 ]. About SOB, findings are mixed [ 21 – 24 ]. While the latest meta-analysis does not indicate an association between winter SOB and schizotypy in adults ( n = 481) [ 25 ], in the largest study to date ( n = 8114), a small, but significant, sex-independent effect of late winter and early spring births on schizotypal traits has been found [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…About SOB, findings are mixed [ 21 – 24 ]. While the latest meta-analysis does not indicate an association between winter SOB and schizotypy in adults ( n = 481) [ 25 ], in the largest study to date ( n = 8114), a small, but significant, sex-independent effect of late winter and early spring births on schizotypal traits has been found [ 24 ]. To our knowledge, no gene X SOB study for schizotypal traits has been published so far.…”

Section: Introductionmentioning

confidence: 99%

Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population

Алфимова

Коровайцева

Лежейко

et al. 2017

Schizophrenia Research and Treatment

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Literature suggests that the effect of winter birth on vulnerability to schizophrenia might be mediated by increased expression of proinflammatory cytokines due to prenatal infection and its inadequate regulation by anti-inflammatory factors. As the response of the immune system depends on genotype, this study assessed the interaction effects of cytokine genes and season of birth (SOB) on schizotypy measured with the Schizotypal Personality Questionnaire (SPQ-74). We searched for associations of IL1B rs16944, IL4 rs2243250, and IL-1RN VNTR polymorphisms, SOB, and their interactions with the SPQ-74 total score in a sample of 278 healthy individuals. A significant effect of the IL4 X SOB interaction was found, p = 0.007 and η2 = 0.028. We confirmed this effect using an extended sample of 373 individuals. Homozygotes CC born in winter showed the highest SPQ total score and differed significantly from winter-born T allele carriers, p = 0.049. This difference was demonstrated for cognitive-perceptual and disorganized but not interpersonal dimensions. The findings are consistent with the hypothesis that the cytokine genes by SOB interaction can influence variability of schizotypal traits in the general population. The IL4 T allele appeared to have a protective effect against the development of positive and disorganized schizotypal traits in winter-born individuals.

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Season of birth and population schizotypy: Results from a large sample of the adult general population

Cited by 17 publications

References 42 publications

The association between season of birth, age at onset, and clozapine use in schizophrenia

The association between season of birth, age at onset, and clozapine use in schizophrenia

Birth Month and Course of Recurrent Depressive Disorders in a Polish Population

Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population

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