Season of birth and Alzheimer's disease: a population-based study in Saguenay-Lac-St-Jean/Québec (IMAGE Project)

Vézina, Hélène; Houde, Louis; Charbonneau, Hubert; Beaudry, Michel; Cholette, A.; Daoud, Nicolas; Mathieu, J.; Robitaille, Yves; Veilleux, Francine; Gauvreau, D.

doi:10.1017/s003329170003378x

Cited by 25 publications

(25 citation statements)

References 24 publications

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“…These include Alzheimer's disease [12,13], subgroups of individuals with attention deficit hyperactivity disorder [14], autism [15][16][17], Down's syndrome [18], dyslexia [19], eating disorders [20] and multiple sclerosis [21].…”

Section: Discussionmentioning

confidence: 99%

Variations in CSF Monoamine Metabolites According to the Season of Birth

Chotai¹,

Åsberg

1999

Neuropsychobiology

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The cerebrospinal fluid (CSF) concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) as well as their ratios and correlations were analyzed in relation to the season of birth. The sample consisted of 241 drug-free patients participating in psychobiological programs and comprising the DSM-III-R diagnoses of mood, anxiety and adjustment disorders. Significant season-of-birth variations were found even after adjusting for sex, age, height, the diagnostic category and the month of lumbar puncture. Those born during February to April had significantly lower values of 5-HIAA. Values of HVA and of the ratios HVA/5-HIAA and HVA/MHPG were significantly higher for those born during October to January. Correlation coefficients also showed season-of-birth variations. These results may provide an important link for the season-of-birth variations reported for several neuropsychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Variations in CSF Monoamine Metabolites According to the Season of Birth

Chotai¹,

Åsberg

1999

Neuropsychobiology

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“…In the Southern Hemisphere, the pattern is shifted by about half a year (10). An excess number of spring births is found among patients suffering from autistic disorders (11), Down's syndrome (12), and Alzheimer's disease (13). In Sweden and Great Britain, spring-born children experience a higher risk of developing insulin-dependent diabetes (14,15).…”

Section: Differences In Adult Lifespan By Month Of Birthmentioning

confidence: 99%

Lifespan depends on month of birth

Doblhammer

Vaupel²

2001

Proc. Natl. Acad. Sci. U.S.A.

372

308

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Month of birth influences adult life expectancy at ages 50؉. Why? In two countries of the Northern Hemisphere-Austria and Denmark-people born in autumn (October-December) live longer than those born in spring (April-June). Data for Australia show that, in the Southern Hemisphere, the pattern is shifted by half a year. The lifespan pattern of British immigrants to Australia is similar to that of Austrians and Danes and significantly different from that of Australians. These findings are based on population data with more than a million observations and little or no selectivity. The differences in lifespan are independent of the seasonal distribution of deaths and the social differences in the seasonal distribution of births. In the Northern Hemisphere, the excess mortality in the first year of life of infants born in spring does not support the explanation of selective infant survival. Instead, remaining life expectancy at age 50 appears to depend on factors that arise in utero or early in infancy and that increase susceptibility to diseases later in life. This result is consistent with the finding that, at the turn of the last century, infants born in autumn had higher birth weights than those born in other seasons. Furthermore, differences in adult lifespan by month of birth decrease over time and are significantly smaller in more recent cohorts, which benefited from substantial improvements in maternal and infant health.

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“…In the Northern Hemisphere, these include studies by Dysken et al [10] in Minnesota (n = 727, autopsy confirmed); Vitiello et al [11] in Maryland (n = 150); Lawlor et al [12] in Ireland (n = 215); Fratiglioni et al [13] in Sweden (n = 98); Prince et al [14] in England (n = 31), and Vézina et al [15] in Canada (n = 399). In the Southern Hemisphere, Henderson et al [16] reported no significant seasonal birth pattern for 170 individuals with Alzheimer's disease, including 143 who had been born in the Southern Hemisphere.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Seasonal Birth Patterns of Neurological Disorders

et al. 2000

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Existing seasonal birth studies were reviewed for multiple sclerosis (MS), Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), epilepsy, cerebral palsy, congenital malformations of the central nervous system and mental retardation. Epilepsy appears to have the most consistent pattern, with an excess of births in winter and a deficit in September. MS, ALS and possibly Parkinson’s disease appear to have an excess of spring births. Studies of cerebral palsy are not conclusive, although there are suggestions that there may be an excess of summer births. The findings for Alzheimer’s disease, congenital malformations of the central nervous system, and mental retardation are contradictory and insufficient to draw any conclusions.

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Season of birth and Alzheimer's disease: a population-based study in Saguenay-Lac-St-Jean/Québec (IMAGE Project)

Cited by 25 publications

References 24 publications

Variations in CSF Monoamine Metabolites According to the Season of Birth

Variations in CSF Monoamine Metabolites According to the Season of Birth

Lifespan depends on month of birth

Seasonal Birth Patterns of Neurological Disorders

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