Searching Literature Databases for Health Care Economic Evaluations

Sassi, Franco; Archard, Luke; McDaid, David

doi:10.1097/00005650-200205000-00004

Cited by 67 publications

(62 citation statements)

References 9 publications

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“…15 However, the methodologic standards for clinical topics are generally much higher, so that the literature retrieved provides more robust answers. 18 which are designed to retrieve economic evaluation articles, were compared with one another, to generate a relative standard, giving estimates of sensitivity of 72% and specificity of 75% for the LSE strategy in MEDLINE. 18 Our findings for economics articles appear to be somewhat better but are not directly comparable, as our gold standard was a hand search.…”

Section: Discussionmentioning

confidence: 99%

“…18 which are designed to retrieve economic evaluation articles, were compared with one another, to generate a relative standard, giving estimates of sensitivity of 72% and specificity of 75% for the LSE strategy in MEDLINE. 18 Our findings for economics articles appear to be somewhat better but are not directly comparable, as our gold standard was a hand search. Additional filters have been designed to retrieve articles on outcome measurement 19 (just 3 strategies based on hand searches in Table 5 for denominators used to calculate sensitivity, specificity and precision.…”

Section: Discussionmentioning

confidence: 99%

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Optimal search strategies for detecting health services research studies in MEDLINE

Wilczynski

Haynes²,

Lavis³

et al. 2004

Canadian Medical Association Journal

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W ith the increasing emphasis on "using evidence" and "value for money" in health services, it is essential that researchers, clinicians, health system managers and public policy-makers be able to retrieve relevant, high-quality reports of health services research (HSR). Efficiently retrieved research evidence can aid in decisionmaking about which services to provide and in the resource allocation decisions to support those services, reducing the need for arbitrary decisions and aiding collaboration with clinicians and consumers.1 MEDLINE is a huge and expanding bibliographic resource that is freely available to all with Internet access. Yet the volume of the literature often overwhelms both clinicians and health system decisionmakers. 2,3 End-users of MEDLINE and other large bibliographic databases have difficulty executing precise searches 2,3 and are often unaware of what kind of information to seek, where to find it 3,4 and how to judge its quality. 3HSR has been defined as the scientific study of the effect of health care delivery; the organization and management of health care access, quality, cost and financing; and the evaluation of the impact of health services and technology (Allmang NA, Koonce TY. Health services research topic searches. Bethesda [MD]: National Library of Medicine; 2000. Unpublished report). More recently, HSR has been defined as the multidisciplinary field of scientific investigation that studies how social factors, financing systems, organizational structures and processes, health technologies and personal behaviours affect access to health care, the quality and cost of health care and, ultimately, health and well-being.5 HSR articles constitute only a tiny fraction of the MEDLINE database and are spread through a large number of journals; hence, MEDLINE searching is challenging. Conversely, journal browsing is impractical as a means of retrieving all relevant studies for a given question or staying abreast of the literature. Our aim was to develop methodologic search filters for MEDLINE to enable endusers to efficiently retrieve articles of relevance to clinical practice guidelines (CPGs) and the appropriateness, process, outcomes, cost and economics of health services. MethodsWe compared the retrieval performance of methodologic search terms and phrases in MEDLINE with a manual review of each article in each issue of 68 journal titles for the year 2000 for the study categories of appropriateness, process assessment, outcome assessment, CPGs, cost and economics of care. Search termsCandidate content and methodologic terms (text words and Medical Subject Headings [MeSH] [exploded and nonexploded], publication types) were compiled by reviewing "gold standard" articles and their MEDLINE indexing, the definitions in Table 1 and the criteria in Table 2; by consulting experts in bibliographic database searching for HSR topics (mainly health sciences librari- rently thinly spread through many journals, making it difficult for health services researchers, managers and policy-makers to fin...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Optimal search strategies for detecting health services research studies in MEDLINE

Wilczynski

Haynes²,

Lavis³

et al. 2004

Canadian Medical Association Journal

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“…The main sources for identifying full EEs are general databases (or basic databases), such as Medline (freely accessible on the Internet through PubMed) [44,45], Embase [45], Econlit, and Web of Science. The two databases specifically developed for EEs of health-care interventions, the NHS EED and the HEED, are no longer publishing; NHS EED can be used for searches of full EEs up to March 2015, but HEED is no longer accessible.…”

Section: Step 21: Select Relevant Data Sourcesmentioning

confidence: 99%

“…and specificity in relation to the aims of the SR [11,44]. In general, a successful search strategy is regarded as one that delivers a manageable amount of references with a searcherspecified balance of sensitivity and precision [51].…”

Section: Designmentioning

confidence: 99%

How to prepare a systematic review of economic evaluations for informing evidence-based healthcare decisions: a five-step approach (part 1/3)

Mastrigt

Hiligsmann

Arts

et al. 2016

Expert Review of Pharmacoeconomics & Outcomes Research

152

159

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Introduction: Systematic reviews of economic evaluations are useful for synthesizing economic evidence about health interventions and for informing evidence-based decisions. Areas covered: As there is no detailed description of the methods for performing a systematic review of economic evidence, this paper aims to provide an overview of state-of-the-art methodology. This is laid out in a 5-step approach, as follows: step 1) initiating a systematic review; step 2) identifying (full) economic evaluations; step 3) data extraction, risk of bias and transferability assessment; step 4) reporting results; step 5) discussion and interpretation of findings. Expert commentary: The paper aims to help inexperienced reviewers and clinical practice guideline developers, but also to be a resource for experts in the field who want to check on current methodological developments. ARTICLE HISTORY

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“…With the cost data in mind, the searches were run in the following databases: MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, EMBASE, CINAHL, The Cochrane Library (all), Web of Science (including conference proceedings) and EconLit. 279,280 The filters used were the NHS EED search filter supplemented by the NHS Quality Improvement filter (brief). 281 The above databases were also searched for guidelines information, as were the British Nursing Index (BNI) and HMIC; however, the latter returned nil results.…”

Section: Costs Associated With Colorectal Cancermentioning

confidence: 99%

A systematic review and economic evaluation of diagnostic strategies for Lynch syndrome

Snowsill

Huxley

Hoyle

et al. 2014

Health Technology Assessment

106

234

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BackgroundLynch syndrome (LS) is an inherited autosomal dominant disorder characterised by an increased risk of colorectal cancer (CRC) and other cancers, and caused by mutations in the deoxyribonucleic acid (DNA) mismatch repair genes.ObjectiveTo evaluate the accuracy and cost-effectiveness of strategies to identify LS in newly diagnosed early-onset CRC patients (aged < 50 years). Cascade testing of relatives is employed in all strategies for individuals in whom LS is identified.Data sources and methodsSystematic reviews were conducted of the test accuracy of microsatellite instability (MSI) testing or immunohistochemistry (IHC) in individuals with CRC at risk of LS, and of economic evidence relating to diagnostic strategies for LS. Reviews were carried out in April 2012 (test accuracy); and in February 2012, repeated in February 2013 (economic evaluations). Databases searched included MEDLINE (1946 to April week 3, 2012), EMBASE (1980 to week 17, 2012) and Web of Science (inception to 30 April 2012), and risk of bias for test accuracy was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) quality appraisal tool. A de novo economic model of diagnostic strategies for LS was developed.ResultsInconsistencies in study designs precluded pooling of diagnostic test accuracy results from a previous systematic review and nine subsequent primary studies. These were of mixed quality, with significant methodological concerns identified for most. IHC and MSI can both play a part in diagnosing LS but neither is gold standard. No UK studies evaluated the cost-effectiveness of diagnosing and managing LS, although studies from other countries generally found some strategies to be cost-effective compared with no testing.The de novo model demonstrated that all strategies were cost-effective compared with no testing at a threshold of £20,000 per quality-adjusted life-year (QALY), with the most cost-effective strategy utilising MSI andBRAFtesting [incremental cost-effectiveness ratio (ICER) = £5491 per QALY]. The maximum health benefit to the population of interest would be obtained using universal germline testing, but this would not be a cost-effective use of NHS resources compared with the next best strategy. When the age limit was raised from 50 to 60 and 70 years, the ICERs compared with no testing increased but remained below £20,000 per QALY (except for universal germline testing with an age limit of 70 years). The total net health benefit increased with the age limit as more individuals with LS were identified. Uncertainty was evaluated through univariate sensitivity analyses, which suggested that the parameters substantially affecting cost-effectiveness: were the risk of CRC for individuals with LS; the average number of relatives identified per index patient; the effectiveness of colonoscopy in preventing metachronous CRC; the cost of colonoscopy; the duration of the psychological impact of genetic testing on health-related quality of life (HRQoL); and the impact of prophylactic hysterectomy and bilateral salpingo-oophorectomy on HRQoL (this had the potential to make all testing strategies more expensive and less effective than no testing).LimitationsThe absence of high-quality data for the impact of prophylactic gynaecological surgery and the psychological impact of genetic testing on HRQoL is an acknowledged limitation.ConclusionsResults suggest that reflex testing for LS in newly diagnosed CRC patients aged < 50 years is cost-effective. Such testing may also be cost-effective in newly diagnosed CRC patients aged < 60 or < 70 years. Results are subject to uncertainty due to a number of parameters, for some of which good estimates were not identified. We recommend future research to estimate the cost-effectiveness of testing for LS in individuals with newly diagnosed endometrial or ovarian cancer, and the inclusion of aspirin chemoprevention. Further research is required to accurately estimate the impact of interventions on HRQoL.Study registrationThis study is registered as PROSPERO CRD42012002436.FundingThe National Institute for Health Research Health Technology Assessment programme.

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Searching Literature Databases for Health Care Economic Evaluations

Cited by 67 publications

References 9 publications

Optimal search strategies for detecting health services research studies in MEDLINE

Optimal search strategies for detecting health services research studies in MEDLINE

How to prepare a systematic review of economic evaluations for informing evidence-based healthcare decisions: a five-step approach (part 1/3)

A systematic review and economic evaluation of diagnostic strategies for Lynch syndrome

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