Searching for female reproductive aging and longevity biomarkers

Yureneva, S. V.; Averkova, V.G.; Silachev, Denis N.; Donnikov, Donnikov A.E.; Gavisova, Alla; Serov, V N; Сухих, Г. Т.

doi:10.18632/aging.203206

Cited by 19 publications

(21 citation statements)

References 158 publications

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“…Reproductive life span of women (age at natural menopause (ANM)) remains constant (50-52 years). A later age at ANM is associated with a higher risk of cardiovascular and other reproductive aging-associated chronic diseases (Yureneva et al, 2021). Women′s fecundity starts to decline gradually after the mid-20s and becomes more pronounced after 35 years of age (Ahmed et al, 2020;Broekmans et al, 2009;Kasapoğlu and Seli, 2020).…”

Section: Reproductive System Agingmentioning

confidence: 99%

Biomarkers of aging

Bao

Cao

Chen

et al. 2023

Sci. China Life Sci.

117

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Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars: physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant. Supporting Information The supporting information is available online at 10.1007/s11427-023-2305-0. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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Section: Reproductive System Agingmentioning

confidence: 99%

Biomarkers of aging

Bao

Cao

Chen

et al. 2023

Sci. China Life Sci.

117

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“… 14 In addition, among women with exclusive breastfeeding, a longer breastfeeding history might prevent peripheral nerve aging by slowing the return of ovulation after delivery and reproductive aging. 29 …”

Section: Discussionmentioning

confidence: 99%

Association Between Breastfeeding and Reduced Distal Sensory Polyneuropathy in Postmenopausal Women Aged 40–70 Years: Analysis of Data from the 1999–2004 National Health and Nutrition Examination Survey

Santibenchakul

Chongpison

et al. 2023

Breastfeeding Medicine

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Background: Distal sensory polyneuropathy (DSP) is a common peripheral neuropathy subtype. We aimed to determine the association between breastfeeding and DSP among postmenopausal women aged 40–70 years, and the effect modification of obesity on this association. Methods: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey 1999–2004. Postmenopausal women aged 40–70 years were included. Women with diabetes, stroke, cancer, cardiovascular disease, thyroid disease, liver disease, weak/failing kidneys, or amputation were excluded. Binary logistic regression was used to analyze the association between breastfeeding and DSP. Results: Among 798 participants, 386 (44.30%) reported breastfeeding history and 51 (5.29%) were defined as having DSP using the monofilament test. A significant inverse association was observed between breastfeeding and DSP (odds ratio [OR] = 0.29; 95% confidence interval [CI]: 0.11–0.79; p = 0.017) after adjusting for other confounding variables. In subgroup analysis, this adjusted association was observed only in the obese group (OR = 0.21; 95% CI: 0.06–0.73, p = 0.013). Conclusions: Breastfeeding was found to have potential benefits in the presence of DSP in postmenopausal women aged 40–70 years, and obesity modified the association between breastfeeding and DSP. Promoting breastfeeding may reduce the burden of peripheral neuropathy in middle-aged postmenopausal women.

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“…Female fertility is negatively affected by premature ovarian failure due to insufficient egg numbers and poor egg quality [ 16 ]. A few low-quality eggs can markedly reduce the fertility rate of women in two ways: lowered fertility, or in cases of pregnancy, miscarriages usually occur.…”

Section: Premature Ovarian Insufficiency or Agingmentioning

confidence: 99%

“…Reproductive aging, which mostly develops over time, is a natural phenomenon [ 15 ]. Several studies have revealed the complexity and serendipitous uncertainty of the interconnectedness between reproductive aging and other organ aging [ 16 ]. Recently, numerous studies have described a strong connotation amongst inflammatory aging and POI [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Stem Cell-Based Therapeutic Strategies for Premature Ovarian Insufficiency and Infertility: A Focus on Aging

Ali

Padhiar

Wang

et al. 2022

Cells

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Reproductive aging is on the rise globally and inseparable from the entire aging process. An extreme form of reproductive aging is premature ovarian insufficiency (POI), which to date has mostly been of idiopathic etiology, thus hampering further clinical applications and associated with enormous socioeconomic and personal costs. In the field of reproduction, the important functional role of inflammation-induced ovarian deterioration and therapeutic strategies to prevent ovarian aging and increase its function are current research hotspots. This review discusses the general pathophysiology and relative causes of POI and comprehensively describes the association between the aging features of POI and infertility. Next, various preclinical studies of stem cell therapies with potential for POI treatment and their molecular mechanisms are described, with particular emphasis on the use of human induced pluripotent stem cell (hiPSC) technology in the current scenario. Finally, the progress made in the development of hiPSC technology as a POI research tool for engineering more mature and functional organoids suitable as an alternative therapy to restore infertility provides new insights into therapeutic vulnerability, and perspectives on this exciting research on stem cells and the derived exosomes towards more effective POI diagnosis and treatment are also discussed.

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Searching for female reproductive aging and longevity biomarkers

Cited by 19 publications

References 158 publications

Biomarkers of aging

Biomarkers of aging

Association Between Breastfeeding and Reduced Distal Sensory Polyneuropathy in Postmenopausal Women Aged 40–70 Years: Analysis of Data from the 1999–2004 National Health and Nutrition Examination Survey

Stem Cell-Based Therapeutic Strategies for Premature Ovarian Insufficiency and Infertility: A Focus on Aging

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