Searching for Evidence of Transfer between Drug Facilitators

Miller, Mark A.; Parker, B. Kent; Keely, Josue P.; Johnson, Jennifer L.; Schaal, David W.

doi:10.1006/lmot.2001.1095

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…Although we will delay further discussion of this point until the concluding comments, we should note that despite some evidence to the contrary (M. A. Miller, Parker, Keely, Johnson, & Schaal, 2002), we were not surprised to fi nd transfer of conditional control by drug contexts. Indeed, recent associative learning theories place tremendous emphasis on the modulatory infl uence of discrete and contextual cues in Pavlovian conditioning (e.g., Bouton, 1993Bouton, , 2002Kasprow, Schachtman, & Miller, 1987;Rescorla, 1986;Schmajuk, Lamoureux, & Holland, 1998).…”

Section: Occasion Settingmentioning

confidence: 90%

Extending the Role of Associative Learning Processes in Nicotine Addiction

Bevins

Palmatier

2004

Behavioral and Cognitive Neuroscience Reviews

107

119

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Compulsive smoking is a worldwide public health problem. Although research has confirmed the importance of associative learning processes in nicotine addiction, therapies targeting nicotine-associated cues still have a high relapse rate. Most theories conceptualize nicotine as an ‘outcome’ that reinforces behaviors and/or changes the affective value of stimuli. Albeit important, this view does not capture the complexity of associative processes involved in nicotine addiction. For example, nicotine serves as a conditional stimulus acquiring new appetitive/affective properties when paired with a non-drug reward. Also, nicotine functions as an occasion setter that participates in higher-order associative processes that likely permit a more pervasive influence of conditioned cues that are resistant to typically cue-exposure therapy techniques. Finally, nicotine appears to amplify the salience of other stimuli that have some incentive value resulting in enhanced nicotine selfadministration and conditioned reinforcement processes. Future smoking intervention strategies should take into consideration these additional associative learning processes.

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Section: Occasion Settingmentioning

confidence: 90%

Extending the Role of Associative Learning Processes in Nicotine Addiction

Bevins

Palmatier

2004

Behavioral and Cognitive Neuroscience Reviews

107

119

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“…The pharmacological effects of a drug can also function as an interoceptive contextual stimulus that can be used to disambiguate a Pavlovian association (Holland, 1989;Parker et al, 1994;Miller et al, 2002;Palmatier et al, 2004Palmatier et al, , 2005Troisi and Akins, 2004;Bevins et al, 2006). In such a procedure, the drug state is considered a positive feature when it signals or 'sets the occasion' upon which the conditioned stimulus (CS) is reinforced.…”

Section: Introductionmentioning

confidence: 98%

Methamphetamine functions as a positive and negative drug feature in a Pavlovian appetitive discrimination task

Reichel

Wilkinson

Bevins

2007

Behavioural Pharmacology

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This research determined the ability of methamphetamine to serve as a positive or negative feature, and assessed the ability of bupropion, cocaine, and naloxone to substitute for the methamphetamine features. Rats received methamphetamine (0.5 mg/kg, intraperitoneally) or saline 15 min before a conditioning session. For the feature positive (FP) group, offset of 15-s cue lights was followed by access to sucrose on methamphetamine sessions; sucrose was withheld during saline sessions. For the feature negative (FN) group, the light offset was followed by sucrose on saline sessions; sucrose was withheld during methamphetamine sessions. During acquisition, the FP group had higher responding on methamphetamine sessions than on saline sessions. For the FN group, responding was higher on saline sessions than on methamphetamine sessions. Conditioned responding was sensitive to methamphetamine dose. For the FP group, bupropion and cocaine fully and partially substituted for methamphetamine, respectively. In contrast, both drugs fully substituted for methamphetamine in the FN group. Naloxone did not substitute in either set of rats. FP-trained rats were more sensitive to the locomotor stimulating effects of the test drugs than FN-trained rats. This research demonstrates that the pharmacological effects of methamphetamine function as a FP or FN in this Pavlovian discrimination task and that training history can affect conditioned responding and locomotor effects evoked by a drug.

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“…Differential control by the CS of head entries into the dipper, hereafter termed goal tracking, is a widely used measure of Pavlovian conditioned responding (Bouton and Sunsay 2003;Delamater 1995;Rescorla 1999) and refers to a rat's tendency to search places where rewards have occurred (Boakes 1977;Farwell and Ayres 1979). The light CS evoked more goal tracking in the nicotine state than the saline state, indicating that nicotine served as a positive feature [see Parker et al 1994 andMiller et al 2002 for examples of Pavlovian drug discriminations using pigeon sign tracking (autoshaping) with methadone or phencyclidine as a drug feature].…”

Section: Introductionmentioning

confidence: 99%