Searching for Celiac Disease in Pediatric General Practice

Ventura, Alessandro; Facchini, Sergio; Amantidu, C.; Andreotti, M; Andrighetto, A.; Baggiani, Angelo; Benedetti, Fabio; Bonati, S.; Buonaterra, I.; Capozzo, Maria Anna; Ciscato, E.; Cracco, Francesco; Fornalè, M; Fusco, Flavia; Laverda, E.; Mardiciaro, M.; Nicolussi, E.; Pasinato, Luca; Pittarello, Demetrio; Pizio, E.; Salvadori, R.; Sambugaro, D.; S, Sassolino; Spavanello, V.; Visan, C. T.; Ziglio, G; Zuffellato, V.

doi:10.1177/000992280104001008

Cited by 10 publications

(7 citation statements)

References 7 publications

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“…The other 21 were asymptomatic, confirming that gastrointestinal complaints are present only in a minority of CD subjects. Recent clinical and epidemiological studies in children 17 and adults 18 confirm our findings and show that if CD is suspected only in the presence of gastrointestinal symptoms, many cases are bound to pass undiagnosed.…”

Section: Discussionsupporting

confidence: 84%

Mass screening for coeliac disease using antihuman transglutaminase antibody assay

Tommasini

2004

Archives of Disease in Childhood

187

121

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Section: Discussionsupporting

confidence: 84%

Mass screening for coeliac disease using antihuman transglutaminase antibody assay

Tommasini

2004

Archives of Disease in Childhood

187

121

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“…Other authors proposed questionnaires with extended questions regarding associated diseases (some autoimmune diseases, syndromes, IgA deficiency, anaemia, etc. [79]) and the family history (CD in a first-degree relative [77-79]). This questionnaire design clarifies the detection of the percentage of CD cases, since it is known that the frequency of CD is higher in groups of children with extraintestinal CD manifestations and associated conditions.…”

Section: Questionnaire-based Survey As An Auxiliary Tool For Finding mentioning

confidence: 99%

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Savvateeva

Erdes

Antishin

et al. 2018

Int Arch Allergy Immunol

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Coeliac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten-containing grains in genetically predisposed individuals. Identification of CD in clinical practice is often difficult due to the manifestation of non-specific symptoms and signs, so a relatively significant proportion of CD cases remain undiagnosed. Timely detection of the disease is necessary to provide an appropriate approach to control of the disease treatment, in order to avoid potential complications. This is even more important in the case of children and adolescents, to ensure their proper growth and development. In this review, we discuss the data on the current strategies for CD detection among paediatric populations and the role of questionnaire-based discovery of CD cases in the area of interest. We assume that mass screening is a preferable strategy for finding CD cases within the paediatric population because this could uncover symptomatic, oligosymptomatic, and asymptomatic CD cases. However, under conditions of limited financial resources, screening for CD in risk groups, members of which can be identified using questionnaires, is essential. The pros and cons of CD screening in paediatric populations are presented. These depend on a number of situational criteria (cost-effectiveness, lack of awareness), but screening is designed to improve the detection of the disease and therefore improve the quality of life of patients.

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“…In our experience, both of these groups have very high concentrations of specific IgG autoantibodies. Because case-finding screening programs can now be set up for children (18 ) and adults (19 ) at risk for undiagnosed CD, the accurate determination of age-related cutoff limits is crucial (20 ). With this in mind (and to avoid false-positive test results, which may lead to unnecessary intestinal biopsies), highly specific tests are essential.…”

Section: Anti-transglutaminase Antibodies and Age Valentinamentioning

confidence: 99%