Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin II type 1 receptor and angiotensinogen gene polymorphisms

Fatini, Cinzia; Abbate, Rosanna; Pepe, Guglielmina; Battaglini, B; Gensini, Francesca; Ruggiano, G; Gensini, G. F.; Guazzelli, R

doi:10.1053/euhj.1999.1738

Cited by 90 publications

(77 citation statements)

References 23 publications

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“…27,28 The D allele was recognized as being associated with high ACE activity in plasma, increased blood pressure and increased risk of plaque rupture in many different populations. 29,30 Our results are consistent with these findings according to which the presence of ACE D/D genotype may modify the myocardial perfusion promoting an increase of cardiovascular events. These findings show the importance of studying ACE polymorphism in correlation to myocardial perfusion values.…”

Section: Discussionsupporting

confidence: 91%

Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging

et al. 2009

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Coronary artery disease is associated with multiple genetic and environmental risk factors. In this study, we evaluated the correlation of angiotensin l-converting enzyme (ACE) (I/D) and ApoE gene polymorphisms (E2, E3, E4 and g.-219G/T) with myocardial perfusion. We examined 410 patients using exercise-rest myocardial perfusion single photon emission computed tomography (SPECT), in which the summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS) indexes were calculated. Homozygotes for the ACE D allele had greater mean values of SSS (Po0.001) and SDS (Po0.001). In addition, E3 homozygotes, E4 heterozygotes and E4 homozygotes had significantly higher values of SSS and SDS compared with E3 heterozygotes (Po0.001); E4 homozygotes had significantly higher values of SSS and SDS compared with E3 homozygotes. Furthermore, for the g.-219G4T polymorphic site at the promoter region of ApoE gene, the mean values of SSS and SDS were significantly higher for T heterozygotes/homozygotes than for GG homozygotes. Adjusting for all demographic and clinical data using multiple linear regression analysis it was found that ACE D and both ApoE genotypes were independent predictors with a cumulative contribution for the prediction of SSS and SDS. Furthermore, logistic regression analysis revealed that all three genotypes had an independent predictive ability for abnormal SSS (SSS42). These data provide the first evidence of an association and significant cumulative contribution of the aforementioned genotypes in myocardial perfusion with E4 allele having the strongest association followed by ACE D and ApoE g.-219T alleles.

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Section: Discussionsupporting

confidence: 91%

Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging

et al. 2009

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“…For example, the combination of 19 and the ACE DD genotype plus the A1166C polymorphism is associated with the high blood pressure values in healthy subjects 20 and the presence of coronary artery disease in the general population. 21 The effects of gender, age, race or obesity on the distribution of polymorphisms and their effect on blood pressure response was also unexplored. Evidence is accumulating that some RAS gene polymorphisms may assume importance in the context of specific demographic traits, but the relationships are complex.…”

Section: Discussionmentioning

confidence: 99%

Renin–angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients

et al. 2004

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This study analyzed the relationship between four renin-angiotensin system (RAS) gene polymorphisms and the response to blood pressure lowering and development of microalbuminuria in 206 patients with essential hypertension treated once daily for 12 months with telmisartan 80 mg. Seated cuff blood pressure and urinary albumin excretion (UAE) were measured throughout the study. Patients were screened for the presence of the A-6G variant of the angiotensinogen gene, angiotensin-converting enzyme insertion/deletion polymorphism, and the A1166C and C573T polymorphisms of the angiotensin II type 1 receptor gene. No significant association was found between the presence of any gene polymorphism and the reduction of blood or UAE following telmisartan treatment. The results indicate that these RAS gene polymorphisms do not affect the antihypertensive activity and renoprotection in mild-to-moderate hypertensive patients treated with telmisartan.

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“…The AGT1RA1166C CC genotype is associated with greater ANG II responsiveness [7] and 56 increases risk for coronary artery disease and myocardial infarction [8] compared with the 57 AA genotype. AGT2R C4599A (rs11091046), AGT2R A1675G (rs1403543) and AGT2R 58 T1134C (rs12710567) are located in the 3' UTR of exon 3, intron 1 and the promoter region 59 of the AGT2R gene on the X chromosome, respectively.…”

Section: Introduction: 40mentioning

confidence: 99%

The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI

et al. 2013

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The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI Placenta, 2013; 34(1):75-81 © 2012 Elsevier Ltd. All rights reserved. NOTICE: this is the author's version of a work that was accepted for publication in Placenta.Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Placenta, 2013; 34(1) Elsevier's AAM Policy: Authors retain the right to use the accepted author manuscript for personal use, internal institutional use and for permitted scholarly posting provided that these are not for purposes of commercial use or systematic distribution.Elsevier believes that individual authors should be able to distribute their AAMs for their personal voluntary needs and interests, e.g. posting to their websites or their institution's repository, e-mailing to colleagues. However, our policies differ regarding the systematic aggregation or distribution of AAMs to ensure the sustainability of the journals to which AAMs are submitted. Therefore, deposit in, or posting to, subjectoriented or centralized repositories (such as PubMed Central), or institutional repositories with systematic posting mandates is permitted only under specific agreements between Elsevier and the repository, agency or institution, and only consistent with the publisher's policies concerning such repositories. This study aimed to determine the association of AGT1R and AGT2R polymorphisms with 18 preeclampsia and whether these are affected by environmental factors and fetal sex. Overall 19 3234 healthy nulliparous women, their partners and babies were recruited prospectively to the 20 SCOPE study in Adelaide and Auckland. Data analyses were confined to 2121 Caucasian 21 parent-infant trios, among whom 123 had preeclamptic pregnancies. 1185 uncomplicated 22 pregnancies served as controls. DNA was extracted from buffy coats and genotyped by 23 utilizing the Sequenom MassARRAY system. Doppler sonography on the uterine arteries was 24 performed at 20 weeks' gestation. When the cohort was stratified by maternal BMI, in 25 women with BMI≥25kg/m 2 , the AGT2R C4599A AA genotype in mothers and neonates was 26 associated with an increased risk for preeclampsia compared with the CC genotype [OR 2.1 27 (95% CI 1.0-4.2) and OR 3.0 (95% CI 1.4-6.5), respectively]. In the same subset of women, 28 paternal AGT2R C4599A A allele was associated with an increased risk for preeclampsia and 29 uterine artery bilateral notching at 20 weeks' gestation compared with the C allele [OR 1.9 30 (95% CI 1.1-3.2) and OR 2.1 (95% CI 1.3-3.4), respectively]. AGT2R C4599A in mothers, 31 fathers and babies was associated with preeclampsia and this association was only apparent in 32 pregnancies in which the women had a BMI≥25kg/m 2 , suggesting a gene-environm...

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Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin II type 1 receptor and angiotensinogen gene polymorphisms

Abstract: Our report indicates the increased risk of coronary artery disease in the presence of ACE DD and AT1R CC genotypes independent of other risk factors, in Italian patients. The present study stresses the relevance of screening for genetic risk factors.

Cited by 90 publications

References 23 publications

Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging

Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging

Renin–angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients

The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI

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