2024
DOI: 10.3390/jpm14050513
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Searching for a Better Animal Model for Chronic Tympanic Membrane Perforation

Dragoș Bularda,
Roxana Șerban,
Corina Butnaru
et al.

Abstract: Chronic tympanic membrane perforation represents a prevalent otological condition, necessitating a reliable animal model for the validation and safety assessment of surgical techniques and materials employed in myringoplasty. This prospective study involved the establishment of chronic tympanic membrane perforation animal models in 16 chinchillas. A thermic myringotomy was conducted on the right ear (study group), followed by cold instrument myringotomy, coupled with the topical application of mitomycin C and … Show more

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