Search for W′ signal in single top quark production at the LHC

Huang, Fei; Si, Zong-Guo; Li, Honglei; Yang, Z.; Li, Shi‐Yuan; Su, Wei

doi:10.1088/1674-1137/42/3/033103

Cited by 6 publications

(10 citation statements)

References 42 publications

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“…An analogous Endo-A mutant, Endo-A N171A, was also created, which could transglycosylate Man9GlcNAc oxazoline effectively. 60 Kinetic studies revealed that the dramatically enhanced synthetic efficiency of the Endo-A N171A mutant over the wild-type Endo-A was due to its significantly reduced hydrolytic activity toward both the Man9GlcNAc oxazoline and the product, as well as to its enhanced activity for transglycosylation. Extension of the chemoenzymatic method to the synthesis of homogeneous glycoforms of ribonuclease B carrying full-size natural N-glycans was achieved (Scheme 9).…”

Section: Generation Of Engase-based Glycosynthases For Transglycosylamentioning

confidence: 99%

“…Moreover, the invention of glycosynthases, a class of novel glycosidase mutants that are devoid of hydrolytic activity but are capable of using a suitable activated glycosyl donor for transglycosylation, provides a beautiful solution to the two fundamental problems associated with glycosidase-catalyzed synthesis: the low transglycosylation efficiency and product hydrolysis. 32,[57][58][59][60][61][62][63][64] On the other hand, recent advances have shown that both glycosyltransferases and glycosidases can in fact have relaxed substrate specificity, allowing the synthesis of both natural and selectively modified complex carbohydrates. 25,56 In this chapter, we highlight recent advances in the use of endoglycosidases for the synthesis of biologically interesting glycans and glycoconjugates, including natural and artificial polysaccharides, glycoproteins, and glycolipids.…”

Section: Enzymes As a Tool For The Synthesis Of Glycans And Glycoconjmentioning

confidence: 99%

“…Recently, an endo chitinase from Serratia proteamaculans was reported to possess hyper transglycosylation activity to synthesize long-chain chitooligosaccharides. 105 Following the glycosynthase concept proposed for endo-β-N-acetylglucosaminidases that use a substrate-assisted mechanism via the formation of a sugar oxazolinium ion intermediate, 59,60,106 glycosynthase mutants were also generated from chitinases by sitedirected mutagenesis of the key residue that promotes sugar oxazolinium ion formation during hydrolysis. Cottaz and coworkers reported that mutation of the D202 residue in the chitinase A1 from Bacillus circulans gave a mutant (D202A) that could significantly diminish the hydrolytic activity and increase the yield of sugar oxazoline polymerization.…”

Section: Chitinase-catalyzed Synthesis Of Artificial Chitin and Derivmentioning

confidence: 99%

“…Extension of the chemoenzymatic method to the synthesis of homogeneous glycoforms of ribonuclease B carrying full-size natural N-glycans was achieved (Scheme 9). 60,171 The Endo-M N175A mutant could take both high-mannose-type and complex-type N-glycan oxazolines as substrate for transglycosylation, while the Endo-A N171A mutant is specific only for transferring high-mannose-type N-glycans. Further systematic site-directed mutagenesis at the N175 of Endo-M revealed that the Endo-M N175Q mutant showed remarkable enhanced transglycosylation efficiency over other mutants.…”

Section: Generation Of Engase-based Glycosynthases For Transglycosylamentioning

confidence: 99%

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Endoglycosidases for the Synthesis of Polysaccharides and Glycoconjugates

Wang

2016

Advances in Carbohydrate Chemistry and Biochemistry

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Recent advances in glycobiology have implicated essential roles of oligosaccharides and glycoconjugates in many important biological recognition processes, including intracellular signaling, cell adhesion, cell differentiation, cancer progression, host-pathogen interactions, and immune responses. A detailed understanding of the biological functions, as well as the development of carbohydrate-based therapeutics, often requires structurally well-defined oligosaccharides and glycoconjugates, which are usually difficult to isolate in pure form from natural sources. To meet with this urgent need, chemical and chemoenzymatic synthesis has become increasingly important as the major means to provide homogeneous compounds for functional glycocomics studies and for drug/vaccine development. Chemoenzymatic synthesis, an approach that combines chemical synthesis and enzymatic manipulations, is often the method of choice for constructing complex oligosaccharides and glycoconjugates that are otherwise difficult to achieve by purely chemical synthesis. Among these, endoglycosidases, a class of glycosidases that hydrolyze internal glycosidic bonds in glycoconjugates and polysaccharides, are emerging as a very attractive class of enzymes for synthetic purposes, due to their transglycosylation activity and their capability of transferring oligosaccharide units en bloc in a single step, in contrast to the limitation of monosaccharide transfers by common glycosyltransferases. In this chapter, we provide an overview on the application of endoglycosidases for the synthesis of complex carbohydrates, including oligosaccharides, polysaccharides, glycoproteins, glycolipids, proteoglycans, and other biologically relevant polysaccharides. The scope, limitation, and future directions of endoglycosidase-catalyzed synthesis are discussed.

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Section: Generation Of Engase-based Glycosynthases For Transglycosylamentioning

confidence: 99%

Section: Enzymes As a Tool For The Synthesis Of Glycans And Glycoconjmentioning

confidence: 99%

Section: Chitinase-catalyzed Synthesis Of Artificial Chitin and Derivmentioning

confidence: 99%

Section: Generation Of Engase-based Glycosynthases For Transglycosylamentioning

confidence: 99%

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Endoglycosidases for the Synthesis of Polysaccharides and Glycoconjugates

Wang

2016

Advances in Carbohydrate Chemistry and Biochemistry

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“…In single top quark production, the produced top is highly polarised allowing for a direct test of the V − A structure of weak interaction [11]. Finally, single top production is one of the interesting channels to look for new physics beyond the Standard Model [12][13][14][15]. Extensive studies of single top production at hadron colliders including radiative corrections have been performed at NLO [16][17][18][19][20][21][22][23][24] and NNLO [25][26][27] in the strong coupling.…”

Section: Introductionmentioning

confidence: 99%

Probing anomalous Wtb couplings at the LHC in single t -channel top quark production

Jueid

2018

Phys. Rev. D

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We study the sensitivity of certain observables to the anomalous right tensorial coupling in single top production at the LHC at √ s = 13 TeV. The observables consist of asymmetries constructed from the energy and angles of the decay products of the top quark produced in single top production through t-channel. The computation is done at Leading Order (LO) and Next-to-Leading Order (NLO) in the strong coupling in the 5 flavor scheme. We have estimated projected limits on the anomalous coupling, both at the parton level without cuts and at the particle level with cuts. We find that the asymmetries are robust with respect to the higher order QCD corrections and are indeed a very good probe of this anomalous coupling of the top. Hence they can be be used as experimental probes of the same.

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Pair Production of Heavy Charged Gauge Bosons in pp Collisions at LHC

et al. 2023

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Two oppositely charged new heavy gauge boson pair production at the Large Hadron Collider (LHC), is presented in this paper. These bosons are known as $W^{'}$ boson due to the reason that it is the heavy version of Standard Model's weak force carrier, the $W$ boson. The production cross section and decay width in proton-proton ($pp$) collision at \sqrts~= 8 TeV are calculated for different masses and coupling strengths of $W^{'}$. Efficiencies for different signal regions and branching ratios for different decay channels are computed. In this study, the pair production ($W^{'^{+}}W^{'^{-}}$) is considered in emerging new physics as a result of $pp$ collision at \sqrts~= 8 TeV at the LHC with final state containing two tau ($\tau$) leptons and two neutrinos (each $W^{'}$ decay to $\tau$ and its neutrino). The event selection efficiency similar to the CMS experiment is used for the mass of $W^{'}$ to set lower limits for different coupling strengths of $W^{'}$ and, the obtained results are presented in this work. \textcolor{blue}{For heavy gauge bosons, when coupling strength is similar to that of Standard Model's $W$ boson, the mass of $W^{'}$ below 445 GeV are excluded at a confidence level of $95\%$.

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Search for W′ signal in single top quark production at the LHC

Cited by 6 publications

References 42 publications

Endoglycosidases for the Synthesis of Polysaccharides and Glycoconjugates

Endoglycosidases for the Synthesis of Polysaccharides and Glycoconjugates

Probing anomalous Wtb couplings at the LHC in single t -channel top quark production

Pair Production of Heavy Charged Gauge Bosons in pp Collisions at LHC

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