Search for Urogenital Tract Infections in Patients with Symptoms of Prostatitis: Studies on Aerobic and Strictly Anaerobic Bacteria, Mycoplasmas, Fungi, Trichomonads and Viruses

Abstract

Seventy-nine patients with symptoms of nonacute prostatitis and 20 healthy volunteers were examined for uro-genital tract infection with bacteria, mycoplasmas, fungi, trichomonads and viruses. No differences in the results of the bacterial cultures were found between the patients and the controls. In only a few cases were established urinary tract pathogens found, but in no instance were these findings reproducible in later specimens. The cultures of the expressed prostatic fluids and the samples of semen gave no information of the occurrence of bacteria over and above that obtainable from examination of the urethral specimens. Significant bacteriuria was not found in any of the patients. Though Neisseria gonorrhoeae could not be isolated from any of the subjects, immunofluorescent studies revealed such organisms in seminal fluid in 8% of the patients. Nine of the patients had 1 to 3 years been considered successfully treated for gonorrhoea. Five of these nine patients were still found to harbour gonococci, as judged from the immunofluorescent studies. Corynebacterium vaginale was recovered in an equally low frequency (5%) from the patients and the volunteers. There was no significant difference in the incidence of T-mycoplasmas between the patients (46%) and the controls (35%), while Mycoplasma hominis was only found in the patients (10%). Trichomonas vaginalis could not be detected in wet smears of expressed prostatic fluid in any of the subjects, but could be cultured from one such specimen. Metacycline treatment (performed according the double blind cross-over technique) was studied for effects on the bacterial flora. In about 10% of the patients, an earlier not observed relative dominance of gram-negative rods was found on the cultures made after the therapy. Candida albicans was only isolated from the patients. It was found more often after (24%) than before the (15%) treatment. Complement-fixing antibodies to N. gonorrhoeae, cytomegalovirus and Chlamydia were found in 10, 19, and 33% of the patients, respectively. The corresponding figures for the healthy males were 0, 20 and 5%.

Current Therapeutics, Their Problems, and Sulfur-Containing-Amino-Acid Metabolism as a Novel Target against Infections by “Amitochondriate” Protozoan Parasites

“…In symptomatic men, common complaints include scanty clear to mucopurulent discharge, dysuria, and mild pruritus or a burning sensation immediately after sexual intercourse (166). Complications associated with trichomoniasis include nongonococcal urethritis, prostatitis, balanoposthitis, urethral disease, and infertility (131,167,197). Pneumonia, bronchitis, and oral infection caused by T. vaginalis have also been documented (132).…”

Treatment of Infections Caused by Metronidazole-ResistantTrichomonas vaginalis

“…Symptomatic men present with a clear or mucopurulent discharge and dysuria (57,58). Complications associated with T. vaginalis infection include prostatitis, balanoposthitis, epididymitis, and infertility (56,82).…”

Chlamydial Infection in Urologic Diseases

“…Although Mardh and Colleen (Mardh et al, 1972) suggested that C. trachomatis may be implicated in as many as one third of men with CP, their follow-up studies employing culturing and serologic tests could not confirm C. trachomatis as an etiologic agent in idiopathic prostatitis (Mardh & Colleen, 1975;Mardh et al, 1978). Shortliffe and Wehner (Shortliffe & Wehner, 1986) came to a similar conclusion when they evaluated antichlamydial antibody titers in prostatic fluid.…”